Liver
stub — Seeded as a structural anchor for the digestive-system; not yet written out.
The liver is the central metabolic organ — glucose/lipid homeostasis, xenobiotic clearance, coagulation-factor and vitamin-K-dependent-protein synthesis (vitamin-k-cycle runs prominently here), and acute-phase/inflammatory signaling. Liver aging features hepatocyte polyploidy and senescence, declining regenerative capacity, altered SREBP2/cholesterol metabolism, and steatosis. A primate single-nucleus liver-aging study is already ingested: yang-2023-primate-liver-aging-snrna-srebp2.