Planned coverage
Proactive coverage intent — topics the wiki intends to cover that the reactive discovery mechanisms don’t surface on their own. This page replaces the former ROADMAP.md (retired 2026-06-02; see schema-history R50), which had decayed into ~80% closed-campaign archive (now living only in log/) plus a forward-queue that duplicated what the lint mechanisms already track.
How seeding priority actually works now
Three mechanisms drive what gets seeded; this page is only for the gap none of them catches:
- Priority ranking → inbound-count discovery (lint-pass § Step 3). For any “what should we seed next?” question, rank referenced-but-unseeded entities by distinct inbound
[[link]]count. This is canonical — static checklists decay (the R27 “UPR listed as 5, actually 23” lesson). - Reactive discovery → ad-hoc + distributed
#stub. New studies and user questions surface pages as they arise; and pages mark their own missing neighbours inline with#stub/ implicit-stub wikilinks (e.g. the organ-system MOCs each list their planned pages). The missing-page lint aggregates these — it is the de-facto distributed roadmap, living where it’s relevant. - Proactive intent → this page. Topics that nothing links to yet (zero inbound signal) so (1) can’t rank them and (2) won’t surface them, but that we know belong in the wiki. Keep this list short and curated; when an item acquires inbound links, it graduates to the inbound-count queue and should be removed here.
Proactive coverage intent (low/zero inbound signal)
Telomere maintenance machinery
[[telomere]]— telomere DNA structure / T-loop biology / measurement methods (distinct from telomere-attrition hallmark and the telomerase machinery)[[tcab1]]/[[wrap53]]— Cajal-body targeting subunit of telomerase[[topoisomerase]]— DNA topology (also a fisetin off-target)
Endocrine / signaling protein clusters (skin + neuro + metabolic)
- Melanocortin completion: PCSK1, PCSK2, CPE, PAM (POMC processing); AGRP, ASIP, MC2R
- Neurotrophin signaling: NGF, NTRK1/2/3, NGFR
- cAMP signaling: ADCY family, PRKACA, RAPGEF3, GNAS, CREB1, CRTC1, PDE4
- Specialized pro-resolving mediators (SPM): GPR32, ChemR23, LGR6, ALOX15, ALOX5, ALOX12, PTGS2
- Melanogenesis enzymes: MITF, TYR, TYRP1, DCT
Pathways
- HGF-MET signaling · HPA axis · NO-cGMP-PKG · GH-JAK-STAT · arachidonic-acid pathway · omega-3 metabolism · phospholipase-A2
Proteostasis cluster (surfaced at R27/R28 close)
- HSP90 paralogs: HSP90AB1 (constitutive cytosolic), GRP94/HSP90B1 (ER), TRAP1 (mitochondrial)
- UPR effectors: IRE1α/ERN1, XBP1, GRP78/HSPA5, CHOP/DDIT3 — plus an IRE1α cell-nonautonomous-longevity hypothesis-page candidate (Taylor/Dillin 2013;
treatment-mode: conceptual-frame) - TAK1-binding cluster: TAB1, TAB2, TAB3; IRAK1/IRAK2 (lower priority — IRAK4 is the master kinase)
Phenotypes / processes
- Laron syndrome (referenced from GHR)
Tyshkovskiy 2026 long-tail (seed only if inbound count rises)
- Universal-clock genes each with one-sentence support in the paper:
Ddost,Gpx1,Nmrk1,Fmo3,Vcam1 - Predecessor transcriptomic clocks as biomarker pages if needed: Peters 2015 blood clock, RNAAgeCalc, Buckley 2023 brain clock (noted as
#gapon transcriptomic-clock-tage)
Deferred propagation backlog
Targeted corrections deferred from prior verifier sweeps; not blocking new seeding. Each is a single edit, best done when the related cluster is next touched.
- metformin — Martin-Montalvo χ² values; Cabreiro 2013 dose-specific numbers + live-bacteria requirement
- rapamycin — Mannick 2018/2021 trial-identity disambiguation
- stem-cell-exhaustion MOC — Sim 2002 demyelination model fix; MSC therapy CRATUS quantitatives
- chronic-inflammation MOC — Carroll 2015 directionality; BHB-NLRP3 K⁺-efflux mechanism
- notch-pathway — verify Kalamakis 2019 attribution if cited