aging_wiki — chronological log

Thin chronological index. Full entry content lives in log/ sub-files; this file holds pointers only.

2026-08-13 ingest+correction — fermented foods (including kimchi) and resistant starch evidence cluster; corrected potato-RS2 taxa/tolerability and removed the universal fiber-gas adaptation claim → 2026-08-13

Sub-file structure:

log/R<N>.md — numbered campaign-round entries (round-close summary + verifier + propagation entries for that round)
log/YYYY-MM-DD.md — ad-hoc daily entries (one-off user-requested ingests/verifies not part of a numbered round)
log/lint.md — periodic lint-pass entries (## [date] lint)
log/recency.md — recency-refresh sweeps (R34 backfill batches and similar)

Entries below are in reverse-chronological order (newest first). Each line: date, summary, link to sub-file.

2026-08-09 ingest+verify | Wu 2026 ovarian IL-11/matrix stiffness + Widjaja 2024 systemic IL-11 healthspan/lifespan + Li 2025 ribosome dysregulation/IVF sirolimus; 6 verified studies, 13 independently verified supporting atomic pages and 12 propagated pages; retained nonsignificant recalculated Wu pregnancy contrasts, incomplete/censored Widjaja survival, and null mature-oocyte/incomplete live-birth Li boundaries → 2026-08-09
2026-07-30 ingest+verify — Aitken 2026 genetic background and experimental cancer evolution (user-requested). Added verified aitken-2026-genetic-background-cancer-evolution after full article, Extended Data, reporting-summary and supplement review. The 581 main-analysis lesions were dysplastic nodules, not HCCs; the strain-specific “latency” measure was a fixed collection endpoint; whole-genome duplication was inferred. Propagated the mutation-burden/selection distinction and background-specific RAS–MAPK routes to hepatocellular-carcinoma, somatic-mutation-accumulation, ras-mapk and mus-musculus, with no direct normal-aging or human-ancestry claim. → 2026-07-30
2026-07-15 lint — relative wikilink portability sweep: converted 259 ../-prefixed wikilinks across 35 public files to base-aware canonical links; resolved stale JAK-STAT and intervention-modality targets; preserved 16 intentional missing-page stubs. → log/lint > 2026-07-15 lint — relative wikilink portability sweep
2026-07-15 ingest+verify — vegetarian diet and all-cause mortality evidence review (user-requested). Added scoped-verified vegetarian-diet after a wiki-first search, independent RCT/cohort reviews, and a primary-source verifier pass. No mortality-powered RCT comparing an optimized vegetarian/vegan diet with an otherwise equivalent meat-inclusive diet was found; direct trials remain surrogate-only. Corrected NEW Soul, CARDIVEG, and EPIC-Oxford descriptions; added the 2026 substitution meta-analysis; propagated the Cochrane PMID correction to dietary-fat-quality. → 2026-07-15
2026-07-14 ingest+verify — CMLase/CrGO-897 engineered protein-bound CML repair (user-requested). Added verified trabosh-2026-cmlase-deglycation and verified cmlase, plus the age-adduct-deglycation mechanism class. Full paper/source-data audit confirms direct CML-to-lysine repair but not AGE-crosslink cleavage: CML is monovalent, glucosepane/pentosidine were not tested, and all human results were ex vivo with one older donor per headline tissue. Corrected the aortic source-data estimate (~66% vs inactive, despite paper text >70%) and downgraded Delanghe-2024 FAOD evidence to free amino-acid/sugar-mixture ion disappearance. → 2026-07-14
2026-07-11 ingest+verify — glymphatic-system process + foundational evidence refresh (user-requested). Added verified glymphatic-system, xie-2013-sleep-glymphatic-clearance, and kress-2014-glymphatic-aging. Integrated Smith–Mestre AQP4 disagreement, Miao 2024/correction + 2025 dispute, Hauglund 2025 norepinephrine/vasomotion work, and 2026 human hydrodynamic/proxy evidence. Propagated endpoint-specific wording to sleep, brain, astrocytes, neurons, nervous-system, and dti-alps; removed the stale Xie full-text gap and the claim that sleep is a validated glymphatic therapy. → 2026-07-11
2026-07-11 ingest+verify — Thapaliya 2026 ME/CFS DTI-ALPS study + method audit (user-requested). Added verified thapaliya-2026-me-cfs-dti-alps (n=58) and verified dti-alps. Propagated the lower bilateral-index association and its symptom/null pattern to sleep and brain, while preserving the construct-validity limit: Mossige 2026 found limited correspondence with contrast-MRI clearance. Flagged malformed Table 3 SD/effect-size/CI entries rather than inferring repairs. → 2026-07-11
2026-07-11 ingest — L-theanine cognition/affect meta-analysis (user-prompted). Added l-theanine compound page + gerolymos-2026-l-theanine-meta-analysis (31 placebo-controlled oral RCTs, n=1,168). Acute choice reaction time was the clearest signal; stress was bias-sensitive, fatigue null, anxiety mostly null, and depression sensitivity-only. No aging hallmark claim assigned. Both pages remain verified:false because the full subscription article was unavailable; publisher abstract/figures/supplement checked. → 2026-07-11
2026-06-09 ingest — EU/global UV-filter cluster (seed+verify, applying R52). 6 new type: compound pages for the EU-approved-not-FDA sunscreen filters that were previously only umbrella-discussed: bemotrizinol (Tinosorb S), bisoctrizole (Tinosorb M), drometrizole-trisiloxane (Mexoryl XL), iscotrizinol, tinosorb-a2b, and ecamsule (Mexoryl SX — the lone fda-approved via product-specific NDA021502, not OTC-monograph). All verified:true (IDs via PubChem/ChEMBL/OpenFDA). Verifier caught a fabricated author list (D’Ruiz 2023), a non-existent NDA (“22-015”), six bad citations on drometrizole, a wrong SCCS guess (=Acid Orange 7), and confirmed Tinosorb A2B ≠ TriAsorB. Propagated: triasorb/mexoryl-400 clinical-stage → approved-ex-us; wired links + ecamsule wording fix into uv-protection; de-staled retinoids forward-refs; acronyms. Flagged a Matta-2019 Cmax discrepancy on the verified uv-protection page for a dedicated pass. → 2026-06-09
2026-06-09 schema — R52: clinical-stage: approved-ex-us added to the type: compound enum (+ intervention class pages) for agents approved by a stringent non-US regulator (EMA/MFDS/PMDA/MHRA) but not FDA — not a weaker signal than FDA approval, often US regulatory lag (sunscreen-monograph backlog). Applied to pdrn; motivates the UV-filter cluster above. → 2026-06-09
2026-06-09 ingest — injectable skin boosters (full build-out) from a retracted-paper lead (Yi et al. 2024, Skin Res Technol, DOI 10.1111/srt.13627 — not cited; retracted by Wiley), rebuilt on the clean independent replacement Rho et al. 2024 (Arch Plast Surg, DOI 10.1055/a-2366-3436, OA). 5 new pages — umbrella injectable-skin-boosters, pdrn/polynucleotides (A2A-agonist salmon-DNA), biostimulatory-fillers (PLLA/PCL/PDO/PDLLA/CaHA), exosome-skin-therapy, the anchor study + an adora2a stub — all seeded→verified→verified:true. Verifier caught the seeder importing n=72 from the retracted Pak 2014 into the Lee 2020 RCT (actually n=27, null on primary endpoints), an overstated Porcello collagen claim, a PDO claim mis-blamed on retracted Zhou 2023 (→ Kim CM 2019), and that Jafarzadeh’s “exosome” review is 79% conditioned-media. Reconciled a parallel-seeder duplicate-class race in intervention-classes.md (canonical adenosine-A2A-receptor-agonism; new dermal-biostimulation + paracrine-cargo-delivery). → 2026-06-09
2026-06-08 ingest — VERVE-102 in-vivo PCSK9 base editing, Phase 1 (Vafai 2026, NEJM; user-prompted, method-ramifications-weighted). Seeded studies/vafai-2026-verve-102-pcsk9.md (n=35; single-dose ABE8.8/GalNAc-LNP; PCSK9 −88% / LDL-C −62% at 1.0 mg/kg, durable ≥12 mo, no DLT) + first-class method page methods/in-vivo-base-editing.md (ABE/CBE chemistry, LNP-GalNAc delivery, off-target landscape, durability/evidence-weight). Both verified:false, verifier queued. Propagated to crispr-base-editing-pcsk9 (filled its flagged “no full Phase 1 paper” gap; corrected Cas12→Cas9-nickase ABE8.8 per primary source) + pcsk9. → 2026-06-08
2026-06-03 ingest+verify — sex-differential aging campaign, batches 7-9 + campaign close (female conditions + reproductive organs/cells + mechanisms; user-requested; all seeded + verified → verified:true). 13 pages: PCOS, endometriosis, POI, Turner; uterus, breast, prostate, sertoli/spermatogonial/theca cells; iron (first type:metabolite), ferroptosis, XIST. (mtDNA page reconciled away — existing mtdna.md reused via alias.) Verifier caught 4 inverted findings (Pedroso telomere, Forslund menopause-timing, Barnard superficial-peritoneal, Nie SSC framing), a wrong-cohort error (Figueroa), a cell-type misattribution (Paul-Robaire), + several bad DOIs/fabricated stats. Fixed a 404 DOI on the verified XCI page. MOCs updated. CAMPAIGN COMPLETE: 39 atomic pages + 5 patches + 1 capstone MOC, all verified. → 2026-06-03
2026-06-03 ingest+verify — sex-differential aging campaign, batch 6 (hormone-replacement interventions; user-requested; seeded + verified → all verified:true). 4 class pages: hormone-replacement-therapy, testosterone-replacement-therapy, aromatase-inhibitors, selective-estrogen-receptor-modulators. Neutral evidence synthesis (user’s pro-aging prior held at arm’s length): none is a validated geroprotector; AIs clearest pro-aging case (estrogen deprivation) but cancer-justified; MHT/TRT timing/indication-dependent ~neutral mortality. Verifier caught a 9-fold dose error (ELITE), a wrong primary endpoint (Bhasin 2026), a misresolved DOI (bhatnagar), multiple HR errors. New mechanism classes: aromatase-inhibition, SERM. → 2026-06-03
2026-06-03 ingest+verify — sex-differential aging campaign, batch 5 + capstone (phase-1 final). Patched 5 existing verified disease pages with sourced+verified ## Sex differences sections (alzheimers ⅔-female/APOE×sex, cardiovascular post-menopausal convergence, skin estrogen-collagen, frailty health-survival paradox, immunosenescence female-immunity/autoimmunity). Built capstone MOC frameworks/sex-differences-in-aging.md (registered in index + README). Campaign complete: 24 atomic pages + 5 patches + 1 MOC, all verified. Verifier caught a fabricated method+n on the immunosenescence patch (Márquez 2020). → 2026-06-03
2026-06-03 ingest+verify — sex-differential aging campaign, batch 4 (distinctively-sexed mechanisms; seeded + wave-D verified → all verified:true). 4 pages: x-chromosome-inactivation (XCI erosion + Dou-2024 XIST-autoimmunity), female-longevity-advantage (evidence-aggregating MOC: Zarulli/Lemaître phenomenon + 8 candidate mechanisms), mothers-curse (mitochondrial male-load, contested), reproductive-aging-tradeoffs (Poganik-2023 pregnancy-clock + parity). Corrections: Trinidad-slavery date, Ryan-2018 clock misattribution, Poganik cohort-n. 23 campaign pages now all verified. → 2026-06-03
2026-06-03 verify — sex-differential aging campaign, batch 3 (wave C; all 7 male-axis + symptom pages → verified:true). Every page corrected: TRAVERSE MACE HR wrong direction (testosterone), confabulated Zhang-2024 mechanism (lh), reversed elinzanetant hepatotoxicity claim (vasomotor-symptoms), badly wrong REVIVE figures (GSM), Kong SSC-division misattribution (testis), EMAS prevalence (andropause). No leaked errors elsewhere; menopause cross-refs de-staled. → 2026-06-03
2026-06-03 ingest — sex-differential aging campaign, batch 3 (male foundation + female menopausal symptoms; user-prompted). Seeded 7 pages (verified:false, queued): testosterone, andropause, testis, leydig-cells, lh, vasomotor-symptoms, genitourinary-syndrome-menopause. Male axis deliberately contrasted with abrupt female axis; paternal-age effect, KNDy/NK3R VMS mechanism, GSM chronic-vs-remitting. Added androgen-receptor-agonist mechanism class. MOC reorganized into female/male/shared axes. → 2026-06-03
2026-06-03 verify — sex-differential aging campaign, batches 1+2 (all 12 foundation pages → verified:true; user chose to verify before continuing). 12 wiki-verifier passes vs primary PDFs; every page needed corrections (high seeder-error rate). Highlights: ovary follicle-count table fully wrong (7M-germ-cell vs NGF conflation, fixed to Wallace-Kelsey); a 2nd wrong DOI (amh/durlinger); Wright-2014 fabricated CI; Melville-2025 sign inversion; Shang-2024 omitted null; FSH FSHβ+/− genotype crux error; Wilson-2019 HR misrepresentation; Brincat collagen figure fabricated. No leaked values elsewhere (grep clean). → 2026-06-03
2026-06-03 ingest — sex-differential aging campaign, batch 2 (estrogen signaling + reproductive endocrine proteins; user-prompted). Seeded 6 type: protein pages (all verified:false, queued): esr1 (ERα), esr2 (ERβ), gper, cyp19a1 (aromatase), amh, fsh. Resolves the estrogen-receptor stubs dangling off batch-1 estradiol. Propagated to reproductive-system MOC; fixed a seeder-introduced wrong DOI on batch-1 ovary.md (dewailly2014 dmu002→dmt062). → 2026-06-03
2026-06-03 ingest — sex-differential aging campaign, batch 1 (female reproductive foundation; user-prompted). Seeded 6 atomic pages (all verified:false, queued): tissues/ovary.md, phenotypes/menopause.md, molecules/compounds/estradiol.md, molecules/compounds/progesterone.md, cell-types/oocytes.md, cell-types/granulosa-cells.md. Propagated to reproductive-system MOC, resolved the sex-hormone #gap/unsourced on altered-intercellular-communication, reciprocal links on osteoporosis/brca1; added progesterone-receptor-agonist mechanism class. Audit correction: esr1/esr2/gper/cyp19a1 do NOT exist (initial audit was wrong) — folded into next wave. → 2026-06-03
2026-06-03 update — interventions/lifestyle/exercise.md (ad-hoc): added “Training frequency and body recomposition” section answering a recurring practical question (daily vs. alternating/recovery-day training × recomposition rate). Synthesizes STRRIDE-AT/RT (Willis 2012; fat-loss vs lean-gain decoupling), Schoenfeld 2016 (volume-equated frequency null), Wilson 2012 (concurrent-training interference scales with endurance frequency; running>cycling), + concurrent2025 / ACSM 2026. 5 citations DOI/PMID-sanity-verified; page stays verified:true with dated scope addendum (new effect sizes directional, not PDF-checked). Surfaced gap/dose-response-unclear (no volume-matched daily-vs-alternating recomposition RCT). → 2026-06-03
2026-06-02 schema — R51: relocated the 6 type: experiment pages + README from public top-level experiments/ into the PRIVATE protocols/experiments/ tree (user judged them working drafts akin to brainstorming). Experiment↔causal-graph integration is now one-way; de-linked 4 public inbound refs (causal-graph-data, index, chronic-venous-disease) keeping the prose as plain literature-gap statements. Leak-gate + invariant extended to catch the bare experiments/-prefixed wikilink alias. → 2026-06-02
2026-06-02 ingest — interventions/dietary/multivitamins.md (ad-hoc): seeded the multivitamin-mineral intervention page (mode: dietary, human-evidence-level: limited-negative). Synthesizes Loftfield 2024 (mortality null, n=390k), COSMOS (cancer/CVD null) + COSMOS cognition exception, PHS-II (modest cancer), USPSTF 2022 (against beta-carotene/vitamin E), HOPE-2 (homocysteine-lowering null). Framing: deficiency-insurance not geroprotector; formulation (iron/beta-carotene/high-E) is the harm subset. verified:false + banner, queued for verifier. → 2026-06-02
2026-06-02 repo-hygiene — retired ROADMAP.md (R50; decayed to mostly closed-campaign archive + a forward queue superseded by inbound-count discovery + ad-hoc + distributed #stub markers); folded residual proactive intent + propagation backlog into planned-coverage; repointed wiki-seeder/lint-pass/index/gaps refs. Also surfaced four AI-extraction failure-mode conventions from private memory into verifying-extraction. → 2026-06-02
2026-06-02 build — organ-system MOC framework (user-requested): new type: organ-system schema (R49); 11 body-system MOCs in organ-systems/ (cardiovascular/musculoskeletal/integumentary/nervous/hematopoietic/immune/endocrine/digestive/urinary/respiratory/reproductive) resolving the previously-broken parent-system: links; by-organ-system index; 6 organ stubs (kidney/liver/lung/pancreas/thymus/spleen); seeded+verified thyroid, parathyroid, vitamin-k-cycle. Verifiers caught an inverted PTH-paradox mechanism + a UBIAD1 expression error; scrubbed a leaked local filesystem path from a verifier log note. → 2026-06-02
2026-06-02 verify — tissues/parathyroid.md → verified:true (partial scope). 6 corrections: Farrell 2018 redesignated as single-institution retrospective (n=33,652), not a 17-study meta-analysis; 63% PTH increase figure added; Jilka 2007 PTH-paradox table corrected (continuous-PTH mechanism: Runx2 suppression, not cAMP-PKA promotion; intermittent-PTH anti-apoptotic: cAMP→PKA→Bad/Bcl-2, not PTHrP/PP2A); Minisola 2022 prevalence figures made precise (233/100,000 women, 85/100,000 men); 85–90% single-adenoma claim tagged gap/unsourced. Supersession check run — no superseding evidence found; post-2021 PTH reference interval literature consistent with existing framing. → 2026-06-02
2026-06-02 verify — tissues/thyroid.md → verified:true (partial scope). 5 corrections: nodule malignancy rate in body 4–5% → 23.6% (Lin 2005 surgical-series denominator clarified; 3.9% all-evaluated figure added); TRUST trial description expanded with TSH inclusion range, exact p-values + 95% CIs, ThyPRO instrument name, MCID, randomization numbers, dose details; TRUST footnote expanded with mean age, sex, median follow-up, SD on TSH outcomes; Lin 2005 footnote surgical denominator made explicit; gap entry corrected “only one year” to “primary endpoint at one year (median 17.3 months)”. TRUST full PDF read; 4 other sources abstract-only (closed-access). → 2026-06-02
2026-06-02 verify — pathways/vitamin-k-cycle.md → verified:true. 1 correction: UBIAD1 tissue-expression “brain, testis, arterial wall” → “brain, testis, pancreas”; mRNA-vs-protein paradox in heart noted. Nakagawa 2010 PDF read; Reactome R-HSA-6806664/R-HSA-6806674 confirmed. Stale “vitamin-k-cycle is a stub” note removed from ggcx.md. → 2026-06-02
2026-06-02 ingest+verify — vitamin-K-cycle enzymes (user “continue”; final lint-sweep tier): seeded + same-day-verified molecules/proteins/ggcx.md (γ-glutamyl carboxylase, tier 4) and molecules/proteins/vkorc1.md (vitamin K epoxide reductase, tier 3 + documented warfarin paradox; vkor aliased). Verifiers caught an unsourced PDB ID, a wrong SNP (rs2884737→rs8050894), and several count/topology errors — all corrected, none propagated. Cleared the ggcx/vkor gap markers on matrix-gla-protein + vitamin-k; reciprocal stubs resolved. Bone/vascular cluster now fully seeded + verified. → 2026-06-02
2026-06-02 ingest+verify — gap-fill batch (user-prompted, continuing the lint-sweep ranking): seeded + same-day-verified studies/mcclung-2019-loft.md (LOFT odanacatib RCT), phenotypes/hyperphosphatemia.md, molecules/compounds/vitamin-k.md, processes/splicing-dysregulation.md. Schema fix: phenotype was missing from CLAUDE.md’s verified-discipline type list + frontmatter block (27/28 phenotype pages already carry it) — added. Verifiers caught a Diederichsen-2022 sign error, a fabricated compound (“H3BS-10000”), and a fabricated Block-2004 RR — all corrected, none propagated. Cleared vitamin-k/splicing-dysregulation gap markers on matrix-gla-protein + sf3b1. → 2026-06-02
2026-06-02 verify — processes/splicing-dysregulation.md → verified:true (partial scope: Scaffidi 2006 + Holly 2013 via PMC full text; Latorre 2017 + Pabis 2024 full PDFs; Hayman 2026 abstract-only; 9 sources not re-read). 8 corrections: “one-third” → 38% InCHIANTI (27/71); fabricated compound “H3BS-10000” removed; quercetin/fisetin misattribution removed; hnRNPB1 replaced with actual 20-factor panel; mouse IR/readthrough over-claim corrected (Pabis 2024 mouse effects non-significant); Scaffidi 2006 quantitative data added; two incorrect gap/no-fulltext-access tags removed. No supersession found. → 2026-06-02
2026-06-02 verify — molecules/compounds/vitamin-k.md → verified:true (partial scope: 4 full PDFs + Knapen abstract; 11 corrections including Diederichsen 2022 sign error +17→−17 AU and 720 µg dose omission; clinical-trials-active=7 methodology documented; supersession check run — Hasific 2025 AVADEC sub-study consistent with framing, no supersession). → 2026-06-02
2026-06-02 verify — phenotypes/hyperphosphatemia.md → verified:true (partial: Block 2004 and Kuro-o 2010 abstract-only; Isakova 2011 PMC-abstract-only; Kuro-o 2021 + McGovern 2013 + Larsson 2010 full PDFs). 5 corrections: fabricated Block 2004 single-RR removed; “patient-years” → “patients”; McGovern comparator band 0.87–1.13 → 0.75–1.00 mmol/L; Larsson non-CV-mortality Pi claim corrected; Isakova stage annotation tightened. → 2026-06-02
2026-06-02 ingest — phenotypes/hyperphosphatemia.md seeded (ad-hoc, user-prompted); ICD-10-CM E83.39 confirmed; framed as causal-graph node (FGF23–Klotho–phosphate axis → vascular-calcification); 6 DOIs confirmed; ICD-11 pending (auth required). → 2026-06-02
2026-06-02 ingest — bone-cluster seeding (user-prompted, follow-on to the gap sweep): seeded cell-types/osteoblasts.md (CL:0000062), cell-types/osteoclasts.md (CL:0000092), molecules/compounds/romosozumab.md (anti-sclerostin mAb) — all verified same day (see verify pointers below). bmsc resolved by aliasing to mesenchymal-stem-cells (already the canonical BM-MSC home) rather than a duplicate page; [[bmsc]] links repointed; osteoblast/osteoclast/bmsc #gap/needs-page markers cleared across 7 pages. Propagation: confirmed Farr-2016 SASP misattribution was confined to osteoblasts (no other page cites it); fixed a stale wrong Zheng-2023 DOI (42592→42538, confirmed via PubMed/Crossref) + FRAME T-score footnote on already-verified sost. → 2026-06-02
2026-06-02 verify — cell-types/osteoclasts.md → verified:true (partial: Miyamoto/Drake/Kuno abstract-only; Yang/Rogers unavailable). Fabricated odanacatib stroke risk corrected (23%→32%, HR 1.32 95% CI 1.02–1.70, from primary LOFT report McClung 2019, n=16,071); AF-mechanism attribution removed (AF not elevated in LOFT); DC-STAMP KO severity softened; resorption-pit pH qualified; Luo 2025 first-author fixed. CL:0000092 confirmed. → 2026-06-02
2026-06-02 verify — cell-types/osteoblasts.md → verified:true. Critical SASP attribution corrected: Farr 2016 shows osteocytes and myeloid cells are the dominant SASP source in bone (not osteoblasts); n corrected (12/10 per group, not 5–10); MACS not FACS; Kusumbe 2014 pharmacological agent corrected (DFM not PDGF-BB/Notch); Xu 2018 organism corrected (rat not mouse). Seeman 2003 closed-access; Manolagas 2010 abstract-only. Downstream: osteocytes.md, cellular-senescence.md, senolytics.md → 2026-06-02
2026-06-02 verify — molecules/compounds/romosozumab.md → verified:true (partial: BRIDGE closed-access; LIDA/Chen/Zheng/Ferrer/Bandeira/Liu/Cipolloni/Handel abstract-only). FRAME + ARCH PDFs read end-to-end. 5 corrections: FRAME T-score criterion (lumbar spine→total hip or femoral neck); Chen 2026 meta DOI (1526408→1732708, non-existent DOI); Zheng 2023 MR DOI (42592→42538); clinical-trials-active (10→16); ARCH table expanded with exact CV sub-event counts and hip fracture endpoint. DrugBank gap/needs-canonical-id retained (blocked by Cloudflare). No supersession found (Chen 2026 meta-analysis consistent with existing framing). Downstream propagation needed: sost.md FRAME T-score description; osteocytes.md FRAME cross-reference → 2026-06-02
2026-06-02 lint — stale page-existence gap sweep (user-prompted). Cross-checked the full #gap/needs-page/needs-stub/needs-*-page/needs-seeding/missing-page family against the live file inventory; removed/rewrote stale markers whose target now exists across 20 pages (il-6, tocilizumab, ewingella, bacterial-cancer-therapy, peptide-therapeutics, retinoids, pcsk9, ITP, bone, osteocytes, osteoporosis, runx2, bmp-2, osteopontin, mgp, sost, dkk1, wnt-beta-catenin, arteries, endothelial-cells, phosphate-additive-reduction, ketogenic-diet). Ranked the remaining real gaps by inbound demand (osteoblasts=9 top) → log/lint > 2026-06-02 lint — stale page-existence gap sweep
2026-06-02 ingest+verify — seeded interventions/procedural/microneedling.md (ad-hoc, user-prompted; granular split-out from dermatologic-resurfacing, deferred at R44). mode: procedural; neutral evidence appraisal foregrounding the mechanism-vs-efficacy distinction — mechanism real (El-Domyati 2015 histology, n=10 uncontrolled) but aging efficacy weak (Foppiani 2025 satisfaction-only LoE IV; strongest RCT evidence is acne scars not aging, Shen 2022); central confound = combination-therapy (PRP/vit-C/exosome co-delivery) prevents monotherapy attribution. verified:true at abstract scope (all primaries not_oa; abstracts read directly from PubMed). clinical-trials-active=5 (CT.gov v2). Backlink added to dermatologic-resurfacing → 2026-06-02
2026-05-31 ingest — seeded phenotypes/intervertebral-disc-degeneration.md + phenotypes/low-back-pain.md (ad-hoc, user-prompted; both verified:false, R25 recency run). Disc page = mechanism anchor (NP senescence/SASP, endplate calcification, D+Q-positive/navitoclax-negative SCAP heterogeneity per Novais 2026); LBP page = clinical-syndrome anchor (mechanical vs radicular, radiographic-pain disconnect per Brinjikji 2015, exercise as best-evidenced mitigation per Hayden 2021 Cochrane). Cross-linked to sarcopenia/osteoarthritis/osteoporosis/bone/skeletal-muscle/exercise. Stub wikilinks surfaced: [[tissues/intervertebral-disc]], [[facet-joints]]. Verifier queued (Brinjikji/Novais/Ghazizadeh PDFs pending DOI lookup) → 2026-05-31
2026-05-31 ingest — seeded studies/corley-2025-semaglutide-epigenetic-aging.md (Nat Commun 2026 RCT; semaglutide slows epigenetic clocks BMI/hsCRP-adjusted in HIV-lipohypertrophy; secondary endpoint; material TruDiagnostic COI); propagated to semaglutide.md (biological-age gap reframed → needs-healthy-population-replication) → 2026-05-31
2026-05-31 ingest — seeded molecules/compounds/tirzepatide.md + studies/surpass-cvot-2025.md (longevity-MD GLP-1 video review; both verified:false); corroborated studies/qin-2026-semaglutide-oa.md human-pilot figures via science-press (kept verified:false); propagated to glp1-agonists.md (SURPASS-CVOT result + link); verified video claims (STEP 9 n=407 not 47; SURPASS-CVOT superiority NOT met, post-hoc HR 0.84) → 2026-05-31
2026-05-31 ingest — seeded processes/senescence-escape.md + processes/senescence-immune-surveillance.md (gap fill from fisetin/senolytic Q&A; both verified:false, R25 recency run); NK/NKG2D added to acronyms; inbound-link propagation from cellular-senescence/disabled-adaptive-immunity/senolytics; verifier follow-up queued (foundational mouse PDFs) → 2026-05-31
2026-05-31 verify — molecules/compounds/fisetin.md formulation subsection full-PDF-verified (Krishnakumar 2022 + Szymczak 2023); corrections: Cmax 23.9-fold (was ~24), AUC units added, CoI disclosure added, Szymczak nanocochleate 141-vs-13-fold internal inconsistency flagged → 2026-05-31
2026-05-31 ingest — molecules/compounds/fisetin.md + Formulation & bioavailability enhancement subsection (Szymczak 2023 animal nano/lipid PK table + Krishnakumar 2022 FF-20 human PK RCT); recorded that best-in-human Cmax ~0.83 µM is ~24-fold below the 20 µM ex-vivo senolytic concentration; “liposomal fisetin” consumer products ≠ validated FF-20; abstract-level verification, verifier follow-up queued → 2026-05-31
2026-05-29 verify — molecules/proteins/s100a8-s100a9.md → verified:true (partial scope: Perera 2025/Garcia 2022/Cho 2026 not OA); 7 corrections: Damo 2013 His27 (not His20), fungal pathogens removed from Damo, Bonora 2022 n corrected (~300→139), HR 2.28 added, Bogdanowicz 2024 design/n corrected (44+30 women), nf-kb-pathway→nf-kb wikilink, Wang 2026 unsourced→no-fulltext-access → 2026-05-29
2026-05-29 verify — molecules/proteins/vsig4.md → verified:true (partial scope); 5 corrections: Hall 2020 body sex-stratified precision added (female PFI r=0.42 p=0.17 not sig); Hall 2020 footnote enriched (3.9-fold, r-values, strain); Vogt 2006 footnote enriched (fold-reductions, absent tissues); Helmy 2006 footnote enriched (C3b specificity, rosetting data); Han 2026 DOI confirmed valid (Crossref) + gap/unsourced removed; Tyshkovskiy four-gene quote verified in paper main text → 2026-05-29
2026-05-29 verify — methods/single-cell-rna-seq.md → verified:true (partial scope); 3 corrections: (1) 10x throughput “~10,000 cells/run”→“~8–10k cells/channel, up to 8 channels”; (2) Smart-seq2 plate “384-well”→“96-well (standard)” + throughput “~384”→“~96 cells/plate” + gap/no-fulltext-access (Picelli 2014 not_oa); (3) Zheng 2017 footnote “68k+ PBMCs + brain cells”→“~68k PBMCs (8 channels, single donor); ~250k total” → 2026-05-29
2026-05-29 verify — molecules/proteins/nrep.md → verified:true (partial scope); 3 corrections: embryonic ground-zero + CR Nrep-specific claims softened + gap-tagged (not confirmed in verified study-page scope); 3 closed-access footnotes (Fujitani 2004, Yao 2016, Chen 2022) tagged gap/no-fulltext-access; Yue 2014/Pan 2002/Badri 2013 PDFs read+verified; UniProt Q16612 confirmed NREP_HUMAN (no namespace collision) → 2026-05-29
2026-05-29 verify — methods/mendelian-randomization.md → verified:true (partial scope); 4 corrections: STROBE-MR item count “24-item”→“20 main+30 sub-items”, STROBE-MR citation “328(22):2261”→“326(16):1614”, Henry 2022 footnote example coloc PP4 removed (method not used; multiverse sensitivity applied), protein-page count 144→146 → 2026-05-29
2026-05-29 verify — methods/wgcna.md → verified:true (partial scope); 3 attribution corrections: (1) dynamicTreeCut re-attributed to Langfelder, Zhang & Horvath 2008 Bioinformatics (btm563), not the WGCNA package paper; (2) Zsummary cutoffs re-attributed to Langfelder et al. 2011 PLoS Comput Biol with new [^langfelder2011] footnote; (3) “moderate” → “weak-to-moderate” per 2011 paper’s language; Langfelder 2008 PDF read end-to-end; Langfelder 2011 pp.1–4 read; Zhang & Horvath 2005 closed-access tagged gap/no-fulltext-access → 2026-05-29
2026-05-29 verify — molecules/proteins/lgals3.md → verified:true (partial scope); 9 corrections: CRD residues 250→248; Henry 2022 n=large→n=3,019/732 HF events; Pan 2024 “consistent across methods” qualified (simple mode non-sig); Wang 2022 + Gou 2023 ORs/CIs added; de Boer 2010 reclassified from prospective cohort to review; Wu 2022 tissue context corrected renal not cardiac; Puigdellívol Mer kinase added; Henderson 2008 enriched; Cheng 2024 meta-analysis (24 cohorts) added as HF biomarker confirmatory evidence → 2026-05-29
2026-05-29 verify — molecules/proteins/gpnmb.md → verified:true (partial scope); corrections: mr-causal-evidence not-tested→partial (2 conflicting PD-specific MR studies found: Li 2025 null, Guo 2026 positive); 560 aa isoform added; banner updated; Saade 2021 + Chen 2024 PDF-verified → 2026-05-29
2026-05-29 verify — model-organisms/macaca-fascicularis.md → verified:true (partial scope); 3 corrections: hESC vs iPSC body-text, Zhang section year 2022/2023→2023, menstrual/AMH DOI wrong (expanim.23-0119→expanim.25-0098) + year 2024→2026; canonical IDs + genome size + Zhang 2023 PDF verified; Yang 2024/Sun 2025 closed-access → 2026-05-29
2026-05-29 verify — molecules/proteins/cst7.md → verified:true (partial scope: GTEx + Open Targets not queried); 6 corrections applied (MW, cathepsin inhibitor target set, Syage “viral control” framing, Daniels Aβ burden regional specificity, druggability rationale, footnote n/methods enriched); Daniels 2023/Syage 2024/Li 2024/Wang 2025 PDFs read; Tyshkovskiy 2026 accepted from verified study page; Baleviciute 2023 closed-access → 2026-05-27
2026-05-29 verify — interventions/blood-product/heterochronic-parabiosis.md → verified:true (partial scope); 7 corrections applied; Conboy 2005, Villeda 2011, Loffredo 2013, Egerman 2015 PDF-verified; Villeda 2014 (failed) + Rebo 2016 (pending) remain gap/no-fulltext-access; Tyshkovskiy 2026 block accepted from verified study page → 2026-05-27
2026-05-27 propagation — Sun 2025 (PMID 40365494; HYAL2 skin RNAi proof-of-concept) added to molecules/compounds/hyaluronic-acid.md (Translational-gap section) + phenotypes/skin-aging.md (new “Hyaluronan turnover and the HYAL2 axis” subsection + therapeutic-landscape pointer); ADDENDUM scopes flipped to “PDF cross-checked — accurate” → 2026-05-27
2026-05-27 verify — HYAL2 batch: molecules/proteins/hyal2.md → verified:true; 2 corrections (acute UVB dose framing 300 mJ/cm² total not per-day; chronic 2-phase protocol detail added); Open Targets GO CC high conf added to druggability; He 2026 AKT direction confirmed correct; all canonical IDs confirmed → 2026-05-27
2026-05-27 ingest — molecules/proteins/hyal2.md (HYAL2 / hyaluronidase-2; user-requested ad-hoc after escin/HA-skin-aging question; anchor source Sun 2025 Front Med) → 2026-05-27
2026-05-27 verify — molecules/compounds/escin.md → verified:true; 6 corrections (WMD CI inversion, trial count, AE frequency, Yang n, Kuznetsov n, elastase added to mechanism) → 2026-05-27
2026-05-27 ingest — escin / horse chestnut seed extract (ad-hoc, venotonic compound) → 2026-05-27
2026-05-26 edit — molecules/compounds/egcg.md add ‘Food-matrix degradation: PPO susceptibility’ subsection (Ottaviani counter-evidence follow-up); EGCG pyrogallol/galloyl ⇒ ≥epicatechin PPO-susceptible; 2 new refs not full-PDF-verified → 2026-05-26
2026-05-26 verify — molecules/proteins/sf3b1.md → verified:true (scoped); 7 corrections (K700E ~55%, CHIP rank 6th, Gumuser 2023 cohort fix, mouse ring-sideroblast removed) → 2026-05-26
2026-05-26 verify — molecules/proteins/jak2.md → verified:true (scoped); 6 corrections + Wang 2025 plaque-erosion-vs-rupture supersession flagged → 2026-05-26
2026-05-26 verify — hypotheses/somatic-mutation-theory-of-aging.md → verified:true (scoped); Szilard 1959 chromosome-inactivation reframing; 7 corrections → 2026-05-26
2026-05-26 verify — methods/duplex-sequencing.md → verified:true (scoped); 6 corrections (HiDEF-seq→PacBio; Lawson 2025 239-gene panel scope) → 2026-05-26
2026-05-26 verify — processes/somatic-mutation-accumulation.md → verified:true; Cagan 2022 fabricated stat + oesophageal clone-density 100× error corrected (relocated from R9) → 2026-05-26
2026-05-26 ingest — somatic mutation accumulation + duplex sequencing (ad-hoc, WGS-tier question) → 2026-05-26
2026-05-26 ingest — 7-day complete-fasting plasma proteome (Pietzner 2024, ad-hoc) → 2026-05-26
2026-05-26 ingest — somatic-mutation-theory hypothesis + JAK2/SF3B1 driver proteins (ad-hoc) → 2026-05-26
2026-05-26 ingest — prolonged-fasting follow-on studies (Commissati 2025 + Dai 2024) → 2026-05-26
2026-05-25 verify — phenotypes/chronic-venous-disease.md exercise bullet; 4 corrections (Turner 2022 / Zhang 2023 disambiguation) → 2026-05-25
2026-05-25 verify — phenotypes/chronic-venous-disease.md Genetics section; 9 corrections (Ahmed 2022 46-loci; FOXC2/Ng 2005 fix) → 2026-05-25
2026-05-25 verify — tissues/veins.md valve sections + interventions/procedural/venous-valve-reconstruction.md; 8 corrections → 2026-05-25
2026-05-25 verify — phenotypes/chronic-venous-disease.md + tissues/veins.md → verified:true; 6 corrections (Criqui 2003 ORs, MMP list, Bonn n) → 2026-05-25
2026-05-25 ingest — chronic venous disease (varicose veins / CVI) + veins tissue → 2026-05-25
2026-05-25 ingest — venous valve deep-dive + artificial venous valves → 2026-05-25
2026-05-25 ingest — CVD genetics section (ad-hoc) → 2026-05-25
2026-05-25 ingest — exercise-for-CVD RCT evidence (ad-hoc) → 2026-05-25
2026-05-25 ingest — CVD progression hypotheses + experiment proposal (ad-hoc) → 2026-05-25
2026-05-23 verify — molecules/proteins/dkk1.md → verified:true (partial); 6 corrections (Purro 2014 review re-attribution) → 2026-05-23
2026-05-23 verify — tissues/bone.md → verified:true (partial); 8 corrections + Farr 2024 Phase-2 RCT supersession → 2026-05-23
2026-05-23 verify — cell-types/osteocytes.md → verified:true; 7 corrections → 2026-05-23
2026-05-23 verify — molecules/proteins/15-pgdh.md → verified:true; 7 corrections (isoform count; druggability-tier 1→2) → 2026-05-23
2026-05-23 verify — studies/bakooshli-2023-15pgdh-nmj-regeneration.md → verified:true; 10 corrections → 2026-05-23
2026-05-23 verify — studies/singla-2025-15pgdh-cartilage-regeneration.md → verified:true; 9 corrections (year 2025→2026; cohort n) → 2026-05-23
2026-05-23 verify — studies/palla-2021-15pgdh-muscle-rejuvenation.md → verified:true; 3 corrections (mouse ages) → 2026-05-23
2026-05-23 ingest — UV filter chemistry (Mexoryl 400 + TriAsorB + Matta 2019/2020 systemic absorption) → 2026-05-23
2026-05-23 ingest — 15-PGDH gerozyme axis (protein + inhibitor + 3 study pages) → 2026-05-23
2026-05-23 verify — 15-PGDH gerozyme axis (5-page verification pass) → 2026-05-23
2026-05-23 ingest — Klotho-FGF23-phosphate axis seeding cluster → 2026-05-23
2026-05-23 verify — phenotypes/osteoporosis.md → 2026-05-23
2026-05-23 verify — pathways/wnt-beta-catenin.md (merged-section verification) → 2026-05-23
2026-05-23 verify — molecules/proteins/osteopontin.md → 2026-05-23
2026-05-23 verify — molecules/proteins/runx2.md → 2026-05-23
2026-05-23 verify — molecules/proteins/fgf23.md → 2026-05-23
2026-05-23 verify — cell-types/endothelial-cells.md → verified:true (partial scope) → 2026-05-23
2026-05-22 seed — interventions/dietary/probiotics.md (ad-hoc, low-gas-strain focus) → R45
2026-05-22 verify — interventions/dietary/probiotics.md → verified:true (partial) → R45
2026-05-21 mechanism-update — SREBP-2/PCSK9/LDLR aging-axis direction corrected (Yang 2024; 4 pages) → 2026-05-21
2026-05-21 propagate — Iwata 2025 / E. americana / bacterial-cancer-therapy cross-linked into MOCs → 2026-05-21
2026-05-21 verify — microbiome/ewingella-americana.md → verified:true; 8 corrections → 2026-05-21
2026-05-21 verify — studies/iwata-2025-ewingella-americana-antitumor.md → verified:true; 3 corrections → 2026-05-21
2026-05-21 verify — interventions/pharmacological/bacterial-cancer-therapy.md → verified:true; 3 corrections → 2026-05-21
2026-05-21 seed — interventions/pharmacological/bacterial-cancer-therapy.md (class page) → 2026-05-21
2026-05-21 seed — microbiome/ewingella-americana.md → 2026-05-21
2026-05-21 seed — studies/iwata-2025-ewingella-americana-antitumor.md → 2026-05-21
2026-05-21 ingest — kane-2025-super-adjuvant-nanoparticles (Cell Reports Medicine) → 2026-05-21
2026-05-21 elevate — kane-2025 → nanoparticle-immunoadjuvants intervention class page → 2026-05-21
2026-05-20 schema R45 — type: experiment + experiments/ directory + matrix-as-blocker-tracker → R45
2026-05-20 R46 — methods/ directory + type: method schema → R46
2026-05-20 ingest — Shin 2025 Metabolism extracellular ReHMGB1 RAGE-JAK/STAT senescence propagation → 2026-05-20
2026-05-20 verify — shin-2025-rehmgb1 (same-day verification pass) → 2026-05-20
2026-05-20 update — glucosepane § “Tissue imaging tools” → 2026-05-20
2026-05-20 ingest — Remesal 2025 Nature Aging neuronal FTL1 cognitive-aging driver (+ ftl1.md) → 2026-05-20
2026-05-20 verify — studies/geronimo-olvera-2026-apoe2-dna-repair-senescence.md → verified:true; NNAT gene-symbol fix → 2026-05-20
2026-05-20 ingest — Gerónimo-Olvera 2026 Aging Cell APOE2 DNA-repair / senescence-resistance → 2026-05-20
2026-05-20 verify — interventions/lifestyle/protein-intake.md → verified:true (partial); 6 corrections → 2026-05-20
2026-05-20 verify — studies/ottaviani-2023-ppo-flavanol-bioavailability.md → verified:true; 9 corrections → 2026-05-20
2026-05-20 seed — interventions/lifestyle/protein-intake.md (15 DOIs; dietary-protein dose home) → 2026-05-20
2026-05-20 verify — IgG Fc glycosyltransferase cluster (b4galt1/st6gal1/fut8/mgat3); 6 corrections → 2026-05-20
2026-05-20 seed — IgG Fc glycosyltransferase cluster (4 protein pages) → 2026-05-20
2026-05-20 verify — processes/igg-fc-glycosylation.md; 8 corrections → 2026-05-20
2026-05-20 seed — processes/igg-fc-glycosylation.md (GlycanAge mechanism page) → 2026-05-20
2026-05-20 verify — R45 three-paper supersession batch (de-decker/cordioprev/matlack); glycolaldehyde + ELISA fixes → 2026-05-20
2026-05-20 seed — R45 three-paper supersession integration (3 study pages + 4 extensions) → 2026-05-20
2026-05-20 verify — natural-AGE-clearance enzyme cluster (fn3k/glo1/methylglyoxal/CML + extension) → 2026-05-20
2026-05-20 ingest — Mijakovac 2026 IgG glycome + mortality + interventions (preprint) → 2026-05-20
2026-05-20 seed — natural-AGE-clearance enzyme cluster (5 pages + extension) → 2026-05-20
2026-05-20 add — acronyms.md (top-level acronym/abbreviation glossary; ~280 curated entries A–Z; linked from index.md)
2026-05-19 seed — processes/pentosidine.md + cross-species AGE kinetics (glucosepane + H. glaber) → 2026-05-19
2026-05-19 verify — processes/pentosidine.md + glucosepane / H. glaber AGE sections; 7 corrections → 2026-05-19
2026-05-19 brainstorm — skin-age-reversal-45-to-30 → 2026-05-19
2026-05-19 verify — aldh1a1 protein page (post-R44; 5 PDFs read; 8 corrections — HGNC 405→402; Choudhary 2005 DOI corrected (iovs.04-0550→iovs.04-0120); Pequerul 2020 footnote first author corrected (Lovaas→Pequerul) + volume corrected (689→681); NCT-501 attribution to Pequerul 2020 removed (#gap/unsourced); Martirosyan 2024 “28 genes depleted in neuronal subpopulations” corrected to “28 shared markers across TH-enriched neuronal + glial depleted populations”; DEAB described as broad ALDH inhibitor not ALDH1A1-selective; Poulin 2014 MPTP quantitative data added (66.2% DA1A loss vs 39.1% DA1B, p=0.001); supersession check: no supersession candidates found; verified: true with partial scope for Fujiwara 2007/Zhang 2010/Yasmeen 2011/Napoli 2017) → R44
2026-05-19 verify — aldh1a2 protein page (post-R44; Takano 2020 + Shepherd 2018 + Kelly 2016 PDFs read; 3 key corrections: Takano 2020 strain C57BL/6→BALB/c, age ranges corrected to 18–27 mo / 8–12 wk, n ~10/group→3–6/group; Shepherd 2018 rs12915901 clarified as intronic functional SNP for AEI (primary GWAS signal rs3204689), AEI quantified, 0.3-fold OA vs non-OA expression added; 5 footnotes marked not_oa; Wu 2008 PDF unresolvable tagged gap/no-fulltext-access; verified: true with partial scope) → R44
2026-05-19 verify — Menendez Vazquez 2025 MitraSolo/MitraCluster biomarker page (full PDF read 10 pages, PMC12820032; 8 corrections — MAE “~4 yr” → MitraSolo 4.09 yr / MitraCluster 4.00 yr exact; RMSE/MAD/R² added; CpG counts null → 3,831 / 14,089; architecture null → PCA-based ElasticNet; cohort demographics fully filled (ages 18–90, all Fitzpatrick types/ethnicities, n=387/75 split); Moqri affiliation Stanford → BWH/Harvard Medical School; Yamanaka experiment detailed (NHEK→iPSC, predicted age 48.8→6.9/6.2 yr); intra-individual variation ”< 2 yr” → exact 1.76/1.67 yr; archive status updated to downloaded; supersession check: no supersession candidates; verified: true) → R44
2026-05-19 verify — boersma-2025-saf-cancer-incidence study page (full PDF read 10 pages; 6 corrections — added intermediate Model 2 HR 1.15 [1.09–1.21]; Model 3 n corrected 77,961→72,038 due to missing covariates; covariate list completed with alcohol intake and pack-years of smoking; cancer registry source corrected to Palga not Netherlands Cancer Registry; liver cancer significance corrected p<0.001→p<0.01; T2DM subgroup HRs added; site-specific section expanded from Fig. 1 with case counts and significance tiers; competing risk analysis result added; follow-up IQR added; supersession check: no supersession candidates 2025–2026; verified: true) → R44
2026-05-19 verify — lin-2005-ce-ferulic-photoprotection study page (full PDF read 7 pages; 5 corrections — PMID 16170318→16185284, quote location p.830→p.829 Discussion, caspase-7 omitted throughout corrected, two wikilink path-prefix fixes; verified: true) → R44
2026-05-19 post-R44 batch B — 4-agent parallel batch (2 verifiers + 2 seeders): SOD2 verified (4 corrections — most significant: ROMAN Phase 3 primary endpoint was MET p=0.045, seeder claimed failed; K68/K122 primary/secondary hierarchy removed); arterial-stiffening verified (8 corrections — Mitchell 2010 HR 14% per m/s → 48% per SD; Jennings 2019 was AIx@75 not cfPWV; Clayton 2023 effect 15% → 20%); ferulic-acid seeded (ChEMBL ID corrected CHEMBL66653 → CHEMBL32749 via InChIKey lookup; 3 2025-2026 RCTs integrated); skin-methylation-clocks class MOC seeded at biomarkers/ per R35 precedent → R44
2026-05-19 post-R44 batch A — 7 atomic pages seeded (ALDH1A1/2/3 + SOD2 + arterial-stiffening + Menendez Vazquez 2025 MitraSolo/MitraCluster + Boersma 2025 SAF-cancer) + 2 propagation passes (35 edits across 20 files: RALDH/SOD2/arterial-stiffening/Menendez/Boersma cross-links + Allen 2023/Mansouri 2025/Bienkowska 2026 propagation to STAC class + NAD precursors); all 7 new pages verified: false; PubMed-confirmed citations for Mansouri 2025 + Allen 2023 + Bienkowska 2026 → R44
2026-05-19 verify — falckenhayn-2024-dhm-dnmt-inhibitor study page (post-R44; full PDF read 13 pages; 7 corrections — author count confirmed 18 (not 17); in-vivo arm confirmed split-site design + suction-blister sampling; gene-expression arm age range 50–65 yr added; 3D model DHM dose 20 µM + 6-wk treatment duration added; wrinkle-score predictor result Δ−2.13 units added to findings table; myricetin IC₅₀ 43.37 µM comparator added; gap/needs-pdf-verification tags removed where resolved; supersession check: 3 2024–2026 papers found, all supportive, no supersession; verified: true) → R44
2026-05-19 verify — hughes-2013-sunscreen-photoaging study page (abstract-level; closed-access not_oa; 3 corrections — age range “25–55” → “younger than 55” in TL;DR and Methods (lower bound unconfirmed at abstract level), beta-carotene description softened from “no benefit” to “no overall effect” matching abstract phrasing, subgroup contrast by baseline severity added from abstract; verified: true with partial scope) → R44
2026-05-19 verify — Qi 2026 campaign-initiator study page (post-close; PDF read end-to-end from user-provided local copy; 6 corrections — DNAm-age −2.1→−2.08 yr, CV metric label corrected, correlation r=0.314 p=0.025, array platform EPICv2, Table 1 n values, sunscreen partial-correlation analysis added; verified: true) → R44
2026-05-19 verify — Malassezia microbe page (R44; 3 PDFs read + 1 PMC full text; 12 corrections — genome size 7.1→9 Mb, lipase count 8→14, Kim n 118→61 + ages 20–66→19–28/60–63, Jo n 10/18→14/19 + body sites 14→10, Han n added 95 + CI + M. sympodialis prev, species count 18–21→19, M. restricta aging directionality corrected; Sparber/Dawson/Sowell partial-access noted; verified: true) → R44
2026-05-19 verify — skin-microbiome-aging-shifts process page (R44; 6 PDFs read; 14 corrections — Shibagaki n 74→37 + age range 21–37→23–37 + Staphylococcus forearm direction corrected + oral species count 38 total/16 oral clarified; Kim n ~40→61 + age range 19–28/60–63→20–29/60–69 + Malassezia directionality clarified; Wu n=65 + group breakdown added; Huang multi-country scope corrected + MAE framing clarified; Swaney n=59 + p-values added; Christman microbiome analysis n=12 caveat + NCT added; Staphylococcus table direction corrected to site-dependent; 16S variable region methodology section corrected; Howard 2022 + Zhang 2024 gap/no-fulltext-access tagged; verified: true) → R44
2026-05-19 verify — cutibacterium-acnes microbe page (R44; 9 PDFs read; Jung 2024 n corrected 86→60 + method 16S→metagenome; Swaney 2025 n=59 added; Podbielski shoulder→deep-seated infection correction; Trompezinski BGM complex attribution corrected; Yu 2024 first author corrected; 11 corrections total) → R44
2026-05-19 verify — dermatologic-resurfacing intervention page (R44; 9 papers abstract-level; 15 corrections — Robati DOI wrong jocd.12908→jocd.13440, Foppiani n 34→21 studies/723 pts, Vassão n 12→21 articles, Sales n 18→16 studies, Haykal n=1087/26 fabricated→45 trials, Modena FACE-Q outcome unconfirmed, de Filippi Sartori year/design/n/biopsy-timing corrected, Manstein no animal subjects + re-epi 24–48h→24h + 1.5µm prototype note) → R44
2026-05-19 verify — AGE crosslink breakers intervention page (R44; Vasan 2000 full PDF — wrong model organism dogs not rhesus monkeys, wrong first author; PubChem CID corrected 9904184→216305; Streeter 2020 mouse not human; pentosinane crosslink nature clarified; 7 corrections total) → R44
2026-05-19 verify — lactic acid compound page (R44; Almeman 2024 full PDF; Stiller 1996 + Smith 1996 PubMed abstracts; 4 corrections — Smith 1996 design reclassified from RCT to comparative, patient description corrected, comparison table updated, gap tag added) → R44
2026-05-19 verify — topical-estrogens intervention page (R44; 7 anchor citations cross-checked via PubMed/Crossref; Moraes 2009 n corrected to 36; Ashcroft 1999 study design clarified; clinical-stage corrected phase-3→phase-2 per R24; 3 new 2026 papers DOIs/authors confirmed; Javaheri 2026 archive gap noted) → R44
2026-05-19 verify — glycolic acid compound page (R44; Lin 2025 NMA full PDF read — 5 corrections; Almeman 2024 full PDF read — KLK5/KLK7 misattribution corrected; Faghihi 2011 PMID confirmed; canonical IDs confirmed PubChem REST) → R44
2026-05-19 verify — salicylic acid compound page (R44; canonical IDs confirmed PubChem REST; Liu 2020 wording corrected; PMC full text read) → R44
2026-05-19 verify — skin-autofluorescence-age-reader biomarker page (R43; 4 PDFs read; 1 critical misattribution corrected) → R43
2026-05-19 verify — Qi 23k Epidermis Clock biomarker page (R43; partial scope — full PDF blocked by Springer auth) → R43
2026-05-19 verify — Bormann Epidermis Clock biomarker page (R43) → R43
2026-05-19 verify — TapeLift epigenetic clock biomarker page (R43) → R43
2026-05-19 R42 close — topical antioxidants + UV protection (6 pages) → R42
2026-05-19 verify — ascorbic acid compound page (R42) → R42
2026-05-19 verify — niacinamide compound page (R42 retry) → R42
2026-05-19 verify — UV protection intervention page (R42) → R42
2026-05-19 verify — alpha-tocopherol compound page (R42) → R42
2026-05-19 verify — dihydromyricetin compound page (R42) → R42
2026-05-19 verify — resveratrol compound page (R42) → R42
2026-05-19 R41 close — retinoid cluster + class MOC (7 pages) → R41
2026-05-19 verify — molecules/compounds/retinaldehyde.md (R41 retinoid cluster) → R41
2026-05-19 verify — molecules/compounds/tazarotene.md (R41 retinoid cluster) → R41
2026-05-19 verify — molecules/compounds/adapalene.md (R41 retinoid cluster) → R41
2026-05-19 verify — molecules/compounds/tretinoin.md (R41 retinoid cluster anchor) → R41
2026-05-19 verify — molecules/compounds/retinol.md (R41 retinoid cluster) → R41
2026-05-19 verify — interventions/pharmacological/retinoids.md (R41 class MOC) → R41
2026-05-19 R40 close — effector proteins + dermal-matrix + wound-healing (12 pages) → R40
2026-05-19 verify — molecules/proteins/lox.md → R40
2026-05-19 R40 verify — molecules/proteins/fbn1.md → R40
2026-05-19 R40 verify — molecules/proteins/eln.md → R40
2026-05-19 R40 verify — molecules/proteins/col3a1.md → R40
2026-05-19 R40 verify — molecules/proteins/kit.md → R40
2026-05-19 R40 verify — molecules/proteins/mmp-9.md → R40
2026-05-19 R40 verify — processes/wound-healing.md → R40
2026-05-19 R40 verify — molecules/proteins/col1a1.md → R40
2026-05-19 R40 verify — molecules/proteins/mmp-1.md → R40
2026-05-19 R40 verify — molecules/proteins/timp-1.md → R40
2026-05-19 R39 close — foundational primary-source studies (12 pages) → R39
2026-05-19 verify | studies/krutmann-2017-skin-aging-exposome.md (R39 full-PDF verification) → R39
2026-05-19 verify | studies/rodriguez-paredes-2026-tapelift-clock.md (R39 full-PDF verification) → R39
2026-05-19 verify | studies/inomata-2009-melanocyte-stem-cell-atm.md (R39 full-PDF verification) → R39
2026-05-19 verify | studies/fisher-2009-collagen-fragmentation-mmp.md (R39 full PDF verification) → R39
2026-05-19 verify | studies/velarde-2012-mitochondria-skin-senescence.md (R39 full-PDF verification) → R39
2026-05-19 verify | studies/sumita-2018-tretinoin-photoaging.md (R39 n/pages metadata correction) → R39
2026-05-19 verify | studies/bormann-2016-epidermis-clock.md (R39 full PDF verification) → R39
2026-05-19 verify | studies/kovacs-2010-fibroblast-solar-lentigo.md (R39 growth-factor correction) → R39
2026-05-19 verify | studies/purohit-2016-smad3-fibroblasts.md (R39 metadata correction) → R39
2026-05-19 verify | studies/fisher-1996-photoaging-ap1-mmp.md (R39 canonical resolution) → R39
2026-05-19 verify — hattori-2004-scf-solar-lentigo → R38
2026-05-19 R38 close — skin-aging cluster substrate (8 tissue + cell-type pages) → R38
2026-05-19 verify | cell-types/langerhans-cells.md → R36
2026-05-19 verify | tissues/skin.md → R36
2026-05-19 verify | cell-types/melanocyte-stem-cells.md → R36
2026-05-19 verify | cell-types/melanocytes.md → R36
2026-05-19 verify | cell-types/dermal-fibroblasts.md → R36
2026-05-19 verify | tissues/dermis.md → R36
2026-05-19 verify | cell-types/keratinocytes.md → R36
2026-05-19 verify | tissues/epidermis.md → R36
2026-05-18 ingest | berberine compound page + 7 study pages + 5 propagation passes → R36
2026-05-18 verify | tretowicz-2026-blood-nad-stable-aging + nad-blood-biomarker (full-PDF cross-check) → R36
2026-05-15 verify+propagate | Yang 2003 footnote + GlycoSENS cross-references → R36
2026-05-15 update | processes/advanced-glycation-end-products.md + processes/glucosepane.md — AGE-breaker preclinical landscape → R36
2026-05-14 verify | frameworks/interventions-testing-program.md → R36
2026-05-14 verify | model-organisms/caenorhabditis-elegans.md — worm-specific confounds section (three new citations) → R36
2026-05-14 follow-up pass | C. elegans + ITP + hyperfunction-synthesis + Garner/Garland → R36
2026-05-14 verify | model-organisms/mus-musculus (4-citation PDF cross-check) → R36
2026-05-14 ingest | hypotheses/translation-failure-of-aging-interventions → R36
2026-05-14 ingest | interventions/pharmacological/ppara-agonists → R36
2026-05-14 ingest | studies/coleman-2025-triad-protocol → R36
2026-05-14 ingest | studies/creevy-2022-dog-aging-project → R36
2026-05-14 verification | canis-lupus-familiaris → R36
2026-05-14 ingest | model-organisms/canis-lupus-familiaris → R36
2026-05-13 verify | processes/mitochondrial-rna-leakage.md → R36
2026-05-13 sweep | type-I IFN signaling cluster completion (12-page batch + schema R36) → R36
2026-05-13 verify | molecules/proteins/irf9.md → R34
2026-05-13 verify | molecules/proteins/stat2.md → R34
2026-05-13 verify | molecules/proteins/ifnar1.md → R34
2026-05-13 verify | molecules/proteins/irf7.md → R34
2026-05-13 verify | pathways/tlr3-trif-pathway.md → R34
2026-05-13 verify | pathways/rig-i-mavs-pathway.md → R34
2026-05-13 verify | molecules/proteins/mavs.md → R34
2026-05-13 verify | molecules/proteins/stat1.md → R34
2026-05-13 verify | molecules/proteins/jak1.md → R34
2026-05-13 verify | molecules/proteins/tyk2.md → R34
2026-05-13 verify | molecules/proteins/ifnar2.md → R34
2026-05-13 schema | R34 mouse-ortholog formalized + R35 type:pathway extensions → R34
2026-05-13 verify | pathways/type-i-interferon-signaling.md → R37
2026-05-13 verify | studies/bastard-2021-anti-ifn-autoantibody-age-prevalence.md → R37
2026-05-13 verify | molecules/compounds/amlexanox.md → R37
2026-05-13 verify | molecules/proteins/ikbke.md → R37
2026-05-13 ingest | chen-2025 NMR cGAS follow-on batch (5 pages + propagation) → R37
2026-05-13 verify | molecules/proteins/irf3.md → R37
2026-05-13 verify | molecules/proteins/fancd2.md → R37
2026-05-13 verify | molecules/proteins/palb2.md → R37
2026-05-12 ingest | Chen et al. 2025 Science — naked-mole-rat cGAS HR-repair (cGAS dual-role + DNA-repair reframe) → R37
2026-05-13 verify — studies/zhen-2023-trim41-cgas-l1.md → R37
2026-05-12 verify — molecules/compounds/hyaluronic-acid.md → R37
2026-05-12 verify — molecules/proteins/cd44.md → R37
2026-05-12 verify — molecules/proteins/has2.md → R37
2026-05-12 verify — studies/zhang-2023-nmrhas2-mouse-healthspan.md → R37
2026-05-09 verify — molecules/compounds/patisiran.md → R37
2026-05-09 verify — molecules/compounds/acoramidis.md → R37
2026-05-09 verify — molecules/compounds/tafamidis.md → R37
2026-05-09 verify — molecules/compounds/donanemab.md → R37
2026-05-09 verify — molecules/compounds/lecanemab.md → R37
2026-05-09 verify — hypotheses/longevity-escape-velocity.md → R37
2026-05-09 verify — processes/glucosepane.md → R37
2026-05-09 verify — processes/lipofuscin.md → R37
2026-05-09 ingest + propagate — bempedoic acid / ezetimibe / mevalonate / MTP (batch 4, 4 pages) → R37
2026-05-09 verify — pathways/mevalonate-pathway.md → R37
2026-05-09 verify — molecules/compounds/ezetimibe.md → R37
2026-05-09 verify — molecules/compounds/bempedoic-acid.md → R37
2026-05-09 verify — molecules/proteins/mtp.md → R37
2026-05-09 ingest + propagate — Lp(a)/statins/ApoE/LPL (batch 3, 4 pages) → R37
2026-05-09 verify — molecules/proteins/lpl.md → R37
2026-05-09 verify — molecules/proteins/apoe.md → R37
2026-05-09 verify — molecules/proteins/lpa.md → R37
2026-05-09 ingest + propagate — lipid-lowering target triangle completed (batch 2, 3 pages) → R37
2026-05-09 verify — lipoprotein-metabolism pathway page → R37
2026-05-09 ingest + propagate — dietary-fat → ApoB → CV-event mechanistic chain (5-page batch) → R37
2026-05-09 verify — molecules/proteins/ldlr.md → R37
2026-05-09 verify — phenotypes/familial-hypercholesterolemia.md → R37
2026-05-09 verify — molecules/proteins/apob.md → R37
2026-05-09 verify — interventions/pharmacological/statins.md → R37
2026-05-09 verify — molecules/proteins/srebp-2.md → R37
2026-05-09 R37 close — remaining R35-Stage2 + R36 forward queue (20 pages) → R37
2026-05-09 verify — molecules/proteins/growth-hormone-receptor.md → R35
2026-05-09 verify — molecules/proteins/c-met.md → R35
2026-05-09 verify — molecules/proteins/vegfr2.md → R35
2026-05-09 verify — molecules/proteins/enos.md → R35
2026-05-09 verify — biomarkers/glycanage-2017.md → R35
2026-05-09 verify — molecules/proteins/mc3r.md → R35
2026-05-09 verify — pathways/camp-signaling.md → R35
2026-05-09 verify — pathways/pomc-processing.md → R35
2026-05-09 verify — molecules/proteins/hgf.md → R35
2026-05-09 verify — molecules/compounds/colchicine.md → R35
2026-05-09 verify — molecules/proteins/mc5r.md → R35
2026-05-09 verify — processes/melanogenesis.md → R35
2026-05-09 verify — pathways/trkb-pathway.md → R35
2026-05-09 verify — pathways/spm-pathway.md → R35
2026-05-09 verify — pathways/neurotrophin-signaling.md → R35
2026-05-09 verify — molecules/proteins/pomc.md → R35
2026-05-09 verify — molecules/proteins/il-6.md → R35
2026-05-09 verify — melanocortin-system.md (MOC) → R35
2026-05-09 verify — mc4r.md → R35
2026-05-09 verify — mc1r.md → R35
2026-05-09 verify — setmelanotide.md → R35
2026-05-09 verify — mots-c-peptide.md → R35
2026-05-09 R35-Stage2 + R36-followup close — biomarkers + parent proteins/receptors → R35
2026-05-09 verify — molecules/proteins/fpr2.md → R36
2026-05-09 verify — biomarkers/vo2max-biomarker.md → R36
2026-05-09 verify — biomarkers/homa-ir-biomarker.md → R36
2026-05-09 verify — molecules/proteins/ghsr.md → R36
2026-05-09 verify — biomarkers/grip-strength-biomarker.md → R36
2026-05-09 verify — biomarkers/lbp-biomarker.md → R36
2026-05-09 verify — molecules/proteins/alpha-msh.md → R36
2026-05-09 verify — biomarkers/nfl-biomarker.md → R36
2026-05-09 verify — molecules/proteins/bdnf.md → R36
2026-05-09 verify — biomarkers/nlr-biomarker.md → R36
2026-05-09 verify — biomarkers/il-6-biomarker.md → R36
2026-05-09 verify — biomarkers/igf-1-biomarker.md → R36
2026-05-09 verify — biomarkers/chip-clonal-hematopoiesis-biomarker.md → R36
2026-05-09 R36 close — peptide-therapeutics cluster (12 compounds + CAMP parent + class MOC) → R36
2026-05-09 verify | molecules/proteins/camp → R34
2026-05-09 verify | molecules/compounds/ll-37 → R34
2026-05-09 verify | molecules/compounds/kpv → R34
2026-05-09 verify | molecules/compounds/melanotan-ii → R34
2026-05-09 verify | molecules/compounds/semax → R34
2026-05-09 verify | molecules/compounds/mk-677 → R34
2026-05-09 verify | molecules/compounds/mots-c → R34
2026-05-09 verify | molecules/compounds/dsip → R34
2026-05-09 verify | molecules/compounds/dihexa → R34
2026-05-09 verify | molecules/compounds/epitalon → R34
2026-05-09 verify | molecules/compounds/ghk-cu → R34
2026-05-09 verify | molecules/compounds/tb-500.md → R34
2026-05-09 verify | molecules/compounds/bpc-157 → R34
2026-05-08 seed | molecules/compounds/vitamin-k2.md → R34
2026-05-08 verify | molecules/compounds/vitamin-k2.md → R34
2026-05-08 ingest | GLP-1 RAs in osteoarthritis (Meurot 2022 + Qin 2026) → R34
2026-05-08 resolution | tier-1 → tier-2 re-rating (6 protein pages) → R34
2026-05-08 R34 backfill | bucket cleared (59/59 pages stamped) → R34
2026-05-08 propagation | post-batch-2 propagation pass (R34 backfills) → R34
2026-05-08 recency | dasatinib + quercetin (R34 backfill batch 2) → recency
2026-05-08 propagation | post-batch-1 propagation pass (R34 backfills) → R34
2026-05-08 recency | rapamycin RAPA-EX-01 incorporation (R34 backfill — first batch) → recency
2026-05-08 R34 | lint cleanup + framework wiring (housekeeping) → R34
2026-05-07 verify | molecules/compounds/akkermansia-supplementation → R32
2026-05-07 verify | interventions/dietary/postbiotics → R32
2026-05-07 verify | interventions/dietary/prebiotics → R32
2026-05-07 verify | interventions/dietary/fmt → R32
2026-05-07 verify | microbiome/bifidobacterium → R32
2026-05-07 verify | model-organisms/loxodonta-africana → R32
2026-05-07 verify | microbiome/gut-microbiome-aging-shifts → R32
2026-05-07 verify | pathways/lps-tlr4-nfkb → R32
2026-05-07 verify | processes/gut-barrier → R32
2026-05-07 verify | pathways/fgf-signaling → R32
2026-05-07 verify | allele-selective-oligonucleotides → R32
2026-05-07 verify | model-organisms/balaena-mysticetus → R32
2026-05-07 ingest | allele-selective-oligonucleotides → R32
2026-05-07 ingest | balaena-mysticetus → R32
2026-05-07 ingest | loxodonta-africana → R32
2026-05-07 ingest | intervention-by-target-immunogenicity → R32
2026-05-07 verify | disabled-adaptive-immunity → R32
2026-05-07 ingest | disabled-adaptive-immunity (ad-hoc seed, user-requested) → R32
2026-05-07 verify | cherry-angioma → R32
2026-05-07 ingest | cherry-angioma (ad-hoc seed, user-requested) → R32
2026-05-07 R32 — DNA-repair pathway completion (DONE; 15/15 pages seeded + verified) → R32
2026-05-07 verify — molecules/proteins/atr.md → R31
2026-05-07 verify — molecules/proteins/mrn-complex.md → R31
2026-05-07 verify — interventions/pharmacological/dna-pkcs-inhibitors.md → R31
2026-05-07 verify — molecules/proteins/mlh1.md → R31
2026-05-07 verify — interventions/pharmacological/parp-inhibitors.md → R31
2026-05-07 verify — molecules/proteins/rpa.md → R31
2026-05-07 verify — molecules/proteins/xpf.md → R31
2026-05-07 verify — molecules/proteins/msh2.md → R31
2026-05-07 verify — molecules/proteins/lig1.md → R31
2026-05-07 verify — molecules/proteins/brca2.md → R31
2026-05-07 verify — molecules/proteins/polb.md → R31
2026-05-07 verify — molecules/proteins/ape1.md → R31
2026-05-07 verify — molecules/proteins/pcna.md → R31
2026-05-07 verify — molecules/proteins/xrcc1.md → R31
2026-05-07 R31b-β — Histone modification + sirtuin family + HDAC inhibitors (DONE; 5/5 pages seeded + verified) → R31
2026-05-07 verify — molecules/proteins/sirt7.md → R31
2026-05-07 verify — molecules/proteins/sirt2.md → R31
2026-05-07 verify — processes/histone-acetylation.md → R31
2026-05-07 verify — processes/histone-modification.md → R31
2026-05-07 verify — interventions/pharmacological/hdac-inhibitors.md → R31
2026-05-07 R31b-α — DNA methylation cluster (DONE; 5/5 pages seeded + verified) → R31
2026-05-07 verify — molecules/proteins/dnmt1.md → R31
2026-05-07 verify — molecules/proteins/nanog.md → R31
2026-05-07 R31 — Epigenetic alterations deepening (DONE; 5/5 pages seeded + verified) → R31
2026-05-07 verify — schooling-2025-mr-epigenetic-clock-lifespan → R30
2026-05-07 verify — hdac-class-page → R30
2026-05-07 verify — lu-2020-osk-vision-restoration → R30
2026-05-07 verify — yang-2023-epigenetic-information-loss → R30
2026-05-07 verify — ocampo-2016-partial-reprogramming → R30
2026-05-07 R30 — Mitochondrial dynamics + biogenesis (DONE; 5/5 pages seeded + verified) → R30
2026-05-07 verify — molecules/proteins/nrf2.md → R29
2026-05-07 verify — molecules/proteins/miro2.md → R29
2026-05-07 verify — processes/mitohormesis.md → R29
2026-05-07 verify — molecules/proteins/nrf1.md → R29
2026-05-07 verify — processes/mtdna.md → R29
2026-05-07 R29 — Telomere biology completion (DONE; 10/10 pages seeded + verified) → R29
2026-05-07 verify | interventions/pharmacological/telomerase-activators.md → R25
2026-05-07 verify | molecules/proteins/tpp1.md → R25
2026-05-07 verify | molecules/proteins/dkc1.md → R25
2026-05-07 verify | molecules/proteins/tin2.md → R25
2026-05-07 verify | molecules/proteins/trf2.md → R25
2026-05-07 verify | molecules/proteins/pot1.md → R25
2026-05-07 verify | processes/replicative-senescence.md → R25
2026-05-07 verify | molecules/proteins/terc.md → R25
2026-05-07 lint → lint
2026-05-07 verify | tak1 → R25
2026-05-07 verify | myd88 → R25
2026-05-07 verify | traf6 → R25
2026-05-07 verify | hsp90 → R25
2026-05-07 verify | il-1-signaling + nf-kb cross-fix → R25
2026-05-07 verify | anakinra → R25
2026-05-07 verify | unfolded-protein-response → R25
2026-05-07 verify | waziry-2023 study → R25
2026-05-06 verify | interventions/lifestyle/methionine-restriction.md → R25
2026-05-06 verify | interventions/lifestyle/time-restricted-eating.md → R25
2026-05-06 verify | interventions/lifestyle/heat-exposure.md → R25
2026-05-06 verify | interventions/pharmacological/nad-precursors.md → R25
2026-05-06 verify | interventions/pharmacological/ampk-activators.md → R25
2026-05-06 verify | interventions/gene-therapy/crispr-base-editing-pcsk9.md → R25
2026-05-06 verify | interventions/gene-therapy/aav-klotho.md → R25
2026-05-06 verify | interventions/gene-therapy/aav-follistatin.md → R25
2026-05-06 verify | interventions/gene-therapy/aav-osk.md → R25
2026-05-06 verify | interventions/stem-cell-therapy/hematopoietic-stem-cell-transplantation.md → R25
2026-05-06 verify | interventions/stem-cell-therapy/in-vivo-partial-reprogramming-therapy.md → R25
2026-05-06 verify | interventions/stem-cell-therapy/ipsc-derived-cell-therapy.md → R25
2026-05-06 verify | molecules/proteins/caspase-1.md → R25
2026-05-06 verify | cell-types/astrocytes.md → R25
2026-05-06 verify | molecules/proteins/gsdmd.md → R25
2026-05-06 verify | molecules/proteins/asc.md → R25
2026-05-06 verify | processes/pyroptosis.md → R25
2026-05-06 verify | cell-types/neurons.md → R25
2026-05-06 verify | molecules/proteins/asxl1.md → R25
2026-05-06 verify | molecules/proteins/dnmt3a.md → R25
2026-05-06 verify | hypotheses/mitohormesis.md → R25
2026-05-06 verify | molecules/proteins/fgf21.md → R25
2026-05-06 verify | molecules/proteins/myostatin.md → R25
2026-05-06 verify | molecules/proteins/hsf1.md → R25
2026-05-06 verify — molecules/compounds/coq10.md → R25
2026-05-06 verify | molecules/proteins/pcsk9.md → R25
2026-05-06 verify — molecules/compounds/paroxetine.md → R25
2026-05-06 verify — molecules/proteins/asm.md → R25
2026-05-06 verify — molecules/proteins/mid51.md (R25 Tier B) → R25
2026-05-06 verify — molecules/proteins/fis1.md (R25 Tier B) → R25
2026-05-06 verify — molecules/proteins/mid49.md (R25 Tier B) → R25
2026-05-06 verify — molecules/proteins/mff.md (R25 Tier B) → R25
2026-05-06 verify — molecules/proteins/yme1l.md (R25 Tier B) → R25
2026-05-06 verify — molecules/proteins/il-18.md (R25 Tier B) → R25
2026-05-06 verify — molecules/proteins/il-1a.md (R25 Tier B; partial PDF pass) → R25
2026-05-06 verify — molecules/proteins/il-1r1.md (R25 Tier B; partial PDF pass) → R25
2026-05-06 verify — cell-types/fibroadipogenic-progenitors.md (full PDF pass) → R25
2026-05-06 verify — tissues/heart.md (full PDF re-pass) → R25
2026-05-06 verify — cell-types/fibroadipogenic-progenitors.md → R25
2026-05-06 verify — molecules/proteins/oma1.md (R25 Tier B) → R25
2026-05-06 verify — molecules/compounds/elamipretide.md → R17
2026-05-06 verify — pathways/heat-shock-response.md → R17
2026-05-06 verify — tissues/heart.md → R17
2026-05-06 synthesis — production-vs-clearance framing for senescence → R17
2026-05-06 sop-update — finding-druggability.md (Open Targets schema migration) → R17
2026-05-05 verify — molecules/proteins/ku70-ku80.md → R17
2026-05-05 verify — pathways/nucleotide-excision-repair.md → R17
2026-05-05 verify — molecules/proteins/parp1.md → R17
2026-05-05 verify — pathways/homologous-recombination.md → R17
2026-05-05 verify — molecules/proteins/shelterin.md → R17
2026-05-05 verify — molecules/proteins/gdf15.md → R17
2026-05-05 verify — molecules/proteins/gdf11.md → R17
2026-05-05 verify — molecules/proteins/tert.md → R17
2026-05-05 verify — biomarkers/phenoage-2018.md → R17
2026-05-05 verify — biomarkers/lehallier-proteomic-clock-2019.md → R17
2026-05-05 verify — biomarkers/grimage-2019.md → R17
2026-05-05 verify — biomarkers/hannum-clock-2013.md → R17
2026-05-05 verify — biomarkers/dunedinpace-2022.md → R17
2026-05-05 verify — biomarkers/horvath-clock-2013.md → R17
2026-05-05 verify — biomarkers/frailty-index.md → R17
2026-05-05 verify — biomarkers/telomere-length-leukocyte.md → R17
2026-05-05 Round 17 — Biomarker layer seeded (DONE) → R17
2026-05-05 Round 15 — Hallmark causality graph synthesis MOC (DONE) → R15
2026-05-05 Round 14 — Schema additions for synthesis MOCs (DONE) → R14
2026-05-05 Round 13 batch summary (post-R12 lint highest-leverage adds) → R12
2026-05-05 verify | pathways/scfa-signaling.md → R12
2026-05-05 verify | molecules/proteins/lamp2.md → R12
2026-05-05 verify | molecules/proteins/pgc-1alpha.md → R12
2026-05-05 verify | molecules/proteins/il-1b.md → R12
2026-05-05 verify | molecules/proteins/hsp70.md → R12
2026-05-05 verify | frameworks/apoptosenes.md → R12
2026-05-05 ingest | scfa-signaling (pathway) → R12
2026-05-05 Round 12 batch summary (high-leverage post-lint adds + R10e/R10f close-out) → R12
2026-05-05 verify | canakinumab → R10
2026-05-05 verify | akkermansia-muciniphila → R10
2026-05-05 verify | clonal-hematopoiesis → R10
2026-05-05 verify | hair-greying → R10
2026-05-05 verify | skin-aging → R10
2026-05-05 verify | androgenetic-alopecia → R10
2026-05-05 verify | c-myc → R10
2026-05-05 verify | ear-nose-enlargement → R10
2026-05-05 verify | creatine → R10
2026-05-05 verify | sox2 → R10
2026-05-05 verify | oct4 → R10
2026-05-05 verify | egcg → R10
2026-05-05 verify | taurine → R10
2026-05-04 verify | round-10d → R10
2026-05-04 ingest | cardiac-fibroblasts (round-10d) → R10
2026-05-04 ingest | ep300 (round-10d) → R10
2026-05-04 ingest | hsc70 (round-10d) → R10
2026-05-04 ingest | lipa (round-10d) → R10
2026-05-04 ingest | partial-reprogramming (Round 10d) → R10
2026-05-04 ingest | deptor (round-10d) → R10
2026-05-04 ingest | nampt (round-10d) → R10
2026-05-04 ingest | opa1 (round-10d) → R10
2026-05-04 ingest | cgas-sting (round-10d) → R10
2026-05-04 ingest | round-10d-targeted-adds → R10
2026-05-04 ingest | mitochondrial-biogenesis (round-10d) → R10
2026-05-04 ingest | trem2 → R10
2026-05-04 verify | miro1 → R10
2026-05-04 verify | vdac1 → R10
2026-05-04 verify | skeletal-muscle + myocardium (tissue stubs, light verification) → R10
2026-05-04 verify | smac-diablo → R10
2026-05-04 verify | atg16l1 → R10
2026-05-04 verify | fip200 → R10
2026-05-04 verify | caspase-7 → R10
2026-05-05 verify | nlrp3-inflammasome → R10
2026-05-04 verify | atg3 → R10
2026-05-04 ingest | round-10c-machinery-tissues → R10
2026-05-04 verify | xiap → R10
2026-05-04 verify | tbk1 → R10
2026-05-04 verify | ubiquitin-proteasome-system → R10
2026-05-04 verify | bcl-w → R10
2026-05-04 verify | atg10 → R10
2026-05-04 verify | grb2 → R10
2026-05-04 verify | 14-3-3 family page → R10
2026-05-04 ingest | round-10b-tier-a-entities → R10
2026-05-04 verify | dysbiosis hallmark synthesis-MOC → R10
2026-05-04 verify | chronic-inflammation synthesis-MOC → R10
2026-05-04 verify | stem-cell-exhaustion synthesis-MOC → R10
2026-05-04 verify | telomere-attrition synthesis-MOC → R10
2026-05-04 verify | deregulated-nutrient-sensing synthesis-MOC → R10
2026-05-04 verify | disabled-macroautophagy synthesis-MOC → R10
2026-05-04 verify | loss-of-proteostasis synthesis-MOC → R10
2026-05-04 verify | genomic-instability synthesis-MOC → R10
2026-05-04 ingest | round-10a-2 | dysbiosis → R10
2026-05-04 ingest | round-10a-2 | altered-intercellular-communication → R10
2026-05-04 ingest | round-10a-2 | chronic-inflammation → R10
2026-05-04 ingest | round-10a-2 | cellular-senescence → R10
2026-05-04 ingest | round-10a-2 | stem-cell-exhaustion → R10
2026-05-04 ingest | round-10a-hallmark-mocs | telomere-attrition → R10
2026-05-04 ingest | round-10a-hallmark-mocs | deregulated-nutrient-sensing → R10
2026-05-04 ingest | round-10a-hallmark-mocs → R10
2026-05-04 verify | negligible-senescence → R9
2026-05-04 verify | hyperfunction-theory → R9
2026-05-04 verify | free-radical-theory-of-aging → R9
2026-05-04 verify | disposable-soma-theory → R9
2026-05-04 ingest | round-9-hypotheses | disposable-soma-theory → R9
2026-05-04 ingest | round-9-hypotheses | negligible-senescence → R9
2026-05-04 ingest | round-9-hypotheses | information-theory-of-aging → R9
2026-05-04 ingest | round-9-hypotheses → R9
2026-05-04 verify | cancer.md → R8
2026-05-04 verify | frailty.md → R8
2026-05-04 verify | cardiac-fibrosis.md → R8
2026-05-04 verify | anemia-of-aging.md → R8
2026-05-04 verify | alzheimers-disease.md → R8
2026-05-04 verify | heart-failure.md → R8
2026-05-04 verify | neurodegeneration.md → R8
2026-05-04 verify | parkinsons-disease.md → R8
2026-05-04 ingest | round-8c-composite-cancer → R8
2026-05-04 ingest | round-8c-composite-frailty → R8
2026-05-04 ingest | round-8b-cardiovascular → R8
2026-05-04 ingest | round-8a-disease-entities → R8
2026-05-04 verify | growth-hormone → R8
2026-05-04 verify | daf-2 → R8
2026-05-04 verify | foxo4 protein page → R8
2026-05-05 verify | foxo-transcription-factors → R8
2026-05-04 verify | irs2 → R8
2026-05-04 verify | sgk1 → R8
2026-05-04 ingest | round-8b-cardiovascular → R8
2026-05-04 verify | bcl2l13 → R7
2026-05-04 verify | atg13 → R7
2026-05-04 verify | xenophagy → R7
2026-05-04 verify | atg101 → R7
2026-05-04 ingest | round-7d-followup → R7
2026-05-04 ingest | round-6e-followup → R6
2026-05-04 verify | molecules/proteins/foxo1.md → R7
2026-05-04 verify | molecules/proteins/insulin.md → R7
2026-05-04 verify | molecules/proteins/pdk1.md → R7
2026-05-04 verify | molecules/proteins/foxo3.md → R7
2026-05-04 verify | molecules/proteins/daf-16.md → R7
2026-05-04 verify | molecules/proteins/insr.md → R7
2026-05-04 verify | akt.md → R7
2026-05-04 verify | molecules/proteins/pi3k.md → R7
2026-05-04 ingest | round-7c-irs-foxo → R7
2026-05-04 ingest | round-7b-iis-receptors-ligands → R7
2026-05-04 ingest | round-7a-pi3k-akt-kinases → R7
2026-05-04 verify | chaperone-mediated-autophagy → R10
2026-05-04 ingest | round-10d | tau → R10
2026-05-04 verify | fundc1 → R6
2026-05-04 verify | spermidine → R6
2026-05-04 verify | lipophagy → R6
2026-05-04 verify | bnip3 → R6
2026-05-04 verify | atg5 → R6
2026-05-04 verify | pink1-parkin-pathway → R6
2026-05-04 verify | p62 → R6
2026-05-04 verify | pink1 → R6
2026-05-04 verify | parkin → R6
2026-05-04 verify | lc3 → R6
2026-05-04 verify | atg7 → R6
2026-05-04 ingest | round-6d-spermidine-atg-conjugation → R6
2026-05-04 ingest | round-6b-pink1-parkin-p62 → R6
2026-05-04 ingest | round-6a-core-autophagy → R6
2026-05-04 verify | processes/apoptosis.md → R5
2026-05-04 verify | molecules/compounds/a1331852.md → R5
2026-05-04 verify | molecules/proteins/caspase-8.md → R5
2026-05-04 verify | molecules/proteins/caspase-9.md → R5
2026-05-04 verify | molecules/proteins/bim.md → R5
2026-05-04 verify | molecules/compounds/navitoclax.md → R5
2026-05-04 verify | molecules/proteins/noxa.md → R5
2026-05-04 verify | molecules/proteins/bad.md → R5
2026-05-04 verify | molecules/proteins/cytochrome-c → R5
2026-05-04 verify | molecules/proteins/apaf-1 → R5
2026-05-04 ingest | round-5d-bcl2-family-signaling → R5
2026-05-04 verify | cell-types/hematopoietic-stem-cells.md → R3
2026-05-04 verify | cell-types/satellite-cells.md → R3
2026-05-04 verify | model-organisms/heterocephalus-glaber.md → R3
2026-05-04 verify | model-organisms/nothobranchius-furzeri.md → R3
2026-05-04 verify | model-organisms/saccharomyces-cerevisiae.md → R3
2026-05-04 verify | model-organisms/rattus-norvegicus.md → R3
2026-05-04 verify | model-organisms/homo-sapiens.md → R3
2026-05-04 verify | model-organisms/mus-musculus.md → R3
2026-05-04 verify | molecules/proteins/bid.md → R3
2026-05-04 verify | pathways/pi3k-akt-pathway.md → R3
2026-05-04 verify | molecules/proteins/rictor.md → R3
2026-05-04 verify | molecules/proteins/sirt1.md → R3
2026-05-04 verify | molecules/proteins/s6k1.md → R3
2026-05-04 verify | pathways/nf-kb.md → R3
2026-05-04 verify | interventions/pharmacological/senolytics.md → R3
2026-05-04 verify | molecules/compounds/nr.md → R3
2026-05-04 verify | molecules/compounds/metformin.md → R3
2026-05-04 verify | molecules/proteins/bax.md → R3
2026-05-04 verify | molecules/proteins/bcl-2.md → R3
2026-05-04 verify | pathways/sirtuin.md → R3
2026-05-04 verify | rapamycin compound page → R3
2026-05-04 verify | pathways/apoptosis-pathway.md → R3
2026-05-04 verify | p21 (CDKN1A) → R3
2026-05-04 seed+verify | Round 3b — Bcl-2 family proteins (4 of 4 drafted + verified) → R3
2026-05-04 verify | molecules/proteins/ulk1.md → R3
2026-05-04 seed | Round 3a — senolytics category page (first category-page prototype) → R3
2026-05-04 verify | molecules/proteins/puma.md → R2
2026-05-04 verify | Round 2 verification COMPLETE — 8 of 8 pages verified → R2
2026-05-04 seed | Round 2 COMPLETE — 8 of 8 entities drafted → R2
2026-05-04 seed | Round 2 dispatched — 8 seeders in parallel background → R2
2026-05-04 verify | molecules/compounds/dasatinib.md → R1
2026-05-04 verify | Round 1 COMPLETE — 12 of 12 pages verified (summary) → R1
2026-05-04 verify | pathways/insulin-igf1.md → R1
2026-05-04 verify | pathways/ampk.md → R1
2026-05-04 verify | wiki-verifier subagent confirmed working; Round 1 verification batch dispatched → R1
2026-05-04 verify | molecules/proteins/mdm2.md → R1
2026-05-04 verify | pathways/dna-damage-response.md → R1
2026-05-04 verify | pathways/mtor.md → R1
2026-05-04 verify | processes/autophagy.md → R1
2026-05-04 policy | archive search deprioritized; web-based citation discovery → R1
2026-05-04 seed | Round 1 COMPLETE — 12 of 12 entities drafted → R1
2026-05-04 verify | interventions/lifestyle/caloric-restriction.md → R1
2026-05-04 seed | Round 1 batch 2 — first parallel seeder run + caloric-restriction prototype → R1
2026-05-04 verify | phenotypes/immunosenescence.md → R1
2026-05-04 seed | Round 1 main-thread exemplars + wiki-seeder definition → R1
2026-05-04 verify | López-Otín 2023 hallmarks paper (PDF acquired via user manual download) → R4
2026-05-04 add | ROADMAP.md coverage tracker → R4
2026-05-04 add | wiki-verifier subagent → R4
2026-05-04 verify | first verification pass against PDFs → R4
2026-05-04 worked-examples + hallmark stubs → R4
2026-05-04 update | a local paper archive integration upgraded → R4
2026-05-04 seed | ampk (wiki-seeder subagent) → R4
2026-05-04 seed | p53-pathway (wiki-seeder subagent) → R4
2026-05-04 init | scaffold → R4
2026-05-04 verify | processes/sasp.md → R4
2026-05-04 verify | molecules/proteins/atm.md → R4
2026-05-04 verify | phenotypes/sarcopenia.md → R4
2026-05-04 verify | pathways/p53-pathway.md → R4
2026-05-04 verify | processes/mitophagy.md → R4
2026-05-04 verify | molecules/compounds/quercetin.md → R4
2026-05-04 verify | molecules/proteins/bcl-xl.md → R4
2026-05-04 verify | molecules/proteins/raptor.md → R4
2026-05-04 verify | molecules/proteins/fkbp12.md → R4
2026-05-04 verify | molecules/proteins/4ebp1.md → R4
2026-05-04 verify | molecules/proteins/tsc1-tsc2.md → R4
2026-05-04 verify | molecules/compounds/nmn.md → R4
2026-05-04 verify | molecules/compounds/nmn.md → R4
2026-05-04 verify | molecules/compounds/urolithin-a.md → R4
2026-05-04 ingest | Li 2023 — dual mTOR/NAD+ gerotherapy (bioRxiv preprint) → R4
2026-05-04 verify | molecules/proteins/bak.md → R4
2026-05-04 verify | molecules/proteins/mcl-1.md → R4
2026-05-04 verify | interventions/pharmacological/senomorphics.md → R4
2026-05-04 verify | model-organisms/drosophila-melanogaster.md → R4
2026-05-04 verify | model-organisms/caenorhabditis-elegans.md → R4
2026-05-04 verify | cell-types/cardiomyocytes.md → R4
2026-05-04 verify | cell-types/microglia.md → R4
2026-05-04 round-4 summary → R4
2026-05-04 lint — implicit-stub queue refresh → lint
2026-05-04 ingest | round-5a-bh3-only → R5
2026-05-04 ingest | round-5b-senolytics-apoptosome → R5
2026-05-04 ingest | round-5c-executioners-apoptosis-process → R5
2026-05-04 verify | molecules/proteins/caspase-3.md → R5
2026-05-04 verify | pathways/bcl-2-family-signaling.md → R5
2026-05-04 round-5 summary → R5
2026-05-04 ingest | round-6a-core-autophagy → R6
2026-05-04 ingest | round-6c-variants-receptors → R6
2026-05-04 ingest | round-6c-variants-receptors → R6
2026-05-04 ingest | round-6d-spermidine-atg-conjugation → R6
2026-05-04 ingest | round-6c-variants-receptors → R6
2026-05-04 verify | molecules/proteins/beclin-1.md → R6
2026-05-04 verify | tfeb → R6
2026-05-04 verify | atg12 → R6
2026-05-04 round-6 summary → R6
2026-05-04 ingest | round-7a-pi3k-akt-kinases → R7
2026-05-04 ingest | round-7b-iis-receptors-ligands → R7
2026-05-04 ingest | round-7c-irs-foxo → R7
2026-05-05 verify | pten → R7
2026-05-04 verify | molecules/proteins/irs-1.md → R7
2026-05-04 verify | molecules/proteins/igf1r.md → R7
2026-05-04 verify | molecules/proteins/igf-1.md → R7
2026-05-04 round-7 summary → R7
2026-05-04 ingest | round-6e-followup → R6
2026-05-04 ingest | round-6e-followup → R6
2026-05-04 ingest | round-7d-followup → R7
2026-05-04 ingest | round-7d-followup → R7
2026-05-04 verify | optn → R6
2026-05-04 verify | nix → R6
2026-05-04 verify | ndp52 → R6
2026-05-04 round-6e + round-7d follow-up summary → R6
2026-05-04 round-6e + round-7d follow-up summary → R6
2026-05-04 ingest | round-8a-disease-entities → R8
2026-05-04 ingest | round-8a-disease-entities → R8
2026-05-04 verify | atherosclerosis.md → R8
2026-05-04 verify | phenotypes/type-2-diabetes.md → R8
2026-05-04 verify | cardiovascular-aging.md → R8
2026-05-04 round-8 summary → R8
2026-05-04 verify | hypotheses/information-theory-of-aging → R9
2026-05-04 round-9 summary → R9
2026-05-04 lint — full pass post-Round-9 → lint
2026-05-04 ingest | Round 10a — epigenetic-alterations hallmark synthesis-MOC → R10
2026-05-04 verify | hallmarks/mitochondrial-dysfunction → R10
2026-05-04 verify | hallmarks/epigenetic-alterations → R10
2026-05-04 verify | hallmarks/cellular-senescence → R10
2026-05-04 verify | hallmarks/altered-intercellular-communication → R10
2026-05-04 round-10a summary → R10
2026-05-04 ingest | round-10b-tier-a-entities → R10
2026-05-04 verify | tissues/brain + tissues/bone-marrow → R10
2026-05-04 ingest | round-10c-machinery-tissues → R10
2026-05-05 verify | glut4 → R10
2026-05-04 verify | age-1 (AGE-1 PI3K) → R10
2026-05-04 verify | mitofusins → R10
2026-05-04 ingest | alpha-synuclein (Round 10d) → R10
2026-05-04 verify | round-10d → R10
2026-05-04 verify | round-10d → R10
2026-05-04 verify | round-10d → R10
2026-05-04 verify | round-10d → R10
2026-05-05 verify | round-10d → R10
2026-05-04 propagate | round-10d-corrections → R10
2026-05-05 ingest | taurine compound page → R11
2026-05-04 update | taurine.md — Fig. 4A selective-framing critique → R11
2026-05-04 update | taurine.md — Sharma 2025 cancer/mTOR concern + Fernandez methodology → R11
2026-05-04 update | taurine.md — three additional papers (Tzang 2024 meta-analysis, Chouraki 2017 Framingham, Ito 2023 review) → R11
2026-05-05 update | taurine — mechanistic-theory section added → R11
2026-05-05 verify | progeria → R11
2026-05-05 verify | klf4 → R11
2026-05-05 Round 11 batch summary (compounds + Yamanaka factors + visible-aging phenotypes) → R11
2026-05-05 verify | cbp-p300 → R20
2026-05-05 verify | molecules/proteins/drp1.md → R20
2026-05-05 verify | pathways/mitochondrial-dynamics.md → R20
2026-05-05 verify — molecules/proteins/b2m.md → R20
2026-05-05 verify — molecules/proteins/klotho.md → R20
2026-05-05 verify | molecules/proteins/ccl11.md → R20
2026-05-05 verify — molecules/proteins/terc.md → R20
2026-05-05 verify — molecules/proteins/dna-pkcs.md → R20
2026-05-05 verify — pathways/non-homologous-end-joining.md → R20
2026-05-05 verify — pathways/mismatch-repair.md → R20
2026-05-05 verify — molecules/proteins/brca1.md → R20
2026-05-05 verify — molecules/proteins/ercc1.md → R20
2026-05-05 verify — molecules/proteins/ogg1.md → R20
2026-05-05 verify — pathways/base-excision-repair.md → R20
2026-05-05 verify — R20 batch (13 pathway/protein synthesis pages, lightweight sweep) → R20
2026-05-06 R23 — Cell-therapy interventions + sparse-sibling intervention-folder buildout → R23
2026-05-06 R24 — Atomic-backlog completion + R23 follow-on + schema cleanup → R24
2026-05-06 R25 — Atomic-content backlog (Tier A + Tier B; 18 pages) → R25
2026-05-06 verify — molecules/proteins/gpr109a.md → R25
2026-05-06 verify — molecules/proteins/il-1ra.md (R25 Tier B; partial PDF pass) → R25
2026-05-06 R25 verifier sweep (18 pages) → R25
2026-05-06 verify — molecules/compounds/coq10.md (pass 2) → R26
2026-05-06 R26 — Round 26 housekeeping (started) → R26
2026-05-06 verify | hypotheses/antagonistic-pleiotropy.md → R24
2026-05-06 verify | molecules/proteins/tet1.md → R24
2026-05-06 verify | molecules/proteins/tet3.md → R24
2026-05-06 verify | cell-types/oligodendrocytes.md → R24
2026-05-06 R26b — R24 atomic-page verification sweep (DONE; 17/17 pages) → R24
2026-05-06 verify | cell-types/induced-pluripotent-stem-cells.md → R23
2026-05-06 verify | interventions/stem-cell-therapy/mesenchymal-stem-cell-therapy.md → R23
2026-05-06 verify | cell-types/mesenchymal-stem-cells.md → R23
2026-05-06 verify | cell-types/neural-stem-cells.md → R23
2026-05-06 verify | studies/li-2023-dual-mtor-nad-gerotherapy.md → R23
2026-05-06 verify | interventions/pharmacological/sirtuin-activators.md → R23
2026-05-06 verify | interventions/pharmacological/mtor-inhibitors.md → R23
2026-05-06 verify | interventions/lifestyle/sleep.md → R23
2026-05-06 verify | interventions/lifestyle/intermittent-fasting.md → R23
2026-05-06 verify | interventions/lifestyle/ketogenic-diet.md → R23
2026-05-06 R26c — R23 atomic-page verification sweep (DONE; 22/22 pages) → R23
2026-05-06 R26 — Round 26 close → R26
2026-05-07 R27 propagation pass → R27
2026-05-07 verify | irak4 → R28
2026-05-07 R28 propagation pass → R28
2026-05-07 verify | pathways/telomerase-pathway.md → R33
2026-05-07 verify | molecules/proteins/trf1.md → R33
2026-05-07 verify — studies/horvath-2013-epigenetic-clock.md → R33
2026-05-07 verify — processes/dna-methylation → R33
2026-05-07 verify — processes/dna-demethylation → R33
2026-05-07 verify — molecules/proteins/mutyh.md → R33
2026-05-07 verify — microbiome/lactobacillus.md → R33
2026-05-07 propagation R33 batch 1 → R33
2026-05-07 propagation R33 batch 2 → R33
2026-05-07 R33 close — Dysbiosis + altered-intercellular-communication → R33
2026-05-08 propagation | tier-1 aging-context rationale (R34 backlog) → R34
2026-05-08 recency+propagation | metformin (R34 backfill + R26c clearance) → recency
2026-05-08 recency | caloric-restriction (R34 backfill batch 1) → recency
2026-05-08 recency+propagation | NAD-precursor cluster (R34 backfill + R26c clearance) → recency
2026-05-08 lint | UniProt drift sweep (R34 backfill) → lint
2026-05-08 recency | canakinumab (R34 backfill batch 2) → recency
2026-05-08 recency | urolithin-A + spermidine (R34 backfill batch 2) → recency
2026-05-08 recency | BCL-xL senolytics + class page (R34 backfill batch 2) → recency
2026-05-08 recency | reprogramming + AAV gene therapy (R34 backfill batch 2) → recency
2026-05-08 recency | pharmacological class pages (R34 backfill batch 3) → recency
2026-05-08 recency | stem-cell + gene-therapy + plasma-exchange (R34 backfill batch 3) → recency
2026-05-08 recency | lifestyle cluster (R34 backfill batch 3) → recency
2026-05-08 recency | biomarker cluster (R34 backfill batch 3) → recency
2026-05-08 recency | hypothesis cluster (R34 backfill batch 3) → recency
2026-05-08 recency | GLP-1 + niche compounds (R34 backfill batch 4) → recency
2026-05-08 recency | mitochondrial + CR-mimetic compounds (R34 backfill batch 4) → recency
2026-05-08 ingest | Qi 2026 DHM-skin-aging epigenetic-clock paper (user-requested ad-hoc) → R35
2026-05-09 verify — molecules/proteins/tmsb4x.md → R35
2026-05-09 verify — biomarkers/gdf-15-biomarker.md → R35
2026-05-09 verify — molecules/proteins/nefl.md → R35
2026-05-09 verify — interventions/dietary/mediterranean-diet.md → R35
2026-05-09 verify — tocilizumab.md → R35
2026-05-09 verify — molecules/proteins/hmgcr.md → R35
2026-05-09 update — molecules/compounds/taurine.md (R35 user-supplied additions) → R35
2026-05-09 ingest | engineered-negligible-senescence batch (5 pages) → R40
2026-05-09 ingest | SENS-research current-state batch (8 pages + MOC update) → R40
2026-05-12 ingest | Zhang et al. 2023 Nature — naked-mole-rat HAS2 transgenic mice (xenogeneic gene transfer) → R40
2026-05-15 ingest | Trętowicz 2026 Nat Metab — whole-blood NAD+ stable with age → R40
2026-05-19 verify | molecules/proteins/mmp-3.md (R40) → R40
2026-05-19 verify | molecules/proteins/kitlg.md (R40) → R40
2026-05-19 verify — molecules/compounds/bakuchiol.md (R41 retinoid cluster) → R41
2026-05-29 ingest | Tyshkovskiy 2026 Nature — universal transcriptomic clocks (tAge) of mammalian ageing+mortality; 4 new pages + 7 propagated + R48 schema escalation → 2026-05-29
2026-06-04 ingest | androgen-deprivation-longevity hypothesis + 2 eunuch study pages (Min 2012, Hamilton-Mestler 1969); Garratt 2026/Sugrue 2021 evidence → 2026-06-04
2026-06-04 update | leydig-cells.md — § steroidogenesis-as-self-damage + reversibility (Chen-Zirkin 1999 full-text verified; Beattie 2013 abstract); limiting-factor mechanism → 2026-06-04
2026-06-04 ingest+update | testosterone MR (Ruth 2020 + Mohammadi-Shemirani 2020, full-text verified) + testosterone.md § MR + § mTOR-rate-of-aging directionality synthesis → 2026-06-04
2026-06-07 ingest | infectious hypothesis of AD + herpes-zoster-vaccine→dementia (YouTube-lead); alzheimers-disease.md § infectious-hypothesis/HZ-vaccination + § endogenous-lithium-depletion; neurodegeneration.md §6 latent-viral-reactivation → 2026-06-07
2026-06-09 ingest | thymic health (Bernatz/Aerts 2026 Nature companion papers) — deep-learning CT thymic-health score; 2 study pages + thymic-health-score biomarker; un-stubbed thymus; propagated to immunosenescence + disabled-adaptive-immunity + immune-system (closed-access, verified:false) → 2026-06-09
2026-06-12 verify | Farr 2024 D+Q bone RCT — schedule + design corrected (open-label, every-28d×5-cycles=20wk, dual-null SASP) across dasatinib/quercetin/senolytics/osteoporosis; resolved the sim D+Q-calibration dependency; corrected a P1NP category-error in the loop-note λ_infl anchor → 2026-06-12
2026-06-13 verify | Hickson 2019 D+Q senolytic — adipose/skin markers confirmed % positive cells (not mRNA), so the model kill-fraction is a legitimate per-cell kill; +86%→+8% progenitor digit-transposition fixed on dasatinib.md; skin added as 2nd-tissue anchor → 2026-06-13
2026-06-13 ingest | SenNet “senotype” senescence-heterogeneity Perspective (Suryadevara 2026 Cell) + 2 companion Krizhanovsky preprints (cross-organ senescence dynamics; csV1B2/ATP6V1B2 apoptosis-resistant subset); propagated to cellular-senescence + sasp + senolytics + new ATP6V1B2 stub → 2026-06-13
2026-06-13 ingest | 2 genuine SenNet companion DATA papers — SenCat (Anerillas 2026 Molecular Cell: 14 primary cell types × >30 paradigms, no universal senescence marker, ML signature) + spatial immunosenescence atlas (Farzad 2026, lymph-node germinal-center B-cell alteration, title-only); propagated to cellular-senescence + immunosenescence → 2026-06-13
2026-06-13 ingest | SenNet detection consensus (Suryadevara 2024 Nat Rev Mol Cell Biol “recommendations for detecting senescent cells in different tissues” — was missing) + saved the SenNet biomarker resource as sources/sennet-biomarkers.csv (703 curated marker entries × 11 cols, 14 tissues); propagated to cellular-senescence § Definition → 2026-06-13
2026-06-13 ingest | autonomic / cholinergic anti-inflammatory axis — 3 new pages seeded+verified (heart-rate-variability-biomarker, cholinergic-anti-inflammatory-pathway, chrna7/α7nAChR) from canonical primary literature (Errico npj-Aging-2025 perspective assessed + deliberately not cited per user — COI-heavy, no new data); verifier caught a Geurts-2023 MR sign-inversion + 6 other corrections; propagated to 9 pages → 2026-06-13
2026-06-14 ingest | autonomic/neuroendocrine axis round 2 — 4 new pages seeded+verified (tissues/vagus-nerve, molecules/metabolites/acetylcholine, molecules/metabolites/catecholamines [+β-adrenergic], pathways/hpa-axis [cortisol folded in]) from canonical primary literature; verifier caught a wrong Parkkinen-2008 DOI + a wrong (serotonin) TH citation + 2 transposed PMIDs + Braak 30–40%→17% + 22 relative-path links; propagated to ~20 pages → 2026-06-14
2026-06-14 ingest | vitamin D (cholecalciferol) + D3-K2 calcium-partitioning hypothesis — Phase 0 wiki content for a planned viz/ D3+K2 simulator intervention (design note model/vitamin-d3-k2-intervention-design.md, Codex-reviewed); seeded+verified molecules/compounds/vitamin-d (documents the VITAL/D-Health/ViDA hard-endpoint NULLs; verifier caught an 8.5× D-Health n error + a fabricated mortality HR) + hypotheses/d3-k2-calcium-partitioning (status:contested; AVADEC combined-arm null) + osteocalcin stub; propagated to 5 pages → 2026-06-14
2026-06-14 ingest | autonomic/neuroendocrine round 3 — 9 link-target pages seeded+verified: HPA-receptor cluster (nr3c1/GR, nr3c2/MR, combined hsd11b1-hsd11b2, crh) + catecholamine-enzyme cluster (grk2, tyrosine-hydroxylase, comt, combined monoamine-oxidase, cell-types/schwann-cells); aging-context tiers (MR/COMT/MAO=1, GR/GRK2/HSD=2, TH/CRH=3); verifier reversed a wrong 11β-HSD β-CTX result + caught EPHESUS HR/RR + FIGARO n + a fabricated GR fold-change; MAO verifier also fixed the catecholamines MAOA→MAOB ref; propagated to ~18 pages → 2026-06-14
2026-06-14 ingest | vitamin-K vascular evidence (Physionic YouTube reference-scrape; video non-citable per SOP) — 2 study pages seeded+verified (studies/shea-2009-vitamin-k-cac ITT-null K1 CAC trial that dominates the Li-2023 meta; studies/braam-2004-vitamin-dk-vessel-elasticity combined D+K1 elasticity RCT, closed-access) + Bellinge 2021/Asemi 2016 footnotes; propagated to the D3-K2 hypothesis + vascular-calcification + vitamin-k2 pages (incl. K1-vs-K2 diet-marker nuance); fixed a pre-existing Vlasschaert-2020 mis-attribution (was “Vermeer”) → 2026-06-14
2026-06-14 ingest | iron-regulatory axis — 3 protein pages seeded+verified (molecules/proteins/hepcidin [HAMP master regulator], molecules/proteins/ferroportin [SLC40A1 exporter + hepcidin receptor], molecules/proteins/fth1 [ferritin heavy chain / ferroxidase]) closing the iron-cluster dangling links; verifiers caught a fabricated Nemeth-2004 30→7.5-fold, an inverted Dugan-2026 CR result, a fabricated Sangkhae ERFE-placenta mechanism, 4 wrong ferroportin residues, a wrong Theil-2011 DOI, TET2→TET3; main agent fixed the Arezes ERFE-BMP6 citation (→2018 Blood); propagated to ferritin/ftl1/anemia-of-aging/ferroptosis/il-6/HSC → 2026-06-14
2026-06-14 ingest | Kattamis 2025 vamifeport β-NTDT Phase 2a study page (studies/kattamis-2025-vamifeport-ntdt) — ferroportin-inhibitor clinical proof-of-concept (n=25, on-target 2h iron restriction, clean safety; NOT an aging trial); verifier fixed sites 17→~20, discontinuations 1→2, MCV p-value to BID-only, flagged supplemental-derived Week-12 means; propagated to ferroportin → 2026-06-14
2026-06-24 ingest | Raz et al. 2026 Nat Aging — Saturating Removal damage-accumulation model + ballistic vs quasi-steady-state aging regimes; new studies/raz-2026-sr-model-aging-regimes + Mode-B hypotheses/saturating-removal-model (fills a missing mortality-dynamics frame); η = best lifespan predictor (7 orders of magnitude); propagated to _extrapolation-guide (mice=ballistic, dogs/cats/guinea-pigs human-like) + cellular-senescence + negligible-senescence; single-agent full-PDF extraction, verified:false (paper not yet in archive/PMC for independent pass) → 2026-06-24
2026-06-25 ingest | Xu 2015 eLife senescence→adipogenesis paper (studies/xu-2015-senescent-cells-adipogenesis, verified) — senescent fat progenitors secrete activin A → paracrine adipogenesis block; INK-ATTAC clearance + ruxolitinib reverse it (companion to, distinct from, the existing Xu 2015 PNAS JAK/frailty paper); seeded the missing molecules/proteins/inhba (activin A) node closing ≥5 dangling refs (verifier caught a fabricated n=80 + a Prokopidis effect-direction error). Plus 2 human senescent-cell accumulation surveys answering “do we have direct human data?”: studies/idda-2020-senescent-markers-human-tissues (primary p16/p21 IHC, 10 organs × 3 age groups) + studies/tuttle-2021-human-senescence-systematic-review (103 studies); propagated to sasp + a new human-accumulation paragraph on cellular-senescence + myostatin/aav-follistatin → 2026-06-25
2026-06-25 ingest | foundational p16 anchors + adipose pages (follow-on) — seeded studies/krishnamurthy-2004-ink4a-arf-aging-biomarker (verified; canonical rodent p16-as-aging-biomarker) + studies/ressler-2006-p16-human-skin-biomarker (closed-access, gap/no-fulltext-access) + tissues/white-adipose-tissue (verified; endocrine-system) + processes/adipogenesis (verified; PPARγ/C-EBP cascade + activin-A aging decline). Caught + fixed three second-hand-DOI errors (Ressler →.00231.x; Zaragosi sea-urchin DOI →10.2337/db10-0013; Tchkonia non-resolving →10.1111/j.1474-9726.2010.00608.x); verifiers fixed Rosen-2002 PPARγ-sufficiency mechanism + an Idda-2020 adipose misattribution; propagated to cellular-senescence/p16-rb-pathway/inhba/obesity/type-2-diabetes → 2026-06-25
2026-06-25 ingest | Physionic VERVE-102 video reference-mining — VERVE-102/Vafai-2026 centerpiece already covered; the video’s reference list surfaced the primary source for the wiki-wide “~3× lifetime-LDL benefit” claim (was sourced to a closed-access 2024 review / miscited to Cohen 2006). Seeded studies/ference-2012-ldl-mr-lifetime (JACC MR meta-analysis; 54.5% CHD reduction per mmol/L, n=312,321) + studies/ibanez-2021-pesa-subclinical-atherosclerosis (PESA imaging cohort; subclinical plaque in 49.7% of risk-factor-free adults). Re-anchored apob/ldlr/crispr-base-editing-pcsk9 to the primary + added a subclinical-onset paragraph to atherosclerosis; both new pages closed-access (#gap/no-fulltext-access, abstract-confirmed) → 2026-06-25
2026-06-28 ingest | vascular & lymphatic control of bone aging/regeneration (Kusumbe-lab YouTube interview; video non-citable per SOP, description had no refs → mapped transcript to lab primaries). 7 pages seeded+verified end-to-end: 4 study pages (studies/kusumbe-2014-type-h-vessels, studies/ramasamy-2014-endothelial-notch-bone, studies/kusumbe-2016-vascular-niche-aging, studies/biswas-2023-bone-lymphatics) + the contested studies/koh-2024-skull-marrow-reservoir (skull aging-resilience disputed; cited a 2025 multi-lab preprint as preprint-flagged supersession candidate, no video cited for rebuttal) + 2 lymphatic-marker proteins (molecules/proteins/prox1, molecules/proteins/lyve1 — first lymphatic coverage in the wiki). Verifiers caught a fabricated “Ramasamy 2016” paper, a p27→p21 source-typo propagation, and several n/p corrections. Propagated to bone/bone-marrow (new vascular-lymphatic-niche-decline sections), osteoblasts (fixed aged-cohort 57→64–70 wk + DFM 6-wk), cxcl12 (lymphatic-EC CXCL12 source), endothelial-cells (organ-specialized bone/lymphatic EC aging) → 2026-06-28
2026-07-21 ingest | Efimov et al. 2026 npj Aging — somatic-mutation-only human lifespan-bound model; seeded + independently verified study page, then propagated to somatic-mutation theory/process and genomic-instability navigation; headline outputs retained as conditional simulations, not observed lifespans → 2026-07-21
2026-08-02 ingest | Lombardo et al. 2026 PNAS — D+Q oligodendrocyte dysfunction/corpus-callosum demyelination safety signal; main article seeded + independently verified, then propagated to oligodendrocytes, senolytics, component compounds, cellular senescence, and UPR; retained as regimen-specific off-target evidence, not a senolysis/class effect → 2026-08-02
2026-08-02 ingest | Oppezzo et al. 2026 Nature Aging — tASO suppression of persistent telomeric DDR without telomere elongation; study + intervention independently verified, then propagated to telomere attrition, DDR, HSC/stem-cell exhaustion, TERC, and intervention/causal overlays; anti-TeloG-only repopulation rescue and two-donor ex-vivo human limit retained → 2026-08-02
2026-08-04 ingest+verify | omega-3 fatty-acid evidence audit — separated whole fish, nutritional EPA+DHA, purified prescription EPA and ALA; corrected the body-temperature oxidation, 1930s-essentiality, endogenous-omega and Inuit-CVD inference chain; retained the high-dose atrial-fibrillation signal and formulation/population-specific outcome heterogeneity → 2026-08-04
2026-08-10 ingest | omega-3 × skeletal muscle (Physionic YouTube reference-scrape; video non-citable per SOP) — closed a real gap: the verified omega-3 page had no muscle coverage and sarcopenia had no omega-3 coverage. 5 study pages seeded (3 verified against PMC full text). Corrected the transcript’s mechanistic claims against primary sources (MPS enhanced only under amino-acid/insulin stimulation, basal unchanged; “mitochondrial membrane doesn’t change” applies only to bulk phospholipid abundance, not fatty-acid composition, where the sarcolemma is least responsive; Herbst’s raised ROS-emission capacity came with no rise in measured oxidative damage). Adversarial Codex review (gpt-5.6-sol xhigh) then caught two errors in my own synthesis, both confirmed against primary full text: Therdyothin’s headline MPS null pooled basal FSR — the estimand where Smith also found nothing — so the sensitization hypothesis is unconfirmed rather than refuted (stimulated-state pools ns but wide: SMD 0.41 k=3, 0.52 k=4); and “no mass effect in any major synthesis” was false (Huang 2020: +0.33 kg, +0.67 kg above 2 g/day). Section rewritten less negative and better calibrated → 2026-08-10

🧬 Aging Wiki

Explorer

log

aging_wiki — chronological log

Graph View

Backlinks