Hematopoietic System

Navigational overlay for blood-cell production and the bone-marrow niche. Hematopoietic aging is one of the best-characterized stem-cell-aging systems: HSCs accumulate DNA damage and epigenetic drift, skew toward myeloid output, and give rise to clonal expansions (CHIP) that carry inflammatory and cardiovascular risk. It overlaps heavily with the immune-system (which it supplies) and connects to the musculoskeletal-system through the shared marrow niche.

Tissues & organs

• bone-marrow — the hematopoietic niche; marrow adiposity rises with age

Cell types

• hematopoietic-stem-cells — myeloid-biased, less self-renewing, clonally restricted with age
• mesenchymal-stem-cells — stromal niche support (BM-MSCs); fate-drift remodels the niche

Aging phenotypes

• anemia-of-aging — unexplained anemia of the elderly
• clonal-hematopoiesis — CHIP; age-acquired driver-mutation clones
• immunosenescence — downstream of myeloid-biased, lymphoid-poor output (shared with immune-system)

Key molecular axes

• CHIP drivers: sf3b1, DNMT3A, TET2, JAK2 (see clonal-hematopoiesis)
• Inflammatory coupling: il-6, chronic-inflammation

Auto-aggregated tissue members

LIST FROM "tissues"
WHERE parent-system = "hematopoietic-system"
SORT file.name

Missing / planned pages

• [[blood]], [[spleen]], [[erythrocytes]], [[platelets]], [[megakaryocytes]], [[neutrophils]] — not yet seeded stub

See also

• by-organ-system — index of all body-system MOCs
• immune-system — supplied by hematopoiesis; shares HSCs and CHIP
• stem-cell-exhaustion — the defining hallmark for HSC aging