Immune System
Navigational overlay for innate and adaptive immunity, the lymphoid organs, and tissue-resident immune cells. Immune aging is bidirectional: declining protective immunity (immunosenescence) coexists with rising sterile inflammation (inflammaging), and the two are mechanistically linked through senescent-cell SASP, thymic involution, and myeloid-biased hematopoiesis. This overlay also subsumes the lymphatic system until it warrants its own MOC.
Tissues & organs
- bone-marrow — source of all immune cells (shared with hematopoietic-system)
Cell types
- hematopoietic-stem-cells — myeloid-biased output and clonal drift with age
- microglia — CNS-resident macrophages (shared with nervous-system)
- langerhans-cells — skin-resident dendritic cells (shared with integumentary-system)
Aging phenotypes
- immunosenescence — decline of adaptive immunity; impaired vaccine response, infection susceptibility
- clonal-hematopoiesis — age-acquired clonal expansions (CHIP); inflammatory and cardiovascular risk (overlap with hematopoietic-system)
Key molecular axes
- Inflammaging mediators: il-6, chronic-inflammation, the nlrp3-inflammasome / caspase-1 axis
- CHIP drivers: sf3b1, DNMT3A, TET2 (see clonal-hematopoiesis)
- Senescence-immune surveillance: senescence-immune-surveillance, senescence-escape
Auto-aggregated tissue members
LIST FROM "tissues"
WHERE parent-system = "immune-system" OR parent-system = "lymphatic-system"
SORT file.nameMissing / planned pages
- thymus (thymic involution — central to immunosenescence) and spleen — now seeded as stubs (need full content)
[[lymph-nodes]],[[lymphatic-vessels]],[[tonsils]]— lymphoid organs not yet seeded stub[[t-cells]],[[b-cells]],[[macrophages]],[[neutrophils]],[[nk-cells]],[[dendritic-cells]]— immune cell types not yet seeded stub
See also
- by-organ-system — index of all body-system MOCs
- hematopoietic-system — shares bone marrow, HSCs, and the CHIP phenotype
- disabled-adaptive-immunity · chronic-inflammation — the two immune-relevant hallmarks