Respiratory System

Navigational overlay for the lungs and airways. This system is currently a planned area of the wiki — no dedicated lung page exists yet. Lung aging is characterized by declining elastic recoil, enlarged airspaces (“senile emphysema”), impaired mucociliary clearance, and a strong cellular-senescence component: idiopathic pulmonary fibrosis (IPF) is one of the canonical senescence-driven age-related diseases, and the lung is a frequent target of senolytic and senomorphic research.

Key aging themes (pending dedicated pages)

• Cellular senescence: alveolar epithelial (AT2) and fibroblast senescence drive IPF — see cellular-senescence, senolytics
• Stem-cell exhaustion: decline of AT2 progenitor capacity
• Inflammaging: elevated lung inflammatory tone; overlap with immune-system (alveolar macrophages)

Auto-aggregated tissue members

LIST FROM "tissues"
WHERE parent-system = "respiratory-system"
SORT file.name

Missing / planned pages

• lung — now seeded as a stub (needs full content); the anchor page to flesh out
• [[alveoli]], [[bronchi]], [[diaphragm]], [[pleura]] — not yet seeded stub
• [[pulmonary-fibrosis]] / [[idiopathic-pulmonary-fibrosis]], [[copd]] — phenotypes not yet seeded stub
• [[alveolar-epithelial-cells]], [[alveolar-macrophages]] — cell types not yet seeded stub

See also

• by-organ-system — index of all body-system MOCs
• cellular-senescence — IPF is a flagship senescence-driven aging disease
• immune-system — alveolar macrophages and lung-resident immunity