⚠️ Auto-extracted by Claude on 2026-06-13 — abstract NOT available (closed-access Cell Press journal; not indexed in PubMed/Europe PMC at seeding). The content below is from the title and press coverage only — no abstract or full text was read. Treat as a citable record/stub, not a verified extraction; do NOT add claims beyond the title until the source is accessible. gap/no-fulltext-access gap/abstract-unavailable
Farzad et al. 2026 — spatial multi-omics atlas of immunosenescence (SenNet)
Cell Press Blue (Cell Press journal; DOI code cpblue — confirm exact journal name on verification), 2026, article 100053. doi:10.1016/j.cpblue.2026.100053. 33 authors; a NIH SenNet consortium data paper. First author Negin Farzad is also the second author of the companion SenNet Perspective suryadevara-2026-senotypes.
Access: Closed-access; abstract not retrievable at seeding. gap/no-fulltext-access gap/abstract-unavailable
What this paper is (title + press only)
A spatial multi-omics atlas of immunosenescence in human lymph nodes. Per the title, the headline finding is an alteration of germinal-center B cells with immunosenescence. This is one of the SenNet companion data papers that supply the tissue-level data behind the suryadevara-2026-senotypes senotype framework (the immune-system / lymphoid arm).
No further claims are recorded here pending an accessible abstract or full text — see the banner. A verification pass should capture: the tissues/cell types profiled, the spatial-omics modalities used, the specific germinal-center B-cell changes (and any senescence markers named), and any quantitative results.
Significance for the wiki (provisional)
Immunosenescence of the lymph node / germinal-center compartment is directly relevant to immunosenescence and to the broader theme that declining immune surveillance → reduced clearance of senescent cells → accumulation (see cellular-senescence § Developmental / transient senescence and senescence-immune-surveillance). Once verified, this atlas may strengthen those links with spatially-resolved human data.
Cross-references
- immunosenescence — primary phenotype home (lymphoid/immune aging)
- suryadevara-2026-senotypes — companion SenNet Perspective
- cellular-senescence — senotype framework