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69 items under this folder.
Jun 04, 2026
Loss of epigenetic information as a cause of mammalian aging
gap/needs-replication
gap/needs-human-replication
gap/unsourced
gap/long-term-unknown
Jun 04, 2026
A single-nucleus transcriptomic atlas of primate liver aging uncovers the pro-senescence role of SREBP2 in hepatocytes
Jun 04, 2026
Fisetin is a senotherapeutic that extends health and lifespan
Jun 04, 2026
Increased hyaluronan by naked mole-rat Has2 improves healthspan in mice
gap/contradictory-evidence
gap/needs-replication
gap/dose-response-unclear
gap/no-mechanism
gap/needs-human-replication
Jun 04, 2026
Nuclear cGAS restricts L1 retrotransposition by promoting TRIM41-mediated ORF2p ubiquitination and degradation
gap/needs-human-replication
gap/no-mechanism
gap/needs-replication
Jun 04, 2026
Berberine ameliorates atherosclerosis by inhibiting the phenotypic transition of vascular smooth muscle cells via suppression of the JAK2/STAT3 signaling pathway
gap/needs-pdf-fetch
gap/needs-replication
gap/no-mechanism
gap/dose-response-unclear
gap/needs-human-replication
Jun 04, 2026
Tretinoin (0.05% cream vs. 5% peel) for photoaging and field cancerization of the forearms: randomized, evaluator-blinded, clinical trial
gap/no-fulltext-access
gap/needs-replication
gap/dose-response-unclear
gap/long-term-unknown
Jun 04, 2026
Cardiovascular Outcomes with Tirzepatide versus Dulaglutide in Type 2 Diabetes
gap/no-fulltext-access
gap/contradictory-evidence
gap/needs-pdf-verification
gap/no-mechanism
gap/needs-replication
Jun 04, 2026
Berberine for preventing colorectal adenoma recurrence and neoplasm occurrence: 6-year follow-up of a randomized clinical trial
gap/no-mechanism
Jun 04, 2026
Human whole-blood NAD+ levels do not vary with age or lifestyle interventions
Jun 04, 2026
p53 mutant mice that display early ageing-associated phenotypes
gap/needs-human-replication
Jun 04, 2026
Universal transcriptomic hallmarks of mammalian ageing and mortality
gap/needs-human-replication
gap/no-mechanism
Jun 04, 2026
Mitochondrial oxidative stress caused by Sod2 deficiency promotes cellular senescence and aging phenotypes in the skin
gap/unsourced
gap/needs-human-replication
Jun 04, 2026
Effect of long-term caloric restriction on DNA methylation measures of biological aging in healthy adults from the CALERIE™ trial
gap/needs-replication
gap/long-term-unknown
Jun 04, 2026
Efficacy and safety of berberine for several cardiovascular diseases: a systematic review and meta-analysis of randomized controlled trials
gap/no-fulltext-access
gap/no-mechanism
gap/contradictory-evidence
gap/dose-response-unclear
Jun 04, 2026
Smad3-dependent regulation of type I collagen in human dermal fibroblasts: Impact on human skin connective tissue aging
gap/no-fulltext-access
gap/no-mechanism
gap/needs-replication
Jun 04, 2026
Epigenetic Skin Aging and Its Reversal to Improve Skin Longevity across Ethnicities and Phototypes Using a Dihydromyricetin-Containing Serum: Results from a Prospective, Single-Cohort Study
gap/no-mechanism
gap/needs-replication
Jun 04, 2026
Semaglutide ameliorates osteoarthritis progression through a weight loss-independent metabolic restoration mechanism
gap/needs-pdf-verification
gap/needs-replication
Jun 04, 2026
Targeting iron-associated protein Ftl1 in the brain of old mice improves age-related cognitive impairment
gap/needs-replication
gap/needs-human-replication
gap/no-mechanism
gap/needs-sex-stratification
gap/dose-response-unclear
gap/long-term-unknown
Jun 04, 2026
Non-invasive epidermis sampling for DNA methylation-based prediction of skin cancer phenotypes
gap/needs-human-replication
gap/needs-replication
gap/no-mechanism
gap/not-reported
Jun 04, 2026
Biological aging and lifespan in men and women using a Mendelian randomization study
gap/needs-replication
gap/contradictory-evidence
Jun 04, 2026
Propagation of senescent phenotypes by extracellular HMGB1 is dependent on its redox state
Jun 04, 2026
Inhibition of 15-hydroxy prostaglandin dehydrogenase promotes cartilage regeneration
gap/needs-replication
gap/no-mechanism
gap/long-term-unknown
gap/needs-human-replication
Jun 04, 2026
soengas-2001-apaf1-melanoma
Jun 04, 2026
Exercise and Weekly Sirolimus (Rapamycin) in Older Adults: RAPA-EX-01 Randomised, Double-Blind, Placebo-Controlled Trial
Jun 04, 2026
Ancestral protein reconstruction reveals the mechanism of substrate specificity in FN3K-mediated deglycation
gap/needs-peer-review
gap/needs-replication
Jun 04, 2026
Odanacatib for the treatment of postmenopausal osteoporosis: results of the LOFT multicentre, randomised, double-blind, placebo-controlled trial and LOFT Extension study
gap/no-mechanism
gap/no-fulltext-access
gap/needs-replication
Jun 04, 2026
Liraglutide, a glucagon-like peptide 1 receptor agonist, exerts analgesic, anti-inflammatory and anti-degradative actions in osteoarthritis
Jun 04, 2026
The Immunoglobulin G Glycome: A Modifiable Biomarker and Functional Effector of Aging, Disease, and Mortality
gap/needs-peer-review
gap/needs-replication
Jun 04, 2026
In Vivo Amelioration of Age-Associated Hallmarks by Partial Reprogramming
gap/needs-human-replication
gap/long-term-unknown
gap/needs-replication
gap/dose-response-unclear
gap/stub
Jun 04, 2026
Impact of polyphenol oxidase on the bioavailability of flavan-3-ols in fruit smoothies: a controlled, single blinded, cross-over study
gap/needs-replication
gap/long-term-unknown
gap/no-mechanism
Jun 04, 2026
Inhibition of prostaglandin-degrading enzyme 15-PGDH rejuvenates aged muscle mass and strength
gap/unsourced
gap/needs-replication
gap/dose-response-unclear
gap/needs-human-replication
gap/long-term-unknown
Jun 04, 2026
Systemic proteome adaptions to 7-day complete caloric restriction in humans
gap/contradictory-evidence
Jun 04, 2026
Role of fibroblast-derived growth factors in regulating hyperpigmentation of solar lentigo
gap/no-fulltext-access
gap/contradictory-evidence
Jun 04, 2026
The skin aging exposome
gap/needs-canonical-id
gap/needs-replication
gap/unsourced
gap/long-term-unknown
Jun 04, 2026
Berberine and adiposity in diabetes-free individuals with obesity and MASLD: a randomized clinical trial
gap/needs-replication
gap/contradictory-evidence
gap/dose-response-unclear
gap/long-term-unknown
Jun 04, 2026
A dual mTOR/NAD+ acting gerotherapy
gap/needs-human-replication
Jun 04, 2026
Ferulic Acid Stabilizes a Solution of Vitamins C and E and Doubles its Photoprotection of Skin
gap/no-mechanism
gap/needs-human-replication
gap/dose-response-unclear
stub
gap/long-term-unknown
gap/needs-replication
Jun 04, 2026
Nuclear cGAS suppresses DNA repair and promotes tumorigenesis
gap/no-fulltext-access
gap/no-mechanism
gap/needs-human-replication
Jun 04, 2026
The Hallmarks of Aging
Jun 04, 2026
Hallmarks of aging: An expanding universe
Jun 04, 2026
Reprogramming to recover youthful epigenetic information and restore vision
gap/needs-human-replication
gap/needs-replication
gap/stub
Jun 04, 2026
Berberine treats atherosclerosis via a vitamine-like effect down-regulating Choline-TMA-TMAO production pathway in gut microbiota
gap/needs-replication
gap/long-term-unknown
gap/needs-human-replication
Jun 04, 2026
Exceptional Longevity Modifying Allele APOE2 Promotes DNA Signaling Pathways Resisting Cellular Senescence in Human Neurons
Jun 04, 2026
The Epidermal Stem Cell Factor Is Over-Expressed in Lentigo Senilis: Implication for the Mechanism of Hyperpigmentation
gap/needs-replication
gap/needs-canonical-id
gap/contradictory-evidence
gap/no-mechanism
Jun 04, 2026
DNA methylation age of human tissues and cell types
gap/no-mechanism
gap/needs-replication
gap/unsourced
gap/contradictory-evidence
Jun 04, 2026
Sunscreen and prevention of skin aging: a randomized trial
gap/no-fulltext-access
gap/needs-replication
gap/long-term-unknown
Jun 04, 2026
Genotoxic stress abrogates renewal of melanocyte stem cells by triggering their differentiation
gap/needs-replication
gap/needs-human-replication
gap/no-mechanism
Jun 04, 2026
Discovery and characterization of antitumor gut microbiota from amphibians and reptiles: Ewingella americana as a novel therapeutic agent with dual cytotoxic and immunomodulatory properties
gap/needs-human-replication
gap/needs-supp-verification
gap/genome-not-sequenced
gap/no-mechanism
gap/needs-precedent-citation
gap/needs-replication
Jun 04, 2026
Super-adjuvant nanoparticles for platform cancer vaccination
gap/needs-human-replication
gap/needs-replication
Jun 04, 2026
Berberine is a novel cholesterol-lowering drug working through a unique mechanism distinct from statins
gap/no-fulltext-access
gap/no-mechanism
gap/needs-replication
Jun 04, 2026
README
Jun 04, 2026
Regeneration of neuromuscular synapses after acute and chronic denervation by inhibiting the gerozyme 15-prostaglandin dehydrogenase
gap/needs-human-replication
gap/needs-replication
gap/no-mechanism
gap/needs-verification
gap/long-term-unknown
gap/dose-response-unclear
Jun 04, 2026
Autoantibodies neutralizing type I IFNs are present in ~4% of uninfected individuals over 70 years old and account for ~20% of COVID-19 deaths
gap/needs-replication
gap/no-mechanism
gap/dose-response-unclear
gap/long-term-unknown
Jun 04, 2026
Increased skin autofluorescence predicts future cancer development
gap/no-mechanism
gap/needs-replication
gap/needs-human-replication
Jun 04, 2026
Reduced DNA methylation patterning and transcriptional connectivity define human skin aging
gap/needs-replication
gap/no-mechanism
Jun 04, 2026
Berberine versus placebo for the prevention of recurrence of colorectal adenoma: a multicentre, double-blinded, randomised controlled study
gap/no-fulltext-access
gap/unsourced
gap/needs-replication
gap/no-mechanism
gap/long-term-unknown
Jun 04, 2026
A cGAS-mediated mechanism in naked mole-rats potentiates DNA repair and delays aging
gap/no-fulltext-access
gap/no-mechanism
gap/needs-human-replication
gap/needs-replication
Jun 04, 2026
Test of Rapamycin in Aging Dogs (TRIAD): study design and rationale for a prospective, parallel-group, double-masked, randomized, placebo-controlled, multicenter trial of rapamycin in healthy middle-aged dogs from the Dog Aging Project
gap/needs-citation-verification
gap/long-term-unknown
gap/needs-nct-id-confirmation
stub
gap/no-disclosure
Jun 04, 2026
Prolonged fasting promotes systemic inflammation and platelet activation in humans: a medically supervised, water-only fasting and refeeding study
Jun 04, 2026
Modulation of circulating levels of advanced glycation end products and its impact on intima-media thickness of both common carotid arteries: CORDIOPREV randomised controlled trial
gap/needs-replication
gap/long-term-unknown
Jun 04, 2026
Semaglutide Slows Epigenetic Aging in People with HIV-associated lipohypertrophy: Evidence from a Randomized Controlled Trial
gap/needs-healthy-population-replication
gap/long-term-unknown
Jun 04, 2026
An open science study of ageing in companion dogs
gap/needs-replication
gap/long-term-unknown
gap/needs-citation-verification
Jun 04, 2026
Analysis of physiological and biochemical changes and metabolic shifts during 21-Day fasting hypometabolism
Jun 04, 2026
Enzymatic Deglycation of Damaged Skin by Means of Combined Treatment of Fructosamine-3-Kinase and Fructosyl-Amino Acid Oxidase
gap/needs-replication
gap/long-term-unknown
Jun 04, 2026
An Essential Role for Senescent Cells in Optimal Wound Healing through Secretion of PDGF-AA
gap/needs-replication
gap/needs-human-replication
Jun 04, 2026
Identification of dihydromyricetin as a natural DNA methylation inhibitor with rejuvenating activity in human skin
gap/no-mechanism
gap/needs-replication
gap/needs-human-replication
gap/long-term-unknown
Jun 04, 2026
Molecular basis of sun-induced premature skin ageing and retinoid antagonism
Jun 04, 2026
Collagen Fragmentation Promotes Oxidative Stress and Elevates Matrix Metalloproteinase-1 in Fibroblasts in Aged Human Skin
gap/unsourced
gap/needs-human-replication
gap/needs-replication
gap/no-mechanism