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159 items under this folder.
Aug 18, 2026
A single-nucleus transcriptomic atlas of primate liver aging uncovers the pro-senescence role of SREBP2 in hepatocytes
Aug 18, 2026
Tobacco smoking and somatic mutations in human bronchial epithelium
gap/intercept-not-reported
gap/dose-response-unclear
gap/no-mechanism
gap/needs-replication
gap/unsourced
Aug 18, 2026
Fisetin is a senotherapeutic that extends health and lifespan
Aug 18, 2026
Ruminococcus bromii is a keystone species for the degradation of resistant starch in the human colon
gap/needs-human-replication
Aug 18, 2026
Targeting Cancer-Specific Mutations with RNA-Triggered Chromatin Shredding
gap/no-mechanism
gap/long-term-unknown
gap/no-fulltext-access
Aug 18, 2026
Inhibitory effect of lanosterol on cataractous lens of cynomolgus monkeys using a subconjunctival drug release system
gap/needs-replication
gap/needs-human-replication
Aug 18, 2026
Increased hyaluronan by naked mole-rat Has2 improves healthspan in mice
gap/contradictory-evidence
gap/needs-replication
gap/dose-response-unclear
gap/no-mechanism
gap/needs-human-replication
Aug 18, 2026
Taurine Intake, Plasma Taurine Concentration, and Dementia Risk: Findings From the Malmƶ Diet and Cancer Study
Aug 18, 2026
Lanosterol reverses protein aggregation in cataracts
gap/needs-human-replication
gap/needs-replication
gap/needs-supp-verification
gap/contradictory-evidence
Aug 18, 2026
Nuclear cGAS restricts L1 retrotransposition by promoting TRIM41-mediated ORF2p ubiquitination and degradation
gap/needs-human-replication
gap/no-mechanism
gap/needs-replication
Aug 18, 2026
Berberine ameliorates atherosclerosis by inhibiting the phenotypic transition of vascular smooth muscle cells via suppression of the JAK2/STAT3 signaling pathway
gap/needs-pdf-fetch
gap/needs-replication
gap/no-mechanism
gap/dose-response-unclear
gap/needs-human-replication
Aug 18, 2026
Universal transcriptomic hallmarks of mammalian ageing and mortality
gap/needs-human-replication
gap/no-mechanism
Aug 18, 2026
In Vivo Base Editing of PCSK9 with VERVE-102 for Hypercholesterolemia
gap/long-term-unknown
gap/needs-human-replication
gap/needs-replication
gap/no-mechanism
Aug 18, 2026
Mitochondrial oxidative stress caused by Sod2 deficiency promotes cellular senescence and aging phenotypes in the skin
gap/unsourced
gap/needs-human-replication
Aug 18, 2026
Variable responses of human microbiomes to dietary supplementation with resistant starch
gap/needs-replication
Aug 18, 2026
Gut-microbiota-targeted diets modulate human immune status
gap/needs-replication
gap/long-term-unknown
Aug 18, 2026
Effect of long-term caloric restriction on DNA methylation measures of biological aging in healthy adults from the CALERIEā¢ trial
gap/needs-replication
gap/long-term-unknown
Aug 18, 2026
Inhibition of IL-11 signalling extends mammalian healthspan and lifespan
gap/needs-human-replication
gap/needs-replication
gap/dose-response-unclear
gap/long-term-unknown
Aug 18, 2026
Modulating IL-11-dependent matrix stiffness to delay ovarian aging
gap/needs-human-replication
gap/needs-replication
gap/long-term-unknown
gap/no-mechanism
gap/dose-response-unclear
Aug 18, 2026
Sleep Drives Metabolite Clearance from the Adult Brain
gap/source-discrepancy
gap/no-mechanism
gap/needs-human-replication
gap/needs-replication
Aug 18, 2026
Targeting senescent cells enhances adipogenesis and metabolic function in old age
gap/needs-human-replication
gap/dose-response-unclear
Aug 18, 2026
Efficacy and safety of berberine for several cardiovascular diseases: a systematic review and meta-analysis of randomized controlled trials
gap/no-fulltext-access
gap/no-mechanism
gap/contradictory-evidence
gap/dose-response-unclear
Aug 18, 2026
Loss of epigenetic information as a cause of mammalian aging
gap/needs-replication
gap/needs-human-replication
gap/unsourced
gap/long-term-unknown
Aug 18, 2026
Exercise and Weekly Sirolimus (Rapamycin) in Older Adults: RAPA-EX-01 Randomised, Double-Blind, Placebo-Controlled Trial
Aug 18, 2026
Tretinoin (0.05% cream vs. 5% peel) for photoaging and field cancerization of the forearms: randomized, evaluator-blinded, clinical trial
gap/no-fulltext-access
gap/needs-replication
gap/dose-response-unclear
gap/long-term-unknown
Aug 18, 2026
Cardiovascular Outcomes with Tirzepatide versus Dulaglutide in Type 2 Diabetes
gap/no-fulltext-access
gap/contradictory-evidence
gap/needs-pdf-verification
gap/no-mechanism
gap/needs-replication
Aug 18, 2026
SenNet recommendations for detecting senescent cells in different tissues
gap/no-fulltext-access
Aug 18, 2026
Charting human cellular senescence in aging and disease
gap/no-fulltext-access
Aug 18, 2026
Berberine for preventing colorectal adenoma recurrence and neoplasm occurrence: 6-year follow-up of a randomized clinical trial
gap/no-mechanism
Aug 18, 2026
RESULTS: FROM A RANDOMIZED CLINICAL TRIAL EVALUATING THE SENOLYTIC FISETIN FOR TREATING KNEE OSTEOARTHRITIS
gap/needs-full-paper-publication
gap/needs-replication
gap/no-mechanism
gap/dose-response-unclear
gap/needs-human-replication
stub
Aug 18, 2026
Disrupted glymphatic function and its relationship with sleep and cognitive impairment in ME/CFS assessed via DTI-ALPS
gap/no-mechanism
gap/needs-replication
Aug 18, 2026
The effects of omega-3 polyunsaturated fatty acids on muscle and whole-body protein synthesis: a systematic review and meta-analysis
gap/needs-replication
gap/long-term-unknown
Aug 18, 2026
Reversal of protein chemical aging by enzymatic deglycation
gap/needs-human-replication
gap/needs-replication
gap/long-term-unknown
Aug 18, 2026
Human whole-blood NAD+ levels do not vary with age or lifestyle interventions
Aug 18, 2026
Senescence in tissue samples of humans with age-related diseases: A systematic review
gap/no-fulltext-access
Aug 18, 2026
p53 mutant mice that display early ageing-associated phenotypes
gap/needs-human-replication
Aug 18, 2026
Non-invasive epidermis sampling for DNA methylation-based prediction of skin cancer phenotypes
gap/needs-human-replication
gap/needs-replication
gap/no-mechanism
gap/not-reported
Aug 18, 2026
Using human genetics to understand the disease impacts of testosterone in men and women
gap/no-narrative-or-stated
gap/contradictory-evidence
Aug 18, 2026
The Influence of n-3PUFA Supplementation on Muscle Strength, Mass, and Function: A Systematic Review and Meta-Analysis
gap/contradictory-evidence
Aug 18, 2026
IL-11 is a crucial determinant of cardiovascular fibrosis
gap/needs-human-replication
Aug 18, 2026
Biological aging and lifespan in men and women using a Mendelian randomization study
gap/needs-replication
gap/contradictory-evidence
Aug 18, 2026
Effect of lanosterol on human cataract nucleus
gap/contradictory-evidence
Aug 18, 2026
Taurine from tumour niche drives glycolysis to promote leukaemogenesis
gap/needs-human-replication
Aug 18, 2026
Vitamin K supplementation and progression of coronary artery calcium in older men and women
gap/no-mechanism
gap/needs-replication
gap/dose-response-unclear
Aug 18, 2026
Propagation of senescent phenotypes by extracellular HMGB1 is dependent on its redox state
Aug 18, 2026
Taurine deficiency as a driver of aging
gap/needs-human-replication
gap/needs-replication
Aug 18, 2026
Inhibition of 15-hydroxy prostaglandin dehydrogenase promotes cartilage regeneration
gap/needs-replication
gap/no-mechanism
gap/long-term-unknown
gap/needs-human-replication
Aug 18, 2026
Dietary omega-3 fatty acid supplementation increases the rate of muscle protein synthesis in older adults: a randomized controlled trial
gap/needs-replication
gap/no-mechanism
Aug 18, 2026
Fish oil-derived n-3 PUFA therapy increases muscle mass and function in healthy older adults
gap/contradictory-evidence
gap/needs-replication
gap/long-term-unknown
Aug 18, 2026
soengas-2001-apaf1-melanoma
Aug 18, 2026
Ocular delivery of lipid nanoparticles-formulated mRNA encoding lanosterol synthase ameliorates cataract in rats
gap/needs-human-replication
gap/needs-replication
gap/long-term-unknown
Aug 18, 2026
Impact of polyphenol oxidase on the bioavailability of flavan-3-ols in fruit smoothies: a controlled, single blinded, cross-over study
gap/needs-replication
gap/long-term-unknown
gap/no-mechanism
Aug 18, 2026
Inhibition of prostaglandin-degrading enzyme 15-PGDH rejuvenates aged muscle mass and strength
gap/unsourced
gap/needs-replication
gap/dose-response-unclear
gap/needs-human-replication
gap/long-term-unknown
Aug 18, 2026
Systemic proteome adaptions to 7-day complete caloric restriction in humans
gap/contradictory-evidence
Aug 18, 2026
Smad3-dependent regulation of type I collagen in human dermal fibroblasts: Impact on human skin connective tissue aging
gap/no-fulltext-access
gap/no-mechanism
gap/needs-replication
Aug 18, 2026
Epigenetic Skin Aging and Its Reversal to Improve Skin Longevity across Ethnicities and Phototypes Using a Dihydromyricetin-Containing Serum: Results from a Prospective, Single-Cohort Study
gap/no-mechanism
gap/needs-replication
Aug 18, 2026
Semaglutide ameliorates osteoarthritis progression through a weight loss-independent metabolic restoration mechanism
gap/needs-pdf-verification
gap/needs-replication
Aug 18, 2026
Endothelial Notch activity promotes angiogenesis and osteogenesis in bone
gap/needs-human-replication
gap/needs-replication
gap/no-mechanism
gap/dose-response-unclear
Aug 18, 2026
A damage accumulation model identifies distinct aging regimes across species
gap/needs-verification
Aug 18, 2026
Targeting iron-associated protein Ftl1 in the brain of old mice improves age-related cognitive impairment
gap/needs-replication
gap/needs-human-replication
gap/no-mechanism
gap/needs-sex-stratification
gap/dose-response-unclear
gap/long-term-unknown
Aug 18, 2026
p16INK4A is a robust in vivo biomarker of cellular aging in human skin
gap/no-fulltext-access
gap/needs-fulltext-verification
gap/no-mechanism
gap/contradictory-evidence
Aug 18, 2026
Injectable 'Skin Boosters' in Aging Skin Rejuvenation: A Current Overview
Aug 18, 2026
Fish-oil supplementation enhances the effects of strength training in elderly women
gap/no-fulltext-access
gap/no-mechanism
gap/needs-replication
Aug 18, 2026
Brain clearance is reduced during sleep and anesthesia
gap/needs-replication
gap/contradictory-evidence
gap/needs-human-replication
Aug 18, 2026
The Immunoglobulin G Glycome: A Modifiable Biomarker and Functional Effector of Aging, Disease, and Mortality
gap/needs-peer-review
gap/needs-replication
Aug 18, 2026
The lifespan of Korean eunuchs
Aug 18, 2026
Effects of lifelong testosterone exposure on health and disease using Mendelian randomization
gap/contradictory-evidence
Aug 18, 2026
Senescence atlas reveals an aged-like inflamed niche that blunts muscle regeneration
gap/needs-human-replication
gap/needs-replication
stub
Aug 18, 2026
Intermittent Supplementation With Fisetin Improves Physical Function and Decreases Cellular Senescence in Skeletal Muscle With Aging: A Comparison to Genetic Clearance of Senescent Cells and Synthetic Senolytic Approaches
gap/needs-replication
gap/needs-human-replication
stub
Aug 18, 2026
Effect of Salt Substitution on Cardiovascular Events and Death
Aug 18, 2026
Similarities and differences between IL11 and IL11RA1 knockout mice for lung fibro-inflammation, fertility and craniosynostosis
gap/needs-human-replication
Aug 18, 2026
In Vivo Amelioration of Age-Associated Hallmarks by Partial Reprogramming
gap/needs-human-replication
gap/long-term-unknown
gap/needs-replication
gap/dose-response-unclear
gap/stub
Aug 18, 2026
Urinary Sodium and Potassium Excretion, Mortality, and Cardiovascular Events
gap/contradictory-evidence
Aug 18, 2026
Therapeutic inhibition of telomeric DNA damage response rescues hematopoietic dysfunction driven by telomere shortening and aging
gap/long-term-unknown
gap/no-mechanism
gap/needs-human-replication
gap/needs-replication
Aug 18, 2026
A dual mTOR/NAD+ acting gerotherapy
gap/needs-human-replication
Aug 18, 2026
Ribosome dysregulation and intervention in age-related infertility
gap/needs-replication
gap/long-term-unknown
gap/no-mechanism
gap/needs-human-replication
gap/dose-response-unclear
Aug 18, 2026
Ferulic Acid Stabilizes a Solution of Vitamins C and E and Doubles its Photoprotection of Skin
gap/no-mechanism
gap/needs-human-replication
gap/dose-response-unclear
stub
gap/long-term-unknown
gap/needs-replication
Aug 18, 2026
Nuclear cGAS suppresses DNA repair and promotes tumorigenesis
gap/no-fulltext-access
gap/no-mechanism
gap/needs-human-replication
Aug 18, 2026
Senolytic treatment induces oligodendrocyte dysfunction and demyelination in the corpus callosum
gap/needs-human-replication
gap/needs-replication
gap/no-mechanism
Aug 18, 2026
The Hallmarks of Aging
Aug 18, 2026
Hallmarks of aging: An expanding universe
Aug 18, 2026
Reprogramming to recover youthful epigenetic information and restore vision
gap/needs-human-replication
gap/needs-replication
gap/stub
Aug 18, 2026
Berberine treats atherosclerosis via a vitamine-like effect down-regulating Choline-TMA-TMAO production pathway in gut microbiota
gap/needs-replication
gap/long-term-unknown
gap/needs-human-replication
Aug 18, 2026
Experimental Evidence Against Taurine Deficiency as a Driver of Aging in Humans
Aug 18, 2026
Ancestral protein reconstruction reveals the mechanism of substrate specificity in FN3K-mediated deglycation
gap/needs-peer-review
gap/needs-replication
Aug 18, 2026
Odanacatib for the treatment of postmenopausal osteoporosis: results of the LOFT multicentre, randomised, double-blind, placebo-controlled trial and LOFT Extension study
gap/no-mechanism
gap/no-fulltext-access
gap/needs-replication
Aug 18, 2026
Liraglutide, a glucagon-like peptide 1 receptor agonist, exerts analgesic, anti-inflammatory and anti-degradative actions in osteoarthritis
Aug 18, 2026
Adult skull bone marrow is an expanding and resilient haematopoietic reservoir
gap/contradictory-evidence
gap/needs-replication
gap/needs-human-replication
gap/no-mechanism
Aug 18, 2026
Berberine is a novel cholesterol-lowering drug working through a unique mechanism distinct from statins
gap/no-fulltext-access
gap/no-mechanism
gap/needs-replication
Aug 18, 2026
Dietary salt intake and cardiovascular outcomes: an umbrella review of meta-analyses and dose-response evidence
Aug 18, 2026
Astaxanthin, meclizine, mitoglitazone, pioglitazone, alpha-ketoglutarate, mifepristone, methotrexate, and atorvastatin-telmisartan do not increase lifespan in UM-HET3 mice
gap/no-fulltext-access
gap/contradictory-evidence
gap/needs-n-confirmation
gap/no-mechanism
gap/dose-response-unclear
Aug 18, 2026
Role of fibroblast-derived growth factors in regulating hyperpigmentation of solar lentigo
gap/no-fulltext-access
gap/contradictory-evidence
Aug 18, 2026
Impairment of paravascular clearance pathways in the aging brain
gap/no-mechanism
gap/needs-human-replication
gap/needs-replication
Aug 18, 2026
Ink4a/Arf expression is a biomarker of aging
gap/needs-replication
gap/needs-human-replication
Aug 18, 2026
The skin aging exposome
gap/needs-canonical-id
gap/needs-replication
gap/unsourced
gap/long-term-unknown
Aug 18, 2026
Subgroup Analysis from a Phase 1/2 Randomized Clinical Trial of 2.6% EDTA Ophthalmic Solution in Patients with Age-Related Cataract
gap/no-fulltext-access
gap/needs-replication
Aug 18, 2026
Coupling of angiogenesis and osteogenesis by a specific vessel subtype in bone
gap/needs-human-replication
gap/needs-page
Aug 18, 2026
Age-dependent modulation of vascular niches for haematopoietic stem cells
gap/needs-replication
gap/needs-human-replication
gap/no-mechanism
gap/needs-corrigendum-review
gap/long-term-unknown
gap/dose-response-unclear
Aug 18, 2026
Fermented-Food Metagenomics Reveals Substrate-Associated Differences in Taxonomy and Health-Associated and Antibiotic Resistance Determinants
gap/needs-human-replication
Aug 18, 2026
Berberine and adiposity in diabetes-free individuals with obesity and MASLD: a randomized clinical trial
gap/needs-replication
gap/contradictory-evidence
gap/dose-response-unclear
gap/long-term-unknown
Aug 18, 2026
The Epidermal Stem Cell Factor Is Over-Expressed in Lentigo Senilis: Implication for the Mechanism of Hyperpigmentation
gap/needs-replication
gap/needs-canonical-id
gap/contradictory-evidence
gap/no-mechanism
Aug 18, 2026
DNA methylation age of human tissues and cell types
gap/no-mechanism
gap/needs-replication
gap/unsourced
gap/contradictory-evidence
Aug 18, 2026
Sunscreen and prevention of skin aging: a randomized trial
gap/no-fulltext-access
gap/needs-replication
gap/long-term-unknown
Aug 18, 2026
Progression of Early Subclinical Atherosclerosis (PESA) Study: JACC Focus Seminar 7/8
gap/no-fulltext-access
Aug 18, 2026
Survey of senescent cell markers with age in human tissues
gap/needs-replication
gap/no-mechanism
Aug 18, 2026
Genotoxic stress abrogates renewal of melanocyte stem cells by triggering their differentiation
gap/needs-replication
gap/needs-human-replication
gap/no-mechanism
Aug 18, 2026
Discovery and characterization of antitumor gut microbiota from amphibians and reptiles: Ewingella americana as a novel therapeutic agent with dual cytotoxic and immunomodulatory properties
gap/needs-human-replication
gap/needs-supp-verification
gap/genome-not-sequenced
gap/no-mechanism
gap/needs-precedent-citation
gap/needs-replication
Aug 18, 2026
Metagenomic analysis of kimchi, a traditional Korean fermented food
gap/needs-human-replication
Aug 18, 2026
Super-adjuvant nanoparticles for platform cancer vaccination
gap/needs-human-replication
gap/needs-replication
Aug 18, 2026
Senescent cell turnover slows with age providing an explanation for the Gompertz law
gap/needs-human-replication
gap/needs-replication
Aug 18, 2026
Safety and pharmacodynamics of the ferroportin inhibitor vamifeport in patients with non-transfusion-dependent Ī²-thalassemia: results from a randomized phase 2a study
gap/long-term-unknown
gap/unverifiable-from-main-text
gap/needs-replication
gap/needs-human-replication
stub
Aug 18, 2026
Frailty phenotype reveals heterogeneity in aging and distinct taurine associations
Aug 18, 2026
Somatic mutations impose an entropic upper bound on human lifespan
gap/needs-replication
gap/no-mechanism
Aug 18, 2026
Identification of dihydromyricetin as a natural DNA methylation inhibitor with rejuvenating activity in human skin
gap/no-mechanism
gap/needs-replication
gap/needs-human-replication
gap/long-term-unknown
Aug 18, 2026
A spatial multi-omics atlas of immunosenescence reveals germinal-center B cell alteration in human lymph nodes
gap/no-fulltext-access
gap/abstract-unavailable
Aug 18, 2026
Effect of Long-Term Exposure to Lower Low-Density Lipoprotein Cholesterol Beginning Early in Life on the Risk of Coronary Heart Disease: A Mendelian Randomization Analysis
gap/no-fulltext-access
Aug 18, 2026
Is taurine an aging biomarker?
gap/no-fulltext-access
Aug 18, 2026
Molecular basis of sun-induced premature skin ageing and retinoid antagonism
Aug 18, 2026
Collagen Fragmentation Promotes Oxidative Stress and Elevates Matrix Metalloproteinase-1 in Fibroblasts in Aged Human Skin
gap/unsourced
gap/needs-human-replication
gap/needs-replication
gap/no-mechanism
Aug 18, 2026
Cell surface ATP6V1B2 marks a subset of persistent senescent cells with increased resistance to apoptosis
gap/preprint-not-peer-reviewed
gap/no-fulltext-access
gap/needs-replication
gap/no-mechanism
Aug 18, 2026
Cognitive and affective effects of L-Theanine: a systematic review and meta-analysis of 31 randomized trials
gap/no-fulltext-access
Aug 18, 2026
Exceptional Longevity Modifying Allele APOE2 Promotes DNA Signaling Pathways Resisting Cellular Senescence in Human Neurons
Aug 18, 2026
Effect of changes in potassium intake on blood pressure: a doseāresponse meta-analysis of randomized clinical trials (2000ā2024)
Aug 18, 2026
Mortality and survival: comparison of eunuchs with intact men and women in a mentally retarded population
gap/no-fulltext-access
Aug 18, 2026
Astaxanthin and meclizine extend lifespan in UM-HET3 male mice; fisetin, SG1002 (hydrogen sulfide donor), dimethyl fumarate, mycophenolic acid, and 4-phenylbutyrate do not significantly affect lifespan in either sex at the doses and schedules used
gap/no-mechanism
gap/contradictory-evidence
gap/dose-response-unclear
gap/stub
Aug 18, 2026
Using genetics to investigate the association between lanosterol and cataract
gap/contradictory-evidence
Aug 18, 2026
A cGAS-mediated mechanism in naked mole-rats potentiates DNA repair and delays aging
gap/no-fulltext-access
gap/no-mechanism
gap/needs-human-replication
gap/needs-replication
Aug 18, 2026
Single-cell quantification of senescence burden reveals cell type-specific ageing dynamics across organs
gap/preprint-not-peer-reviewed
gap/no-fulltext-access
Aug 18, 2026
Test of Rapamycin in Aging Dogs (TRIAD): study design and rationale for a prospective, parallel-group, double-masked, randomized, placebo-controlled, multicenter trial of rapamycin in healthy middle-aged dogs from the Dog Aging Project
gap/needs-citation-verification
gap/long-term-unknown
gap/needs-nct-id-confirmation
stub
gap/no-disclosure
Aug 18, 2026
Prolonged fasting promotes systemic inflammation and platelet activation in humans: a medically supervised, water-only fasting and refeeding study
Aug 18, 2026
Joint Effects of Sodium and Potassium Intake on Subsequent Cardiovascular Disease: The Trials of Hypertension Prevention Follow-up Study
gap/no-fulltext-access
Aug 18, 2026
Modulation of circulating levels of advanced glycation end products and its impact on intima-media thickness of both common carotid arteries: CORDIOPREV randomised controlled trial
gap/needs-replication
gap/long-term-unknown
Aug 18, 2026
Semaglutide Slows Epigenetic Aging in People with HIV-associated lipohypertrophy: Evidence from a Randomized Controlled Trial
gap/needs-healthy-population-replication
gap/long-term-unknown
Aug 18, 2026
An open science study of ageing in companion dogs
gap/needs-replication
gap/long-term-unknown
gap/needs-citation-verification
Aug 18, 2026
Analysis of physiological and biochemical changes and metabolic shifts during 21-Day fasting hypometabolism
Aug 18, 2026
Failure of Oxysterols Such as Lanosterol to Restore Lens Clarity from Cataracts
gap/contradictory-evidence
Aug 18, 2026
Enzymatic Deglycation of Damaged Skin by Means of Combined Treatment of Fructosamine-3-Kinase and Fructosyl-Amino Acid Oxidase
gap/needs-replication
gap/long-term-unknown
Aug 18, 2026
An Essential Role for Senescent Cells in Optimal Wound Healing through Secretion of PDGF-AA
gap/needs-replication
gap/needs-human-replication
Aug 18, 2026
Senolytic treatment rescues blunted muscle hypertrophy in old mice
gap/no-mechanism
gap/needs-human-replication
gap/needs-replication
gap/needs-canonical-ref-synergist-ablation
Aug 18, 2026
README
Aug 18, 2026
Genetic background sets the trajectory of experimental cancer evolution
gap/needs-human-replication
gap/needs-replication
gap/no-mechanism
Aug 18, 2026
Ovarian stiffness increases with age in the mammalian ovary and depends on collagen and hyaluronan matrices
gap/needs-human-replication
Aug 18, 2026
SenCat: Cataloging human cell senescence through multi-omic profiling of multiple senescent primary cell types
gap/no-fulltext-access
Aug 18, 2026
Reevaluating the Threshold for Low Total Testosterone
Aug 18, 2026
Clearance of p16Ink4a-positive senescent cells delays ageing-associated disorders
gap/needs-replication
gap/needs-stub-expansion
Aug 18, 2026
Naturally occurring p16Ink4a-positive cells shorten healthy lifespan
gap/needs-human-replication
gap/dose-response-unclear
gap/no-fulltext-access
Aug 18, 2026
Regeneration of neuromuscular synapses after acute and chronic denervation by inhibiting the gerozyme 15-prostaglandin dehydrogenase
gap/needs-human-replication
gap/needs-replication
gap/no-mechanism
gap/needs-verification
gap/long-term-unknown
gap/dose-response-unclear
Aug 18, 2026
The effects of fermented vegetables on the gut microbiota for prevention of cardiovascular disease
gap/contradictory-evidence
Aug 18, 2026
Autoantibodies neutralizing type I IFNs are present in ~4% of uninfected individuals over 70 years old and account for ~20% of COVID-19 deaths
gap/needs-replication
gap/no-mechanism
gap/dose-response-unclear
gap/long-term-unknown
Aug 18, 2026
Dynamics of human gut microbiota and short-chain fatty acids in response to dietary interventions with three fermentable fibers
gap/needs-replication
gap/no-mechanism
Aug 18, 2026
Thymic health consequences in adults
gap/no-fulltext-access
gap/no-mechanism
gap/needs-replication
Aug 18, 2026
Thymic health and immunotherapy outcomes in patients with cancer
gap/no-fulltext-access
gap/needs-replication
gap/no-mechanism
gap/contradictory-evidence
Aug 18, 2026
Individual and additive effects of vitamin D, omega-3 and exercise on DNA methylation clocks of biological aging in older adults from the DO-HEALTH trial
gap/needs-replication
gap/long-term-unknown
Aug 18, 2026
Lymphatic vessels in bone support regeneration after injury
gap/needs-human-replication
gap/needs-replication
Aug 18, 2026
Increased skin autofluorescence predicts future cancer development
gap/no-mechanism
gap/needs-replication
gap/needs-human-replication
Aug 18, 2026
Reduced DNA methylation patterning and transcriptional connectivity define human skin aging
gap/needs-replication
gap/no-mechanism
Aug 18, 2026
Beneficial effects of vitamins D and K on the elastic properties of the vessel wall in postmenopausal women: a follow-up study
gap/no-fulltext-access
gap/needs-fulltext
gap/needs-replication
gap/dose-response-unclear
Aug 18, 2026
Lanosterol and 25-hydroxycholesterol dissociate crystallin aggregates isolated from cataractous human lens via different mechanisms
gap/no-fulltext-access
gap/contradictory-evidence
Aug 18, 2026
Berberine versus placebo for the prevention of recurrence of colorectal adenoma: a multicentre, double-blinded, randomised controlled study
gap/no-fulltext-access
gap/unsourced
gap/needs-replication
gap/no-mechanism
gap/long-term-unknown