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gap
1003 items with this tag.
Aug 31, 2026
testis
gap/needs-human-replication
gap/no-fulltext-access
Aug 31, 2026
thymus
gap/no-fulltext-access
gap/no-mechanism
Aug 31, 2026
thyroid
gap/needs-replication
gap/unsourced
gap/contradictory-evidence
Aug 31, 2026
uterus
gap/needs-human-replication
gap/no-fulltext-access
Aug 31, 2026
vagus-nerve
gap/unsourced
gap/needs-human-replication
gap/contradictory-evidence
gap/no-mechanism
Aug 31, 2026
veins
gap/no-mechanism
gap/unsourced
gap/needs-replication
Aug 31, 2026
white-adipose-tissue
gap/needs-page
gap/needs-human-replication
gap/no-mechanism
Aug 31, 2026
myocardium
gap/unsourced
gap/needs-replication
gap/needs-human-replication
Aug 31, 2026
ovary
gap/no-mechanism
gap/needs-replication
gap/long-term-unknown
gap/no-fulltext-access
Aug 31, 2026
parathyroid
gap/unsourced
gap/dose-response-unclear
gap/contradictory-evidence
gap/long-term-unknown
gap/no-fulltext-access
Aug 31, 2026
periodontal-ligament
gap/dose-response-unclear
gap/no-mechanism
gap/needs-human-replication
Aug 31, 2026
prostate
gap/no-fulltext-access
gap/needs-human-replication
gap/long-term-unknown
Aug 31, 2026
skeletal-muscle
gap/unsourced
gap/needs-human-replication
gap/no-fulltext-access
Aug 31, 2026
skin
gap/unsourced
gap/needs-replication
gap/no-mechanism
gap/no-fulltext-access
Aug 31, 2026
breast
gap/contradictory-evidence
gap/needs-replication
gap/no-mechanism
gap/no-fulltext-access
Aug 31, 2026
dermis
gap/unsourced
gap/contradictory-evidence
gap/no-mechanism
gap/needs-replication
gap/needs-human-replication
Aug 31, 2026
epidermis
gap/unsourced
gap/needs-replication
gap/needs-human-replication
gap/no-fulltext-access
gap/needs-pdf-verification
Aug 31, 2026
gingiva
gap/no-fulltext-access
gap/needs-replication
gap/unsourced
gap/contradictory-evidence
gap/needs-human-replication
gap/needs-verification
Aug 31, 2026
heart
gap/unsourced
gap/needs-replication
gap/needs-human-replication
gap/no-fulltext-access
Aug 31, 2026
lens
gap/needs-human-replication
gap/no-mechanism
gap/needs-replication
Aug 31, 2026
liver
gap/needs-replication
gap/needs-human-replication
gap/unsourced
gap/long-term-unknown
Aug 31, 2026
Lanosterol reverses protein aggregation in cataracts
gap/needs-human-replication
gap/needs-replication
gap/needs-supp-verification
gap/contradictory-evidence
Aug 31, 2026
Nuclear cGAS restricts L1 retrotransposition by promoting TRIM41-mediated ORF2p ubiquitination and degradation
gap/needs-human-replication
gap/no-mechanism
gap/needs-replication
Aug 31, 2026
Berberine ameliorates atherosclerosis by inhibiting the phenotypic transition of vascular smooth muscle cells via suppression of the JAK2/STAT3 signaling pathway
gap/needs-pdf-fetch
gap/needs-replication
gap/no-mechanism
gap/dose-response-unclear
gap/needs-human-replication
Aug 31, 2026
alveolar-bone
gap/needs-replication
gap/needs-human-replication
gap/contradictory-evidence
gap/no-fulltext-access
Aug 31, 2026
arteries
gap/needs-replication
gap/no-mechanism
gap/needs-human-replication
gap/no-fulltext-access
Aug 31, 2026
bone-marrow
gap/unsourced
gap/contradictory-evidence
gap/needs-replication
gap/needs-human-replication
Aug 31, 2026
bone
gap/unsourced
gap/needs-replication
gap/contradictory-evidence
gap/needs-human-replication
Aug 31, 2026
brain
gap/unsourced
gap/contradictory-evidence
gap/needs-human-replication
gap/needs-replication
gap/no-mechanism
Aug 31, 2026
Modulating IL-11-dependent matrix stiffness to delay ovarian aging
gap/needs-human-replication
gap/needs-replication
gap/long-term-unknown
gap/no-mechanism
gap/dose-response-unclear
Aug 31, 2026
Sleep Drives Metabolite Clearance from the Adult Brain
gap/source-discrepancy
gap/no-mechanism
gap/needs-human-replication
gap/needs-replication
Aug 31, 2026
Targeting senescent cells enhances adipogenesis and metabolic function in old age
gap/needs-human-replication
gap/dose-response-unclear
Aug 31, 2026
Efficacy and safety of berberine for several cardiovascular diseases: a systematic review and meta-analysis of randomized controlled trials
gap/no-fulltext-access
gap/no-mechanism
gap/contradictory-evidence
gap/dose-response-unclear
Aug 31, 2026
Loss of epigenetic information as a cause of mammalian aging
gap/needs-replication
gap/needs-human-replication
gap/unsourced
gap/long-term-unknown
Aug 31, 2026
Tobacco smoking and somatic mutations in human bronchial epithelium
gap/intercept-not-reported
gap/dose-response-unclear
gap/no-mechanism
gap/needs-replication
gap/unsourced
Aug 31, 2026
Ruminococcus bromii is a keystone species for the degradation of resistant starch in the human colon
gap/needs-human-replication
Aug 31, 2026
Targeting Cancer-Specific Mutations with RNA-Triggered Chromatin Shredding
gap/no-mechanism
gap/long-term-unknown
gap/no-fulltext-access
Aug 31, 2026
Inhibitory effect of lanosterol on cataractous lens of cynomolgus monkeys using a subconjunctival drug release system
gap/needs-replication
gap/needs-human-replication
Aug 31, 2026
Increased hyaluronan by naked mole-rat Has2 improves healthspan in mice
gap/contradictory-evidence
gap/needs-replication
gap/dose-response-unclear
gap/no-mechanism
gap/needs-human-replication
Aug 31, 2026
Reversal of protein chemical aging by enzymatic deglycation
gap/needs-human-replication
gap/needs-replication
gap/long-term-unknown
Aug 31, 2026
Senescence in tissue samples of humans with age-related diseases: A systematic review
gap/no-fulltext-access
Aug 31, 2026
p53 mutant mice that display early ageing-associated phenotypes
gap/needs-human-replication
Aug 31, 2026
Universal transcriptomic hallmarks of mammalian ageing and mortality
gap/needs-human-replication
gap/no-mechanism
Aug 31, 2026
In Vivo Base Editing of PCSK9 with VERVE-102 for Hypercholesterolemia
gap/long-term-unknown
gap/needs-human-replication
gap/needs-replication
gap/no-mechanism
Aug 31, 2026
Mitochondrial oxidative stress caused by Sod2 deficiency promotes cellular senescence and aging phenotypes in the skin
gap/unsourced
gap/needs-human-replication
Aug 31, 2026
Variable responses of human microbiomes to dietary supplementation with resistant starch
gap/needs-replication
Aug 31, 2026
Gut-microbiota-targeted diets modulate human immune status
gap/needs-replication
gap/long-term-unknown
Aug 31, 2026
Effect of long-term caloric restriction on DNA methylation measures of biological aging in healthy adults from the CALERIEâ„¢ trial
gap/needs-replication
gap/long-term-unknown
Aug 31, 2026
Inhibition of IL-11 signalling extends mammalian healthspan and lifespan
gap/needs-human-replication
gap/needs-replication
gap/dose-response-unclear
gap/long-term-unknown
Aug 31, 2026
Inhibition of 15-hydroxy prostaglandin dehydrogenase promotes cartilage regeneration
gap/needs-replication
gap/no-mechanism
gap/long-term-unknown
gap/needs-human-replication
Aug 31, 2026
Dietary omega-3 fatty acid supplementation increases the rate of muscle protein synthesis in older adults: a randomized controlled trial
gap/needs-replication
gap/no-mechanism
Aug 31, 2026
Fish oil-derived n-3 PUFA therapy increases muscle mass and function in healthy older adults
gap/contradictory-evidence
gap/needs-replication
gap/long-term-unknown
Aug 31, 2026
Ocular delivery of lipid nanoparticles-formulated mRNA encoding lanosterol synthase ameliorates cataract in rats
gap/needs-human-replication
gap/needs-replication
gap/long-term-unknown
Aug 31, 2026
Tretinoin (0.05% cream vs. 5% peel) for photoaging and field cancerization of the forearms: randomized, evaluator-blinded, clinical trial
gap/no-fulltext-access
gap/needs-replication
gap/dose-response-unclear
gap/long-term-unknown
Aug 31, 2026
Cardiovascular Outcomes with Tirzepatide versus Dulaglutide in Type 2 Diabetes
gap/no-fulltext-access
gap/contradictory-evidence
gap/needs-pdf-verification
gap/no-mechanism
gap/needs-replication
Aug 31, 2026
SenNet recommendations for detecting senescent cells in different tissues
gap/no-fulltext-access
Aug 31, 2026
Charting human cellular senescence in aging and disease
gap/no-fulltext-access
Aug 31, 2026
Berberine for preventing colorectal adenoma recurrence and neoplasm occurrence: 6-year follow-up of a randomized clinical trial
gap/no-mechanism
Aug 31, 2026
RESULTS: FROM A RANDOMIZED CLINICAL TRIAL EVALUATING THE SENOLYTIC FISETIN FOR TREATING KNEE OSTEOARTHRITIS
gap/needs-full-paper-publication
gap/needs-replication
gap/no-mechanism
gap/dose-response-unclear
gap/needs-human-replication
stub
Aug 31, 2026
Disrupted glymphatic function and its relationship with sleep and cognitive impairment in ME/CFS assessed via DTI-ALPS
gap/no-mechanism
gap/needs-replication
Aug 31, 2026
The effects of omega-3 polyunsaturated fatty acids on muscle and whole-body protein synthesis: a systematic review and meta-analysis
gap/needs-replication
gap/long-term-unknown
Aug 31, 2026
Targeting iron-associated protein Ftl1 in the brain of old mice improves age-related cognitive impairment
gap/needs-replication
gap/needs-human-replication
gap/no-mechanism
gap/needs-sex-stratification
gap/dose-response-unclear
gap/long-term-unknown
Aug 31, 2026
p16INK4A is a robust in vivo biomarker of cellular aging in human skin
gap/no-fulltext-access
gap/needs-fulltext-verification
gap/no-mechanism
gap/contradictory-evidence
Aug 31, 2026
Fish-oil supplementation enhances the effects of strength training in elderly women
gap/no-fulltext-access
gap/no-mechanism
gap/needs-replication
Aug 31, 2026
Non-invasive epidermis sampling for DNA methylation-based prediction of skin cancer phenotypes
gap/needs-human-replication
gap/needs-replication
gap/no-mechanism
gap/not-reported
Aug 31, 2026
Using human genetics to understand the disease impacts of testosterone in men and women
gap/no-narrative-or-stated
gap/contradictory-evidence
Aug 31, 2026
The Influence of n-3PUFA Supplementation on Muscle Strength, Mass, and Function: A Systematic Review and Meta-Analysis
gap/contradictory-evidence
Aug 31, 2026
IL-11 is a crucial determinant of cardiovascular fibrosis
gap/needs-human-replication
Aug 31, 2026
Biological aging and lifespan in men and women using a Mendelian randomization study
gap/needs-replication
gap/contradictory-evidence
Aug 31, 2026
Effect of lanosterol on human cataract nucleus
gap/contradictory-evidence
Aug 31, 2026
Taurine from tumour niche drives glycolysis to promote leukaemogenesis
gap/needs-human-replication
Aug 31, 2026
Vitamin K supplementation and progression of coronary artery calcium in older men and women
gap/no-mechanism
gap/needs-replication
gap/dose-response-unclear
Aug 31, 2026
Taurine deficiency as a driver of aging
gap/needs-human-replication
gap/needs-replication
Aug 31, 2026
Urinary Sodium and Potassium Excretion, Mortality, and Cardiovascular Events
gap/contradictory-evidence
Aug 31, 2026
Therapeutic inhibition of telomeric DNA damage response rescues hematopoietic dysfunction driven by telomere shortening and aging
gap/long-term-unknown
gap/no-mechanism
gap/needs-human-replication
gap/needs-replication
Aug 31, 2026
Impact of polyphenol oxidase on the bioavailability of flavan-3-ols in fruit smoothies: a controlled, single blinded, cross-over study
gap/needs-replication
gap/long-term-unknown
gap/no-mechanism
Aug 31, 2026
Inhibition of prostaglandin-degrading enzyme 15-PGDH rejuvenates aged muscle mass and strength
gap/unsourced
gap/needs-replication
gap/dose-response-unclear
gap/needs-human-replication
gap/long-term-unknown
Aug 31, 2026
Systemic proteome adaptions to 7-day complete caloric restriction in humans
gap/contradictory-evidence
Aug 31, 2026
Smad3-dependent regulation of type I collagen in human dermal fibroblasts: Impact on human skin connective tissue aging
gap/no-fulltext-access
gap/no-mechanism
gap/needs-replication
Aug 31, 2026
Epigenetic Skin Aging and Its Reversal to Improve Skin Longevity across Ethnicities and Phototypes Using a Dihydromyricetin-Containing Serum: Results from a Prospective, Single-Cohort Study
gap/no-mechanism
gap/needs-replication
Aug 31, 2026
Semaglutide ameliorates osteoarthritis progression through a weight loss-independent metabolic restoration mechanism
gap/needs-pdf-verification
gap/needs-replication
Aug 31, 2026
Endothelial Notch activity promotes angiogenesis and osteogenesis in bone
gap/needs-human-replication
gap/needs-replication
gap/no-mechanism
gap/dose-response-unclear
Aug 31, 2026
A damage accumulation model identifies distinct aging regimes across species
gap/needs-verification
Aug 31, 2026
Ancestral protein reconstruction reveals the mechanism of substrate specificity in FN3K-mediated deglycation
gap/needs-peer-review
gap/needs-replication
Aug 31, 2026
Odanacatib for the treatment of postmenopausal osteoporosis: results of the LOFT multicentre, randomised, double-blind, placebo-controlled trial and LOFT Extension study
gap/no-mechanism
gap/no-fulltext-access
gap/needs-replication
Aug 31, 2026
Brain clearance is reduced during sleep and anesthesia
gap/needs-replication
gap/contradictory-evidence
gap/needs-human-replication
Aug 31, 2026
The Immunoglobulin G Glycome: A Modifiable Biomarker and Functional Effector of Aging, Disease, and Mortality
gap/needs-peer-review
gap/needs-replication
Aug 31, 2026
Effects of lifelong testosterone exposure on health and disease using Mendelian randomization
gap/contradictory-evidence
Aug 31, 2026
Senescence atlas reveals an aged-like inflamed niche that blunts muscle regeneration
gap/needs-human-replication
gap/needs-replication
stub
Aug 31, 2026
Intermittent Supplementation With Fisetin Improves Physical Function and Decreases Cellular Senescence in Skeletal Muscle With Aging: A Comparison to Genetic Clearance of Senescent Cells and Synthetic Senolytic Approaches
gap/needs-replication
gap/needs-human-replication
stub
Aug 31, 2026
Similarities and differences between IL11 and IL11RA1 knockout mice for lung fibro-inflammation, fertility and craniosynostosis
gap/needs-human-replication
Aug 31, 2026
In Vivo Amelioration of Age-Associated Hallmarks by Partial Reprogramming
gap/needs-human-replication
gap/long-term-unknown
gap/needs-replication
gap/dose-response-unclear
gap/stub
Aug 31, 2026
Age-dependent modulation of vascular niches for haematopoietic stem cells
gap/needs-replication
gap/needs-human-replication
gap/no-mechanism
gap/needs-corrigendum-review
gap/long-term-unknown
gap/dose-response-unclear
Aug 31, 2026
Fermented-Food Metagenomics Reveals Substrate-Associated Differences in Taxonomy and Health-Associated and Antibiotic Resistance Determinants
gap/needs-human-replication
Aug 31, 2026
Berberine and adiposity in diabetes-free individuals with obesity and MASLD: a randomized clinical trial
gap/needs-replication
gap/contradictory-evidence
gap/dose-response-unclear
gap/long-term-unknown
Aug 31, 2026
A dual mTOR/NAD+ acting gerotherapy
gap/needs-human-replication
Aug 31, 2026
Ribosome dysregulation and intervention in age-related infertility
gap/needs-replication
gap/long-term-unknown
gap/no-mechanism
gap/needs-human-replication
gap/dose-response-unclear
Aug 31, 2026
Ferulic Acid Stabilizes a Solution of Vitamins C and E and Doubles its Photoprotection of Skin
gap/no-mechanism
gap/needs-human-replication
gap/dose-response-unclear
stub
gap/long-term-unknown
gap/needs-replication
Aug 31, 2026
Nuclear cGAS suppresses DNA repair and promotes tumorigenesis
gap/no-fulltext-access
gap/no-mechanism
gap/needs-human-replication
Aug 31, 2026
Senolytic treatment induces oligodendrocyte dysfunction and demyelination in the corpus callosum
gap/needs-human-replication
gap/needs-replication
gap/no-mechanism
Aug 31, 2026
Reprogramming to recover youthful epigenetic information and restore vision
gap/needs-human-replication
gap/needs-replication
gap/stub
Aug 31, 2026
Berberine treats atherosclerosis via a vitamine-like effect down-regulating Choline-TMA-TMAO production pathway in gut microbiota
gap/needs-replication
gap/long-term-unknown
gap/needs-human-replication
Aug 31, 2026
Plasminogen activator inhibitor 1 promotes aortic aging-like pathophysiology in humans and mice
gap/needs-replication
gap/needs-human-replication
gap/no-mechanism
gap/long-term-unknown
Aug 31, 2026
Adult skull bone marrow is an expanding and resilient haematopoietic reservoir
gap/contradictory-evidence
gap/needs-replication
gap/needs-human-replication
gap/no-mechanism
Aug 31, 2026
Berberine is a novel cholesterol-lowering drug working through a unique mechanism distinct from statins
gap/no-fulltext-access
gap/no-mechanism
gap/needs-replication
Aug 31, 2026
Astaxanthin, meclizine, mitoglitazone, pioglitazone, alpha-ketoglutarate, mifepristone, methotrexate, and atorvastatin-telmisartan do not increase lifespan in UM-HET3 mice
gap/no-fulltext-access
gap/contradictory-evidence
gap/needs-n-confirmation
gap/no-mechanism
gap/dose-response-unclear
Aug 31, 2026
Role of fibroblast-derived growth factors in regulating hyperpigmentation of solar lentigo
gap/no-fulltext-access
gap/contradictory-evidence
Aug 31, 2026
Impairment of paravascular clearance pathways in the aging brain
gap/no-mechanism
gap/needs-human-replication
gap/needs-replication
Aug 31, 2026
Ink4a/Arf expression is a biomarker of aging
gap/needs-replication
gap/needs-human-replication
Aug 31, 2026
The skin aging exposome
gap/needs-canonical-id
gap/needs-replication
gap/unsourced
gap/long-term-unknown
Aug 31, 2026
Subgroup Analysis from a Phase 1/2 Randomized Clinical Trial of 2.6% EDTA Ophthalmic Solution in Patients with Age-Related Cataract
gap/no-fulltext-access
gap/needs-replication
Aug 31, 2026
Coupling of angiogenesis and osteogenesis by a specific vessel subtype in bone
gap/needs-human-replication
gap/needs-page
Aug 31, 2026
Sunscreen and prevention of skin aging: a randomized trial
gap/no-fulltext-access
gap/needs-replication
gap/long-term-unknown
Aug 31, 2026
Progression of Early Subclinical Atherosclerosis (PESA) Study: JACC Focus Seminar 7/8
gap/no-fulltext-access
Aug 31, 2026
Survey of senescent cell markers with age in human tissues
gap/needs-replication
gap/no-mechanism
Aug 31, 2026
Genotoxic stress abrogates renewal of melanocyte stem cells by triggering their differentiation
gap/needs-replication
gap/needs-human-replication
gap/no-mechanism
Aug 31, 2026
Discovery and characterization of antitumor gut microbiota from amphibians and reptiles: Ewingella americana as a novel therapeutic agent with dual cytotoxic and immunomodulatory properties
gap/needs-human-replication
gap/needs-supp-verification
gap/genome-not-sequenced
gap/no-mechanism
gap/needs-precedent-citation
gap/needs-replication
Aug 31, 2026
Metagenomic analysis of kimchi, a traditional Korean fermented food
gap/needs-human-replication
Aug 31, 2026
Super-adjuvant nanoparticles for platform cancer vaccination
gap/needs-human-replication
gap/needs-replication
Aug 31, 2026
Senescent cell turnover slows with age providing an explanation for the Gompertz law
gap/needs-human-replication
gap/needs-replication
Aug 31, 2026
Safety and pharmacodynamics of the ferroportin inhibitor vamifeport in patients with non-transfusion-dependent β-thalassemia: results from a randomized phase 2a study
gap/long-term-unknown
gap/unverifiable-from-main-text
gap/needs-replication
gap/needs-human-replication
stub
Aug 31, 2026
A null mutation in SERPINE1 protects against biological aging in humans
gap/no-mechanism
gap/needs-replication
Aug 31, 2026
Identification of dihydromyricetin as a natural DNA methylation inhibitor with rejuvenating activity in human skin
gap/no-mechanism
gap/needs-replication
gap/needs-human-replication
gap/long-term-unknown
Aug 31, 2026
A spatial multi-omics atlas of immunosenescence reveals germinal-center B cell alteration in human lymph nodes
gap/no-fulltext-access
gap/abstract-unavailable
Aug 31, 2026
Effect of Long-Term Exposure to Lower Low-Density Lipoprotein Cholesterol Beginning Early in Life on the Risk of Coronary Heart Disease: A Mendelian Randomization Analysis
gap/no-fulltext-access
Aug 31, 2026
Is taurine an aging biomarker?
gap/no-fulltext-access
Aug 31, 2026
Collagen Fragmentation Promotes Oxidative Stress and Elevates Matrix Metalloproteinase-1 in Fibroblasts in Aged Human Skin
gap/unsourced
gap/needs-human-replication
gap/needs-replication
gap/no-mechanism
Aug 31, 2026
Cell surface ATP6V1B2 marks a subset of persistent senescent cells with increased resistance to apoptosis
gap/preprint-not-peer-reviewed
gap/no-fulltext-access
gap/needs-replication
gap/no-mechanism
Aug 31, 2026
Cognitive and affective effects of L-Theanine: a systematic review and meta-analysis of 31 randomized trials
gap/no-fulltext-access
Aug 31, 2026
Mortality and survival: comparison of eunuchs with intact men and women in a mentally retarded population
gap/no-fulltext-access
Aug 31, 2026
Astaxanthin and meclizine extend lifespan in UM-HET3 male mice; fisetin, SG1002 (hydrogen sulfide donor), dimethyl fumarate, mycophenolic acid, and 4-phenylbutyrate do not significantly affect lifespan in either sex at the doses and schedules used
gap/no-mechanism
gap/contradictory-evidence
gap/dose-response-unclear
gap/stub
Aug 31, 2026
Using genetics to investigate the association between lanosterol and cataract
gap/contradictory-evidence
Aug 31, 2026
The Epidermal Stem Cell Factor Is Over-Expressed in Lentigo Senilis: Implication for the Mechanism of Hyperpigmentation
gap/needs-replication
gap/needs-canonical-id
gap/contradictory-evidence
gap/no-mechanism
Aug 31, 2026
DNA methylation age of human tissues and cell types
gap/no-mechanism
gap/needs-replication
gap/unsourced
gap/contradictory-evidence
Aug 31, 2026
Test of Rapamycin in Aging Dogs (TRIAD): study design and rationale for a prospective, parallel-group, double-masked, randomized, placebo-controlled, multicenter trial of rapamycin in healthy middle-aged dogs from the Dog Aging Project
gap/needs-citation-verification
gap/long-term-unknown
gap/needs-nct-id-confirmation
stub
gap/no-disclosure
Aug 31, 2026
Joint Effects of Sodium and Potassium Intake on Subsequent Cardiovascular Disease: The Trials of Hypertension Prevention Follow-up Study
gap/no-fulltext-access
Aug 31, 2026
Modulation of circulating levels of advanced glycation end products and its impact on intima-media thickness of both common carotid arteries: CORDIOPREV randomised controlled trial
gap/needs-replication
gap/long-term-unknown
Aug 31, 2026
Semaglutide Slows Epigenetic Aging in People with HIV-associated lipohypertrophy: Evidence from a Randomized Controlled Trial
gap/needs-healthy-population-replication
gap/long-term-unknown
Aug 31, 2026
An open science study of ageing in companion dogs
gap/needs-replication
gap/long-term-unknown
gap/needs-citation-verification
Aug 31, 2026
Failure of Oxysterols Such as Lanosterol to Restore Lens Clarity from Cataracts
gap/contradictory-evidence
Aug 31, 2026
Enzymatic Deglycation of Damaged Skin by Means of Combined Treatment of Fructosamine-3-Kinase and Fructosyl-Amino Acid Oxidase
gap/needs-replication
gap/long-term-unknown
Aug 31, 2026
An Essential Role for Senescent Cells in Optimal Wound Healing through Secretion of PDGF-AA
gap/needs-replication
gap/needs-human-replication
Aug 31, 2026
Senolytic treatment rescues blunted muscle hypertrophy in old mice
gap/no-mechanism
gap/needs-human-replication
gap/needs-replication
gap/needs-canonical-ref-synergist-ablation
Aug 31, 2026
Somatic mutations impose an entropic upper bound on human lifespan
gap/needs-replication
gap/no-mechanism
Aug 31, 2026
Autoantibodies neutralizing type I IFNs are present in ~4% of uninfected individuals over 70 years old and account for ~20% of COVID-19 deaths
gap/needs-replication
gap/no-mechanism
gap/dose-response-unclear
gap/long-term-unknown
Aug 31, 2026
Dynamics of human gut microbiota and short-chain fatty acids in response to dietary interventions with three fermentable fibers
gap/needs-replication
gap/no-mechanism
Aug 31, 2026
Thymic health consequences in adults
gap/no-fulltext-access
gap/no-mechanism
gap/needs-replication
Aug 31, 2026
Thymic health and immunotherapy outcomes in patients with cancer
gap/no-fulltext-access
gap/needs-replication
gap/no-mechanism
gap/contradictory-evidence
Aug 31, 2026
Individual and additive effects of vitamin D, omega-3 and exercise on DNA methylation clocks of biological aging in older adults from the DO-HEALTH trial
gap/needs-replication
gap/long-term-unknown
Aug 31, 2026
Lymphatic vessels in bone support regeneration after injury
gap/needs-human-replication
gap/needs-replication
Aug 31, 2026
Increased skin autofluorescence predicts future cancer development
gap/no-mechanism
gap/needs-replication
gap/needs-human-replication
Aug 31, 2026
Reduced DNA methylation patterning and transcriptional connectivity define human skin aging
gap/needs-replication
gap/no-mechanism
Aug 31, 2026
Beneficial effects of vitamins D and K on the elastic properties of the vessel wall in postmenopausal women: a follow-up study
gap/no-fulltext-access
gap/needs-fulltext
gap/needs-replication
gap/dose-response-unclear
Aug 31, 2026
Lanosterol and 25-hydroxycholesterol dissociate crystallin aggregates isolated from cataractous human lens via different mechanisms
gap/no-fulltext-access
gap/contradictory-evidence
Aug 31, 2026
Berberine versus placebo for the prevention of recurrence of colorectal adenoma: a multicentre, double-blinded, randomised controlled study
gap/no-fulltext-access
gap/unsourced
gap/needs-replication
gap/no-mechanism
gap/long-term-unknown
Aug 31, 2026
A cGAS-mediated mechanism in naked mole-rats potentiates DNA repair and delays aging
gap/no-fulltext-access
gap/no-mechanism
gap/needs-human-replication
gap/needs-replication
Aug 31, 2026
Single-cell quantification of senescence burden reveals cell type-specific ageing dynamics across organs
gap/preprint-not-peer-reviewed
gap/no-fulltext-access
Aug 31, 2026
Genetic background sets the trajectory of experimental cancer evolution
gap/needs-human-replication
gap/needs-replication
gap/no-mechanism
Aug 31, 2026
Ovarian stiffness increases with age in the mammalian ovary and depends on collagen and hyaluronan matrices
gap/needs-human-replication
Aug 31, 2026
SenCat: Cataloging human cell senescence through multi-omic profiling of multiple senescent primary cell types
gap/no-fulltext-access
Aug 31, 2026
Clearance of p16Ink4a-positive senescent cells delays ageing-associated disorders
gap/needs-replication
gap/needs-stub-expansion
Aug 31, 2026
Naturally occurring p16Ink4a-positive cells shorten healthy lifespan
gap/needs-human-replication
gap/dose-response-unclear
gap/no-fulltext-access
Aug 31, 2026
Regeneration of neuromuscular synapses after acute and chronic denervation by inhibiting the gerozyme 15-prostaglandin dehydrogenase
gap/needs-human-replication
gap/needs-replication
gap/no-mechanism
gap/needs-verification
gap/long-term-unknown
gap/dose-response-unclear
Aug 31, 2026
The effects of fermented vegetables on the gut microbiota for prevention of cardiovascular disease
gap/contradictory-evidence
Aug 31, 2026
somatic-mutation-accumulation
gap/no-mechanism
gap/needs-human-replication
gap/needs-replication
Aug 31, 2026
splicing-dysregulation
gap/needs-human-replication
gap/needs-replication
gap/no-mechanism
gap/dose-response-unclear
gap/no-fulltext-access
Aug 31, 2026
ubiquitin-proteasome-system
gap/unsourced
gap/no-fulltext-access
gap/needs-replication
gap/needs-human-replication
gap/no-mechanism
gap/dose-response-unclear
Aug 31, 2026
unfolded-protein-response
gap/needs-replication
gap/no-mechanism
gap/contradictory-evidence
gap/needs-human-replication
gap/long-term-unknown
Aug 31, 2026
vascular-calcification
gap/needs-human-replication
gap/contradictory-evidence
gap/needs-replication
gap/no-mechanism
gap/no-fulltext-access
Aug 31, 2026
wound-healing
gap/no-fulltext-access
gap/needs-human-replication
gap/no-mechanism
gap/needs-replication
gap/dose-response-unclear
stub
Aug 31, 2026
x-chromosome-inactivation
gap/needs-human-replication
gap/unsourced
gap/needs-replication
gap/contradictory-evidence
gap/no-mechanism
Aug 31, 2026
xenophagy
gap/needs-human-replication
gap/needs-replication
gap/unsourced
gap/no-mechanism
gap/long-term-unknown
gap/no-fulltext-access
Aug 31, 2026
pyroptosis
gap/unsourced
gap/needs-replication
gap/needs-human-replication
gap/contradictory-evidence
gap/no-mechanism
gap/dose-response-unclear
gap/no-fulltext-access
Aug 31, 2026
replicative-senescence
gap/unsourced
gap/needs-replication
gap/needs-human-replication
gap/dose-response-unclear
gap/no-mechanism
stub
gap/no-fulltext-access
Aug 31, 2026
reproductive-aging-tradeoffs
gap/contradictory-evidence
gap/no-mechanism
gap/needs-replication
gap/long-term-unknown
gap/unsourced
gap/no-fulltext-access
Aug 31, 2026
ribosome-biogenesis
gap/no-mechanism
Aug 31, 2026
sasp
gap/needs-replication
gap/unsourced
gap/needs-human-replication
gap/dose-response-unclear
gap/no-mechanism
Aug 31, 2026
senescence-escape
gap/needs-replication
gap/dose-response-unclear
gap/needs-human-replication
gap/no-mechanism
gap/long-term-unknown
gap/contradictory-evidence
gap/no-fulltext-access
Aug 31, 2026
senescence-immune-surveillance
gap/needs-replication
gap/needs-human-replication
gap/no-mechanism
gap/unsourced
gap/contradictory-evidence
gap/no-fulltext-access
gap/needs-fulltext-verification
Aug 31, 2026
mitochondrial-biogenesis
gap/unsourced
gap/needs-human-replication
gap/no-mechanism
gap/dose-response-unclear
Aug 31, 2026
mitochondrial-rna-leakage
gap/translation-blocked-safety
gap/preclinical-only
gap/needs-human-replication
gap/dose-response-unclear
gap/no-mechanism
gap/long-term-unknown
Aug 31, 2026
mitohormesis
gap/no-fulltext-access
gap/dose-response-unclear
gap/needs-human-replication
gap/needs-replication
Aug 31, 2026
mitophagy
gap/needs-replication
gap/needs-human-replication
gap/unsourced
gap/dose-response-unclear
gap/no-mechanism
gap/long-term-unknown
Aug 31, 2026
mtdna-heteroplasmy
gap/needs-replication
gap/needs-human-replication
gap/contradictory-evidence
gap/no-mechanism
gap/long-term-unknown
gap/unsourced
gap/dose-response-unclear
gap/needs-canonical-id
Aug 31, 2026
mtdna
gap/unsourced
gap/needs-replication
gap/needs-human-replication
gap/no-mechanism
gap/contradictory-evidence
gap/no-fulltext-access
Aug 31, 2026
oxphos
gap/contradictory-evidence
gap/no-mechanism
gap/needs-replication
gap/dose-response-unclear
gap/needs-human-replication
gap/long-term-unknown
Aug 31, 2026
partial-reprogramming
gap/needs-human-replication
gap/needs-replication
gap/long-term-unknown
gap/dose-response-unclear
gap/contradictory-evidence
Aug 31, 2026
pentosidine
gap/needs-canonical-id
gap/needs-replication
gap/no-fulltext-access
gap/no-mechanism
gap/needs-human-replication
Aug 31, 2026
glymphatic-system
gap/contradictory-evidence
gap/needs-human-replication
gap/needs-replication
gap/no-mechanism
gap/long-term-unknown
Aug 31, 2026
gut-barrier
gap/unsourced
gap/contradictory-evidence
gap/needs-replication
gap/no-mechanism
gap/needs-human-replication
Aug 31, 2026
histone-acetylation
gap/needs-replication
gap/no-fulltext-access
gap/needs-human-replication
gap/no-mechanism
gap/long-term-unknown
gap/dose-response-unclear
Aug 31, 2026
histone-modification
gap/needs-human-replication
gap/long-term-unknown
gap/no-mechanism
gap/no-fulltext-access
Aug 31, 2026
igg-fc-glycosylation
gap/no-mechanism
gap/needs-replication
gap/no-fulltext-access
Aug 31, 2026
lipofuscin
gap/no-fulltext-access
gap/no-mechanism
gap/needs-replication
gap/needs-human-replication
gap/contradictory-evidence
gap/dose-response-unclear
gap/unsourced
Aug 31, 2026
lipophagy
gap/needs-human-replication
gap/no-mechanism
gap/needs-replication
gap/unsourced
gap/no-fulltext-access
gap/dose-response-unclear
Aug 31, 2026
melanogenesis
gap/no-fulltext-access
gap/needs-replication
gap/no-mechanism
gap/needs-human-replication
gap/contradictory-evidence
Aug 31, 2026
microbial-amadori-deglycation
gap/needs-replication
gap/no-mechanism
gap/no-fulltext-access
Aug 31, 2026
apoptosis
gap/no-mechanism
gap/needs-replication
gap/needs-human-replication
Aug 31, 2026
autophagy
gap/unsourced
gap/needs-human-replication
gap/dose-response-unclear
Aug 31, 2026
carboxymethyl-lysine
gap/needs-human-replication
gap/contradictory-evidence
gap/needs-replication
gap/no-mechanism
Aug 31, 2026
chaperone-mediated-autophagy
gap/needs-replication
gap/needs-human-replication
gap/dose-response-unclear
gap/long-term-unknown
gap/no-mechanism
gap/needs-canonical-id
gap/no-fulltext-access
Aug 31, 2026
dna-demethylation
gap/needs-replication
gap/no-fulltext-access
gap/needs-canonical-id
gap/no-mechanism
gap/needs-human-replication
gap/dose-response-unclear
gap/stub
Aug 31, 2026
dna-methylation
gap/needs-replication
gap/needs-human-replication
gap/no-fulltext-access
gap/no-mechanism
gap/long-term-unknown
gap/contradictory-evidence
Aug 31, 2026
extracellular-matrix-remodeling
gap/needs-human-replication
gap/dose-response-unclear
gap/long-term-unknown
Aug 31, 2026
ferroptosis
gap/needs-human-replication
gap/no-mechanism
gap/dose-response-unclear
gap/contradictory-evidence
gap/needs-replication
stub
Aug 31, 2026
glucosepane
gap/needs-canonical-id
gap/needs-human-replication
gap/needs-replication
gap/no-mechanism
gap/no-fulltext-access
gap/contradictory-evidence
gap/needs-primary-source-verification
gap/dose-response-unclear
Aug 31, 2026
turner-syndrome
gap/needs-replication
gap/no-mechanism
gap/dose-response-unclear
gap/long-term-unknown
stub
gap/no-fulltext-access
Aug 31, 2026
type-2-diabetes
gap/needs-replication
gap/contradictory-evidence
gap/needs-human-replication
gap/no-fulltext-access
gap/long-term-unknown
gap/no-mechanism
gap/dose-response-unclear
Aug 31, 2026
vasomotor-symptoms
gap/unsourced
gap/no-mechanism
gap/needs-replication
gap/long-term-unknown
gap/no-fulltext-access
gap/contradictory-evidence
Aug 31, 2026
7-ketocholesterol
gap/no-fulltext-access
gap/needs-canonical-id
gap/needs-human-replication
gap/long-term-unknown
gap/dose-response-unclear
gap/needs-replication
Aug 31, 2026
adipogenesis
gap/needs-human-replication
gap/needs-replication
gap/no-mechanism
gap/unsourced
Aug 31, 2026
advanced-glycation-end-products
gap/needs-canonical-id
gap/needs-replication
gap/needs-human-replication
gap/no-mechanism
gap/contradictory-evidence
gap
gap/needs-primary-source-verification
Aug 31, 2026
allotopic-expression
gap/needs-replication
gap/needs-human-replication
gap/dose-response-unclear
gap/no-fulltext-access
Aug 31, 2026
progeria
gap/needs-canonical-id
gap/needs-replication
gap/needs-human-replication
gap/dose-response-unclear
gap/no-fulltext-access
gap/contradictory-evidence
gap/no-mechanism
gap/long-term-unknown
Aug 31, 2026
rosacea
gap/no-mechanism
gap/contradictory-evidence
gap/stub
gap/needs-replication
gap/long-term-unknown
gap/needs-canonical-id
gap/no-fulltext-access
Aug 31, 2026
sarcopenia
gap/needs-replication
gap/contradictory-evidence
gap/needs-human-replication
gap/unsourced
gap/no-fulltext-access
Aug 31, 2026
skin-aging
gap/needs-human-replication
gap/unsourced
gap/no-mechanism
gap/contradictory-evidence
gap/needs-replication
gap/no-fulltext-access
gap/long-term-unknown
gap/dose-response-unclear
gap/needs-pdf-verification
Aug 31, 2026
telangiectasia
gap/needs-replication
gap/no-mechanism
gap/contradictory-evidence
gap/unsourced
gap/long-term-unknown
gap/needs-human-replication
Aug 31, 2026
tooth-loss
gap/needs-replication
gap/contradictory-evidence
gap/needs-human-replication
gap/needs-canonical-id
gap/long-term-unknown
Aug 31, 2026
neurodegeneration
gap/needs-human-replication
gap/unsourced
gap/needs-replication
gap/no-mechanism
gap/contradictory-evidence
gap/long-term-unknown
stub
gap/no-fulltext-access
Aug 31, 2026
obesity
gap/needs-replication
gap/contradictory-evidence
gap/no-fulltext-access
gap/literature-checked-through-may-lag
gap/needs-human-replication
stub
Aug 31, 2026
osteoarthritis
gap/needs-replication
gap/needs-human-replication
gap/needs-mechanism
gap/no-mechanism
gap/contradictory-evidence
Aug 31, 2026
osteoporosis
gap/needs-human-replication
gap/needs-replication
gap/unsourced
Aug 31, 2026
parkinsons-disease
gap/unsourced
gap/contradictory-evidence
gap/needs-replication
gap/no-fulltext-access
gap/no-mechanism
gap/needs-human-replication
gap/long-term-unknown
Aug 31, 2026
periodontitis
gap/needs-replication
gap/no-mechanism
gap/contradictory-evidence
gap/needs-human-replication
gap/long-term-unknown
stub
gap/no-fulltext-access
Aug 31, 2026
polycystic-ovary-syndrome
gap/contradictory-evidence
gap/needs-updated-citation
gap/needs-replication
gap/no-mechanism
gap/no-data
gap/needs-canonical-id
gap/wrong-doi
Aug 31, 2026
premature-ovarian-insufficiency
gap/needs-human-replication
gap/needs-replication
gap/contradictory-evidence
gap/no-mechanism
gap/long-term-unknown
gap/no-fulltext-access
Aug 31, 2026
hypertension
gap/stub
gap/contradictory-evidence
gap/needs-replication
gap/no-mechanism
gap/no-fulltext-access
Aug 31, 2026
immunosenescence
gap/needs-replication
gap/needs-human-replication
gap/no-fulltext-access
gap/unsourced
gap/contradictory-evidence
gap/no-mechanism
gap/long-term-unknown
gap/needs-fulltext-verification
Aug 31, 2026
intervertebral-disc-degeneration
gap/needs-human-replication
gap/no-mechanism
gap/needs-replication
gap/unsourced
Aug 31, 2026
liver-fibrosis
gap/needs-replication
gap/needs-human-replication
gap/unsourced
gap/dose-response-unclear
gap/long-term-unknown
gap/no-fulltext-access
Aug 31, 2026
low-back-pain
gap/unsourced
gap/no-mechanism
gap/needs-human-replication
gap/needs-replication
gap/icd11-unverified
gap/no-fulltext-access
Aug 31, 2026
masld
gap/needs-canonical-id
gap/needs-replication
gap/needs-human-replication
gap/unsourced
gap/dose-response-unclear
gap/no-fulltext-access
Aug 31, 2026
menopause
gap/no-fulltext-access
gap/needs-verification
gap/needs-replication
gap/contradictory-evidence
gap/unsourced
stub
Aug 31, 2026
frailty
gap/no-fulltext-access
gap/needs-human-replication
gap/contradictory-evidence
gap/no-mechanism
gap/unsourced
gap/needs-replication
gap/long-term-unknown
Aug 31, 2026
genitourinary-syndrome-menopause
gap/needs-verification
gap/needs-replication
gap/long-term-unknown
gap/contradictory-evidence
Aug 31, 2026
gingival-recession
gap/needs-icd11-code
gap/needs-replication
gap/no-mechanism
gap/needs-quantitative-recession-rootcaries-risk
gap/no-fulltext-access
gap/dose-response-unclear
gap/needs-human-replication
Aug 31, 2026
hair-greying
gap/unsourced
gap/needs-replication
gap/needs-human-replication
gap/no-mechanism
gap/long-term-unknown
gap/no-fulltext-access
Aug 31, 2026
heart-failure
gap/needs-human-replication
gap/needs-replication
gap/long-term-unknown
gap/no-mechanism
gap/unsourced
gap/no-fulltext-access
Aug 31, 2026
hepatocellular-carcinoma
gap/needs-replication
gap/needs-human-replication
gap/unsourced
gap/long-term-unknown
Aug 31, 2026
hyperphosphatemia
gap/no-fulltext-access
gap/contradictory-evidence
gap/needs-human-replication
gap/needs-replication
gap/needs-canonical-id
gap/no-mechanism
Aug 31, 2026
chronic-venous-disease
gap/dose-response-unclear
gap/needs-replication
gap/long-term-unknown
gap/needs-human-replication
gap/needs-verification
gap/no-mechanism
gap/unsourced
gap/contradictory-evidence
gap/low-evidence-source
Aug 31, 2026
clonal-hematopoiesis
gap/dose-response-unclear
gap/needs-replication
gap/no-mechanism
gap/no-fulltext-access
gap/long-term-unknown
gap/needs-human-replication
Aug 31, 2026
copd
gap/needs-replication
gap/needs-human-replication
Aug 31, 2026
ear-nose-enlargement
gap/no-mechanism
gap/needs-replication
gap/contradictory-evidence
gap/no-fulltext-access
gap/unsourced
Aug 31, 2026
endometriosis
gap/needs-human-replication
gap/needs-replication
gap/no-mechanism
gap/unsourced
Aug 31, 2026
erythema
gap/needs-human-replication
gap/no-mechanism
gap/dose-response-unclear
gap/needs-replication
Aug 31, 2026
familial-hypercholesterolemia
gap/needs-replication
gap/needs-human-replication
gap/long-term-unknown
gap/no-mechanism
Aug 31, 2026
arterial-stiffening
gap/needs-human-replication
gap/no-mechanism
gap/dose-response-unclear
gap/needs-replication
gap/needs-canonical-id
gap/unsourced
Aug 31, 2026
atherosclerosis
gap/needs-human-replication
gap/unsourced
gap/no-mechanism
gap/needs-replication
gap/long-term-unknown
gap/no-fulltext-access
Aug 31, 2026
cancer
gap/unsourced
gap/needs-human-replication
gap/needs-replication
gap/no-fulltext-access
gap/needs-aged-host-validation
gap/no-mechanism
gap/contradictory-evidence
gap/long-term-unknown
gap/needs-full-extraction
Aug 31, 2026
cardiac-fibrosis
gap/no-mechanism
gap/needs-human-replication
gap/dose-response-unclear
gap/long-term-unknown
gap/needs-replication
gap/contradictory-evidence
gap/no-fulltext-access
Aug 31, 2026
cardiovascular-aging
gap/needs-replication
gap/unsourced
gap/dose-response-unclear
gap/needs-human-replication
gap/contradictory-evidence
gap/no-mechanism
gap/no-fulltext-access
Aug 31, 2026
cherry-angioma
gap/no-mechanism
gap/unsourced
gap/needs-replication
gap/needs-canonical-id
gap/no-fulltext-access
Aug 31, 2026
chronic-kidney-disease
gap/contradictory-evidence
gap/stub
gap/dose-response-unclear
gap/needs-human-replication
gap/no-mechanism
gap/needs-replication
Aug 31, 2026
age-related-cataract
gap/contradictory-evidence
gap/needs-human-replication
gap/needs-replication
gap/no-fulltext-access
Aug 31, 2026
age-related-cholestasis
gap/needs-human-replication
gap/no-mechanism
gap/dose-response-unclear
gap/contradictory-evidence
gap/no-fulltext-access
Aug 31, 2026
age-related-female-infertility
gap/needs-replication
gap/needs-human-replication
gap/long-term-unknown
Aug 31, 2026
alzheimers-disease
gap/contradictory-evidence
gap/needs-replication
gap/long-term-unknown
gap/needs-human-replication
gap/dose-response-unclear
gap/no-mechanism
gap/no-fulltext-access
Aug 31, 2026
androgenetic-alopecia
gap/contradictory-evidence
gap/needs-replication
gap/long-term-unknown
gap/no-mechanism
gap/unsourced
gap/needs-human-replication
gap/no-fulltext-access
Aug 31, 2026
andropause
gap/needs-verification
gap/needs-replication
gap/contradictory-evidence
gap/long-term-unknown
Aug 31, 2026
anemia-of-aging
gap/unsourced
gap/no-mechanism
gap/needs-human-replication
gap/contradictory-evidence
gap/needs-replication
gap/no-fulltext-access
Aug 31, 2026
telomerase-pathway
gap/needs-replication
gap/unsourced
gap/no-mechanism
gap/dose-response-unclear
gap/needs-human-replication
gap/needs-canonical-id
gap/no-fulltext-access
Aug 31, 2026
tgf-beta
gap/needs-human-replication
gap/needs-replication
gap/contradictory-evidence
gap/no-mechanism
gap/unsourced
gap/dose-response-unclear
gap/long-term-unknown
Aug 31, 2026
tlr3-trif-pathway
gap/contradictory-evidence
gap/needs-human-replication
gap/no-mechanism
gap/needs-replication
gap/dose-response-unclear
gap/unsourced
Aug 31, 2026
trkb-pathway
gap/no-fulltext-access
gap/needs-replication
gap/needs-human-replication
gap/contradictory-evidence
gap/no-mechanism
gap/needs-canonical-id
Aug 31, 2026
type-i-interferon-signaling
gap/needs-replication
gap/no-mechanism
gap/needs-human-replication
gap/dose-response-unclear
gap/no-fulltext-access
gap/needs-full-extraction
Aug 31, 2026
vitamin-k-cycle
gap/needs-human-replication
gap/no-mechanism
gap/contradictory-evidence
gap/needs-canonical-id
gap/no-fulltext-access
Aug 31, 2026
wnt-beta-catenin
gap/unsourced
gap/needs-replication
gap/no-fulltext-access
gap/needs-human-replication
gap/contradictory-evidence
gap/no-mechanism
gap/dose-response-unclear
Aug 31, 2026
p53-pathway
gap/unsourced
gap/no-mechanism
gap/needs-replication
gap/contradictory-evidence
gap/needs-human-replication
Aug 31, 2026
pi3k-akt-pathway
gap/needs-canonical-id
gap/needs-replication
gap/dose-response-unclear
gap/long-term-unknown
Aug 31, 2026
pink1-parkin-pathway
gap/contradictory-evidence
gap/no-mechanism
gap/needs-human-replication
gap/needs-replication
gap/long-term-unknown
gap/no-fulltext-access
Aug 31, 2026
pomc-processing
gap/no-mechanism
gap/needs-replication
gap/needs-human-replication
gap/unsourced
gap/needs-canonical-id
gap/no-fulltext-access
Aug 31, 2026
ras-mapk
gap/needs-replication
gap/needs-human-replication
gap/dose-response-unclear
gap/unsourced
gap/needs-canonical-id
Aug 31, 2026
rig-i-mavs-pathway
gap/unsourced
gap/needs-replication
gap/no-mechanism
gap/long-term-unknown
gap/needs-canonical-id
gap/dose-response-unclear
Aug 31, 2026
scfa-signaling
gap/unsourced
gap/needs-human-replication
gap/dose-response-unclear
gap/contradictory-evidence
gap/no-mechanism
gap/long-term-unknown
gap/no-fulltext-access
Aug 31, 2026
sirtuin
gap/no-fulltext-access
gap/needs-replication
gap/unsourced
gap/needs-human-replication
gap/long-term-unknown
gap/dose-response-unclear
gap/contradictory-evidence
gap/needs-canonical-id
Aug 31, 2026
spm-pathway
gap/no-mechanism
gap/needs-replication
gap/needs-human-replication
gap/contradictory-evidence
gap/dose-response-unclear
gap/needs-canonical-id
gap/no-fulltext-access
Aug 31, 2026
mitochondrial-dynamics
gap/needs-canonical-id
gap/contradictory-evidence
gap/needs-replication
gap/no-mechanism
gap/dose-response-unclear
gap/long-term-unknown
gap/no-fulltext-access
Aug 31, 2026
mtor
gap/needs-replication
gap/unsourced
gap/no-fulltext-access
gap/dose-response-unclear
gap/long-term-unknown
Aug 31, 2026
neurotrophin-signaling
gap/needs-human-replication
gap/needs-replication
gap/no-mechanism
gap/dose-response-unclear
gap/long-term-unknown
gap/needs-canonical-id
gap/no-fulltext-access
Aug 31, 2026
nf-kb
gap/unsourced
gap/needs-human-replication
gap/dose-response-unclear
gap/needs-replication
gap/no-fulltext-access
Aug 31, 2026
nlrp3-inflammasome
gap/needs-human-replication
gap/unsourced
gap/no-mechanism
gap/dose-response-unclear
gap/long-term-unknown
gap/needs-replication
gap/needs-verification
Aug 31, 2026
non-homologous-end-joining
gap/no-fulltext-access
gap/unsourced
gap/needs-replication
gap/needs-human-replication
gap/dose-response-unclear
gap/long-term-unknown
Aug 31, 2026
notch-pathway
gap/no-mechanism
gap/unsourced
gap/needs-replication
gap/needs-human-replication
gap/dose-response-unclear
gap/long-term-unknown
gap/needs-canonical-id
Aug 31, 2026
nucleotide-excision-repair
gap/needs-replication
gap/needs-human-replication
gap/no-mechanism
Aug 31, 2026
p16-rb-pathway
gap/unsourced
gap/no-fulltext-access
gap/no-mechanism
gap/needs-human-replication
gap/long-term-unknown
gap/needs-canonical-id
Aug 31, 2026
il-11-signaling
gap/contradictory-evidence
gap/no-mechanism
gap/dose-response-unclear
gap/long-term-unknown
gap/needs-human-replication
Aug 31, 2026
insulin-igf1
gap/needs-replication
gap/no-fulltext-access
gap/needs-human-replication
gap/contradictory-evidence
gap/no-mechanism
Aug 31, 2026
integrated-stress-response
gap/needs-human-replication
gap/needs-replication
gap/long-term-unknown
gap/no-mechanism
gap/unsourced
Aug 31, 2026
jak-stat-pathway
gap/needs-replication
gap/needs-human-replication
gap/no-mechanism
gap/unsourced
gap/long-term-unknown
gap/contradictory-evidence
gap/needs-canonical-id
Aug 31, 2026
lipoprotein-metabolism
gap/needs-replication
gap/long-term-unknown
gap/needs-human-replication
gap/no-mechanism
Aug 31, 2026
lps-tlr4-nfkb
gap/needs-replication
gap/unsourced
gap/no-mechanism
gap/contradictory-evidence
gap/needs-human-replication
gap/long-term-unknown
Aug 31, 2026
melanocortin-system
gap/needs-canonical-id
gap/needs-human-replication
gap/stub
Aug 31, 2026
mevalonate-pathway
gap/dose-response-unclear
gap/needs-replication
gap/contradictory-evidence
gap/no-mechanism
gap/needs-human-replication
gap/long-term-unknown
Aug 31, 2026
mismatch-repair
gap/needs-replication
gap/unsourced
gap/no-mechanism
gap/contradictory-evidence
gap/no-fulltext-access
Aug 31, 2026
dna-damage-response
gap/no-fulltext-access
gap/needs-replication
gap/needs-human-replication
gap/long-term-unknown
gap/no-mechanism
gap/contradictory-evidence
stub
Aug 31, 2026
fgf-signaling
gap/needs-canonical-id
gap/no-mechanism
gap/no-fulltext-access
gap/needs-human-replication
gap/needs-replication
gap/contradictory-evidence
gap/unsourced
Aug 31, 2026
heat-shock-response
gap/no-fulltext-access
gap/needs-canonical-id
gap/no-mechanism
gap/contradictory-evidence
gap/needs-human-replication
gap/needs-replication
gap/long-term-unknown
Aug 31, 2026
hedgehog-pathway
gap/needs-human-replication
gap/unsourced
gap/needs-replication
gap/needs-canonical-id
gap/long-term-unknown
Aug 31, 2026
hippo-yap-taz
gap/needs-human-replication
gap/needs-replication
gap/no-mechanism
gap/dose-response-unclear
gap/long-term-unknown
gap/unsourced
gap/needs-canonical-id
gap/no-fulltext-access
Aug 31, 2026
homologous-recombination
gap/no-fulltext-access
gap/needs-replication
gap/needs-human-replication
gap/long-term-unknown
gap/no-mechanism
gap/unsourced
Aug 31, 2026
hpa-axis
gap/needs-canonical-id
gap/contradictory-evidence
gap/needs-human-replication
gap/stub
Aug 31, 2026
il-1-signaling
gap/needs-canonical-id
gap/needs-replication
gap/needs-human-replication
Aug 31, 2026
apoptosis-pathway
gap/needs-human-replication
gap/needs-replication
gap/dose-response-unclear
gap/needs-canonical-id
gap/no-fulltext-access
Aug 31, 2026
base-excision-repair
gap/needs-replication
gap/needs-human-replication
gap/no-mechanism
gap/long-term-unknown
gap/dose-response-unclear
gap/no-fulltext-access
Aug 31, 2026
bcl-2-family-signaling
gap/contradictory-evidence
gap/unsourced
gap/needs-replication
gap/no-mechanism
gap/needs-human-replication
gap/no-fulltext-access
Aug 31, 2026
bmp-signaling
gap/needs-human-replication
gap/no-mechanism
gap/needs-replication
gap/dose-response-unclear
gap/long-term-unknown
gap/unsourced
gap/needs-canonical-id
Aug 31, 2026
camp-signaling
gap/needs-canonical-id
gap/needs-replication
gap/needs-human-replication
gap/no-mechanism
gap/contradictory-evidence
gap/unsourced
gap/dose-response-unclear
gap/unverified-source
Aug 31, 2026
cgas-sting
gap/no-fulltext-access
gap/unsourced
gap/needs-human-replication
gap/needs-replication
gap/no-mechanism
gap/long-term-unknown
gap/needs-canonical-id
Aug 31, 2026
cholinergic-anti-inflammatory-pathway
gap/needs-human-replication
gap/needs-replication
gap/no-mechanism
gap/contradictory-evidence
gap/dose-response-unclear
gap/needs-canonical-id
gap/no-fulltext-access
Aug 31, 2026
cxcl12-cxcr4-pathway
gap/contradictory-evidence
gap/needs-human-replication
gap/no-mechanism
gap/needs-replication
Aug 31, 2026
xpf
gap/needs-replication
gap/no-mechanism
gap/needs-human-replication
gap/needs-canonical-id
Aug 31, 2026
xrcc1
gap/needs-canonical-id
gap/needs-replication
gap/needs-human-replication
gap/no-mechanism
gap/unsourced
Aug 31, 2026
yap-taz
gap/needs-replication
gap/contradictory-evidence
gap/no-mechanism
gap/dose-response-unclear
gap/long-term-unknown
stub
gap/needs-human-replication
gap/needs-canonical-id
gap/unsourced
gap/no-fulltext-access
Aug 31, 2026
yme1l
gap/needs-replication
gap/unsourced
gap/needs-human-replication
gap/needs-canonical-id
gap/no-fulltext-access
Aug 31, 2026
ampk
gap/needs-replication
gap/needs-human-replication
gap/long-term-unknown
gap/dose-response-unclear
gap/contradictory-evidence
gap/no-mechanism
Aug 31, 2026
ulk1
gap/needs-canonical-id
gap/unsourced
gap/no-mechanism
gap/needs-replication
gap/no-fulltext-access
gap/needs-human-replication
gap/long-term-unknown
Aug 31, 2026
vcp
gap/needs-human-replication
gap/no-mechanism
gap/needs-replication
gap/unsourced
Aug 31, 2026
vdac1
gap/contradictory-evidence
gap/unsourced
gap/needs-replication
gap/needs-human-replication
gap/dose-response-unclear
gap/no-mechanism
gap/needs-canonical-id
gap/no-fulltext-access
Aug 31, 2026
vegfr2
gap/needs-human-replication
gap/no-mechanism
gap/needs-replication
Aug 31, 2026
vkorc1
gap/needs-replication
gap/needs-human-replication
gap/no-fulltext-access
gap/needs-gtex-aging-correlation
gap/no-mechanism
Aug 31, 2026
vsig4
gap/needs-genage-check
gap/no-mechanism
gap/needs-clinical-trials-recheck
gap/needs-gtex-age-stratified
gap/needs-sex-stratified-data
gap/mr-not-attempted
gap/needs-human-replication
Aug 31, 2026
xiap
gap/needs-canonical-id
gap/unsourced
gap/needs-replication
gap/needs-human-replication
gap/no-fulltext-access
gap/long-term-unknown
Aug 31, 2026
xist
gap/needs-canonical-id
gap/no-mechanism
gap/needs-replication
Aug 31, 2026
tpp1
gap/needs-canonical-id
gap/dose-response-unclear
gap/needs-replication
gap/needs-human-replication
gap/no-mechanism
Aug 31, 2026
traf6
gap/needs-replication
gap/needs-human-replication
gap/contradictory-evidence
gap/no-mechanism
gap/needs-canonical-id
Aug 31, 2026
trem2
gap/needs-replication
gap/contradictory-evidence
gap/unsourced
gap/long-term-unknown
gap/needs-human-replication
gap/dose-response-unclear
Aug 31, 2026
trf1
gap/needs-human-replication
gap/contradictory-evidence
gap/needs-replication
gap/not-tested
gap/not-queried
gap/no-fulltext-access
Aug 31, 2026
trf2
gap/no-mechanism
gap/needs-replication
gap/unsourced
gap/needs-human-replication
Aug 31, 2026
trim41
gap/needs-canonical-id
gap/no-mechanism
gap/needs-human-replication
gap/no-fulltext-access
gap/needs-replication
gap/unsourced
Aug 31, 2026
tsc1-tsc2
gap/needs-replication
gap/unsourced
gap/no-mechanism
gap/needs-human-replication
Aug 31, 2026
tyk2
gap/needs-human-replication
gap/unsourced
gap/needs-replication
gap/long-term-unknown
gap/no-mechanism
gap/no-fulltext-access
Aug 31, 2026
tyrosine-hydroxylase
gap/unsourced
gap/needs-replication
gap/needs-human-replication
gap/no-mechanism
gap/long-term-unknown
Aug 31, 2026
tert
gap/no-fulltext-access
gap/needs-replication
gap/unsourced
gap/needs-human-replication
gap/long-term-unknown
gap/no-mechanism
Aug 31, 2026
tet1
gap/needs-replication
gap/needs-human-replication
gap/no-mechanism
gap/long-term-unknown
gap/needs-canonical-id
Aug 31, 2026
tet2
gap/needs-replication
gap/unsourced
gap/no-mechanism
gap/no-fulltext-access
gap/needs-human-replication
Aug 31, 2026
tet3
gap/needs-replication
gap/no-mechanism
gap/needs-human-replication
gap/needs-canonical-id
Aug 31, 2026
tfam
gap/needs-human-replication
gap/needs-replication
gap/dose-response-unclear
gap/unsourced
gap/no-mechanism
gap/needs-canonical-id
Aug 31, 2026
tfeb
gap/unsourced
gap/no-fulltext-access
gap/dose-response-unclear
gap/no-mechanism
gap/needs-human-replication
gap/needs-canonical-id
Aug 31, 2026
timp-1
gap/needs-replication
gap/needs-human-replication
Aug 31, 2026
tin2
gap/needs-canonical-id
gap/no-mechanism
gap/needs-replication
gap/not-queried
Aug 31, 2026
tmsb4x
gap/needs-canonical-id
gap/no-gtex-aging-signal
gap/dose-response-unclear
gap/needs-human-replication
gap/no-fulltext-access
Aug 31, 2026
st6gal1
gap/no-fulltext-access
gap/needs-replication
gap/no-mechanism
Aug 31, 2026
stat1
gap/needs-replication
gap/needs-human-replication
gap/unsourced
gap/no-mechanism
gap/contradictory-evidence
gap/dose-response-unclear
gap/no-fulltext-access
Aug 31, 2026
stat2
gap/needs-replication
gap/needs-human-replication
Aug 31, 2026
stat3
gap/no-mechanism
gap/long-term-unknown
gap/needs-human-replication
gap/needs-gtex-aging-correlation
Aug 31, 2026
sting
gap/needs-canonical-id
gap/needs-replication
gap/unsourced
gap/needs-human-replication
gap/not-queried
gap/long-term-unknown
gap/no-fulltext-access
Aug 31, 2026
tak1
gap/needs-replication
gap/no-mechanism
gap/unsourced
gap/needs-human-replication
gap/long-term-unknown
gap/needs-population-data
gap/needs-canonical-id
Aug 31, 2026
tau
gap/needs-replication
gap/unsourced
gap/contradictory-evidence
gap/no-fulltext-access
gap/needs-human-replication
gap/long-term-unknown
gap/no-mechanism
Aug 31, 2026
tbk1
gap/no-fulltext-access
gap/needs-replication
gap/needs-human-replication
gap/dose-response-unclear
gap/long-term-unknown
gap/contradictory-evidence
gap/no-mechanism
gap/unsourced
Aug 31, 2026
terc
gap/no-uniprot-noncoding-rna
gap/needs-replication
gap/long-term-unknown
gap/unsourced
gap/no-mechanism
gap/no-fulltext-access
Aug 31, 2026
slc7a11
gap/needs-human-replication
gap/no-fulltext-access
gap/contradictory-evidence
gap/needs-replication
gap/dose-response-unclear
gap/not-populated
Aug 31, 2026
smac-diablo
gap/needs-replication
gap/no-fulltext-access
gap/needs-human-replication
gap/no-mechanism
Aug 31, 2026
smad2-smad3
gap/needs-human-replication
gap/needs-replication
gap/unsourced
gap/contradictory-evidence
gap/needs-canonical-id
gap/no-mechanism
gap/no-opentargets-entry
Aug 31, 2026
sod2
gap/needs-replication
gap/no-fulltext-access
gap/contradictory-evidence
gap/no-mechanism
Aug 31, 2026
sost
gap/needs-replication
gap/needs-human-replication
gap/no-mechanism
gap/contradictory-evidence
gap/no-fulltext-access
Aug 31, 2026
sox2
gap/no-fulltext-access
gap/no-mechanism
gap/contradictory-evidence
gap/needs-replication
gap/unsourced
gap/needs-human-replication
Aug 31, 2026
sparc
gap/needs-human-replication
gap/no-mechanism
gap/needs-gtex-age-stratified
gap/contradictory-evidence
Aug 31, 2026
spry1
gap/no-mechanism
gap/contradictory-evidence
gap/needs-replication
gap/no-opentargets-entry
gap/long-term-unknown
gap/needs-human-replication
gap/needs-tissue-expression-data
Aug 31, 2026
srebp-2
gap/needs-replication
gap/no-mechanism
Aug 31, 2026
sf3b1
gap/needs-canonical-id
gap/needs-replication
gap/unsourced
gap/no-mechanism
gap/no-fulltext-access
Aug 31, 2026
sgk1
gap/needs-replication
gap/needs-human-replication
gap/no-mechanism
gap/long-term-unknown
gap/no-fulltext-access
Aug 31, 2026
shelterin
gap/no-fulltext-access
gap/needs-replication
gap/no-mechanism
gap/unsourced
gap/needs-human-replication
gap/contradictory-evidence
gap/needs-canonical-id
Aug 31, 2026
sirt1
gap/unsourced
gap/needs-human-replication
gap/contradictory-evidence
gap/needs-replication
gap/no-fulltext-access
Aug 31, 2026
sirt2
gap/unsourced
gap/no-mechanism
gap/needs-human-replication
gap/needs-replication
gap/no-fulltext-access
gap/contradictory-evidence
Aug 31, 2026
sirt3
gap/needs-human-replication
gap/needs-replication
gap/dose-response-unclear
gap/no-mechanism
gap/needs-canonical-id
gap/no-opentargets-entry
Aug 31, 2026
sirt6
gap/needs-human-replication
gap/needs-replication
gap/no-mechanism
gap/contradictory-evidence
gap/dose-response-unclear
gap/long-term-unknown
Aug 31, 2026
sirt7
gap/needs-replication
gap/needs-human-replication
gap/dose-response-unclear
gap/long-term-unknown
gap/no-mechanism
gap/needs-canonical-id
Aug 31, 2026
puma
gap/no-fulltext-access
gap/no-mechanism
gap/needs-replication
gap/contradictory-evidence
gap/unsourced
gap/needs-human-replication
gap/dose-response-unclear
Aug 31, 2026
rad50
gap/needs-replication
gap/no-mechanism
gap/needs-human-replication
gap/no-fulltext-access
Aug 31, 2026
rage
gap/needs-replication
gap/needs-human-replication
Aug 31, 2026
raptor
gap/needs-replication
gap/needs-human-replication
gap/unsourced
Aug 31, 2026
rictor
gap/needs-replication
gap/no-mechanism
gap/needs-human-replication
gap/long-term-unknown
gap/dose-response-unclear
Aug 31, 2026
rpa
gap/needs-replication
gap/no-mechanism
gap/needs-human-replication
gap/no-fulltext-access
Aug 31, 2026
runx2
gap/needs-human-replication
gap/needs-replication
Aug 31, 2026
s100a8-s100a9
gap/needs-canonical-id
gap/needs-replication
gap/unsourced
gap/needs-human-replication
gap/no-fulltext-access
gap/dose-response-unclear
gap/no-mechanism
Aug 31, 2026
s6k1
gap/unsourced
gap/contradictory-evidence
gap/no-fulltext-access
gap/no-mechanism
gap/needs-replication
gap/needs-human-replication
Aug 31, 2026
pgc-1alpha
gap/needs-human-replication
gap/unsourced
gap/needs-replication
gap/no-fulltext-access
gap/contradictory-evidence
gap/no-mechanism
Aug 31, 2026
pi3k
gap/needs-canonical-id
gap/needs-replication
gap/needs-human-replication
gap/unsourced
gap/no-mechanism
Aug 31, 2026
pink1
gap/contradictory-evidence
gap/no-fulltext-access
gap/needs-human-replication
gap/needs-replication
gap/no-mechanism
gap/unsourced
gap/needs-canonical-id
Aug 31, 2026
polb
gap/unsourced
gap/needs-human-replication
gap/needs-replication
gap/no-mechanism
gap/no-fulltext-access
Aug 31, 2026
polg
gap/unsourced
gap/needs-human-replication
gap/contradictory-evidence
gap/needs-replication
gap/no-mechanism
gap/needs-canonical-id
Aug 31, 2026
pomc
gap/needs-canonical-id
gap/needs-human-replication
gap/no-mechanism
gap/needs-replication
stub
gap/needs-tissue-expression-data
gap/contradictory-evidence
gap/no-fulltext-access
Aug 31, 2026
pot1
gap/needs-replication
gap/no-fulltext-access
gap/needs-human-replication
gap/unsourced
gap/needs-canonical-id
Aug 31, 2026
prox1
gap/needs-canonical-id
gap/needs-replication
gap/needs-human-replication
gap/unsourced
gap/no-opentargets-entry
gap/no-mechanism
Aug 31, 2026
pten
gap/unsourced
gap/needs-replication
gap/needs-human-replication
gap/no-mechanism
Aug 31, 2026
p62
gap/needs-canonical-id
gap/no-mechanism
gap/needs-replication
gap/needs-human-replication
gap/contradictory-evidence
gap/no-fulltext-access
Aug 31, 2026
pai-1
gap/no-mechanism
gap/needs-replication
gap/needs-human-replication
gap/dose-response-unclear
gap/long-term-unknown
Aug 31, 2026
palb2
gap/needs-canonical-id
gap/no-mechanism
gap/needs-replication
gap/contradictory-evidence
gap/needs-human-replication
Aug 31, 2026
parkin
gap/needs-canonical-id
gap/no-fulltext-access
gap/needs-replication
gap/no-mechanism
gap/needs-human-replication
gap/long-term-unknown
Aug 31, 2026
parp1
gap/needs-replication
gap/needs-human-replication
gap/no-mechanism
gap/unsourced
gap/contradictory-evidence
gap/no-fulltext-access
Aug 31, 2026
pcna
gap/needs-canonical-id
gap/needs-replication
gap/no-fulltext-access
gap/needs-human-replication
gap/no-mechanism
Aug 31, 2026
pcsk9
gap/no-mechanism
gap/needs-replication
gap/needs-human-replication
gap/long-term-unknown
gap/no-fulltext-access
Aug 31, 2026
pdk1
gap/no-fulltext-access
gap/needs-replication
gap/needs-human-replication
gap/unsourced
gap/no-mechanism
gap/long-term-unknown
Aug 31, 2026
perk
gap/no-mechanism
gap/needs-human-replication
gap/contradictory-evidence
gap/long-term-unknown
Aug 31, 2026
ogg1
gap/needs-canonical-id
gap/needs-replication
gap/needs-human-replication
gap/long-term-unknown
gap/unsourced
gap/no-mechanism
Aug 31, 2026
oma1
gap/unsourced
gap/needs-replication
gap/no-mechanism
gap/needs-human-replication
gap/contradictory-evidence
gap/long-term-unknown
stub
gap/no-fulltext-access
Aug 31, 2026
opa1
gap/needs-human-replication
gap/needs-replication
gap/no-mechanism
gap/long-term-unknown
gap/needs-canonical-id
Aug 31, 2026
optn
gap/no-fulltext-access
gap/needs-replication
gap/needs-human-replication
gap/no-mechanism
gap/unsourced
gap/needs-canonical-id
gap/contradictory-evidence
Aug 31, 2026
osteopontin
gap/needs-replication
gap/dose-response-unclear
gap/needs-human-replication
gap/no-mechanism
Aug 31, 2026
p16
gap/needs-human-replication
gap/needs-replication
gap/long-term-unknown
gap/unsourced
gap/needs-canonical-id
gap/no-fulltext-access
Aug 31, 2026
p21
gap/needs-replication
gap/no-mechanism
gap/unsourced
gap/needs-human-replication
gap/dose-response-unclear
gap/no-fulltext-access
Aug 31, 2026
p53
gap/unsourced
gap/needs-human-replication
Aug 31, 2026
noxa
gap/needs-canonical-id
gap/unsourced
gap/needs-primary-citation-for-human-p53re-coordinates
gap/no-fulltext-access
gap/needs-human-replication
gap/no-mechanism
gap/needs-replication
Aug 31, 2026
nr3c1
gap/no-fulltext-access
gap/needs-human-replication
gap/dose-response-unclear
gap/long-term-unknown
gap/needs-replication
Aug 31, 2026
nr3c2
gap/needs-canonical-id
gap/needs-replication
gap/long-term-unknown
Aug 31, 2026
nrep
gap/needs-genage-check
gap/needs-human-replication
gap/needs-extended-data-verification
gap/no-druggable-probe
gap/no-mechanism
gap/needs-gtex-age-stratified
gap/contradictory-evidence
gap/no-fulltext-access
Aug 31, 2026
nrf1
gap/needs-canonical-id
gap/needs-replication
gap/no-fulltext-access
gap/needs-human-replication
gap/no-mechanism
Aug 31, 2026
nrf2
gap/needs-replication
gap/needs-human-replication
gap/long-term-unknown
gap/not-populated
gap/contradictory-evidence
gap/dose-response-unclear
gap/no-fulltext-access
Aug 31, 2026
oct4
gap/unsourced
gap/needs-human-replication
gap/no-mechanism
gap/long-term-unknown
gap/dose-response-unclear
gap/needs-replication
Aug 31, 2026
mtp
gap/no-mechanism
gap/unsourced
gap/long-term-unknown
gap/no-fulltext-access
gap/needs-canonical-id
Aug 31, 2026
mutyh
gap/unsourced
gap/needs-human-replication
gap/no-fulltext-access
gap/needs-replication
gap/contradictory-evidence
gap/no-opentargets-entry
Aug 31, 2026
myd88
gap/needs-replication
gap/needs-human-replication
gap/no-mechanism
gap/needs-data
Aug 31, 2026
myostatin
gap/dose-response-unclear
gap/needs-replication
gap/needs-human-replication
gap/unsourced
gap/no-mechanism
gap/no-fulltext-access
Aug 31, 2026
nampt
gap/needs-human-replication
gap/needs-replication
gap/unsourced
gap/dose-response-unclear
gap/stub
gap/contradictory-evidence
gap/no-mechanism
gap/long-term-unknown
Aug 31, 2026
nanog
gap/unsourced
gap/no-mechanism
gap/needs-human-replication
gap/needs-replication
gap/needs-canonical-id
Aug 31, 2026
ndp52
gap/no-fulltext-access
gap/needs-replication
gap/needs-human-replication
gap/no-mechanism
gap/unsourced
gap/needs-canonical-id
Aug 31, 2026
nefl
gap/needs-replication
gap/no-fulltext-access
gap/needs-human-replication
gap/needs-tissue-expression-data
gap/no-mechanism
gap/not-tested-mr
gap/needs-canonical-id
Aug 31, 2026
nix
gap/needs-canonical-id
gap/no-mechanism
gap/needs-human-replication
gap/unsourced
gap/needs-replication
gap/no-fulltext-access
Aug 31, 2026
mlh1
gap/no-mechanism
gap/unsourced
gap/needs-human-replication
gap/needs-replication
gap/not-checked
gap/no-fulltext-access
Aug 31, 2026
mmp-1
gap/no-mechanism
gap/needs-replication
gap/long-term-unknown
gap/needs-human-replication
gap/unsourced
Aug 31, 2026
mmp-3
gap/needs-replication
gap/unsourced
gap/no-mechanism
gap/needs-human-replication
gap/contradictory-evidence
Aug 31, 2026
mmp-9
gap/needs-replication
gap/no-mechanism
gap/contradictory-evidence
gap/long-term-unknown
gap/needs-human-replication
gap/needs-canonical-id
Aug 31, 2026
monoamine-oxidase
gap/needs-human-replication
gap/contradictory-evidence
gap/needs-replication
Aug 31, 2026
mots-c-peptide
gap/no-mechanism
gap/needs-replication
gap/contradictory-evidence
gap/unsourced
gap/needs-canonical-id
gap/needs-human-replication
Aug 31, 2026
mrn-complex
gap/needs-human-replication
gap/needs-replication
gap/no-mechanism
gap/no-fulltext-access
gap/needs-mechanism-clarity
gap/unsourced
Aug 31, 2026
msh2
gap/needs-canonical-id
gap/needs-human-replication
gap/needs-replication
gap/no-mechanism
gap/unsourced
gap/no-fulltext-access
Aug 31, 2026
mcl-1
gap/unsourced
gap/needs-canonical-id
gap/needs-human-replication
gap/needs-replication
gap/dose-response-unclear
gap/no-mechanism
gap/long-term-unknown
gap/contradictory-evidence
gap/no-fulltext-access
Aug 31, 2026
mdm2
gap/needs-replication
gap/needs-human-replication
gap/dose-response-unclear
gap/unsourced
gap/no-mechanism
Aug 31, 2026
mff
gap/needs-replication
gap/no-fulltext-access
gap/needs-human-replication
gap/no-mechanism
gap/long-term-unknown
Aug 31, 2026
mgat3
gap/needs-replication
gap/no-mechanism
gap/no-fulltext-access
Aug 31, 2026
mid49
gap/needs-replication
gap/no-mechanism
gap/needs-human-replication
gap/no-fulltext-access
Aug 31, 2026
mid51
gap/needs-replication
gap/no-mechanism
gap/needs-human-replication
gap/no-fulltext-access
gap/dose-response-unclear
Aug 31, 2026
miro1
gap/unsourced
gap/needs-human-replication
gap/no-mechanism
gap/needs-replication
gap/needs-canonical-id
gap/long-term-unknown
gap/no-fulltext-access
Aug 31, 2026
miro2
gap/unsourced
gap/no-mechanism
gap/needs-human-replication
gap/needs-replication
gap/long-term-unknown
gap/needs-canonical-id
Aug 31, 2026
mitofusins
gap/needs-replication
gap/unsourced
gap/needs-human-replication
gap/no-mechanism
gap/no-fulltext-access
Aug 31, 2026
lpl
gap/needs-canonical-id
gap/contradictory-evidence
gap/needs-replication
gap/long-term-unknown
Aug 31, 2026
lrp5-lrp6
gap/no-mechanism
gap/needs-replication
gap/contradictory-evidence
gap/needs-human-replication
gap/needs-gtex-lookup
gap/needs-canonical-id
gap/needs-mouse-ortholog
Aug 31, 2026
lyve1
gap/no-mechanism
gap/needs-human-replication
Aug 31, 2026
matrix-gla-protein
gap/unsourced
gap/needs-longitudinal-aging-trajectory
gap/contradictory-evidence
gap/needs-gtex-aging-correlation
gap/needs-human-replication
Aug 31, 2026
mavs
gap/needs-replication
gap/contradictory-evidence
gap/no-mechanism
Aug 31, 2026
mc1r
gap/dose-response-unclear
gap/needs-population-evidence
gap/contradictory-evidence
gap/needs-human-replication
gap/no-fulltext-access
Aug 31, 2026
mc3r
gap/needs-gtex-subregion-data
gap/needs-replication
gap/no-mechanism
gap/needs-human-replication
gap/stub
Aug 31, 2026
mc4r
gap/needs-replication
gap/no-fulltext-access
gap/needs-human-replication
gap/unsourced
gap/no-mechanism
gap/needs-tissue-expression-data
Aug 31, 2026
mc5r
gap/no-fulltext-access
gap/unsourced
gap/needs-human-replication
gap/no-mechanism
gap/needs-gtex-query
gap/dose-response-unclear
Aug 31, 2026
ldlr
gap/needs-canonical-id
gap/needs-replication
gap/unsourced
gap/needs-human-replication
gap/no-mechanism
gap/no-fulltext-access
Aug 31, 2026
lgals3
gap/needs-canonical-id
gap/no-fulltext-access
gap/needs-replication
gap/needs-verification
gap/no-mechanism
gap/contradictory-evidence
gap/needs-human-replication
Aug 31, 2026
lh
gap/needs-human-replication
gap/needs-replication
gap/needs-canonical-id
Aug 31, 2026
lig1
gap/needs-canonical-id
gap/no-mechanism
gap/unsourced
gap/needs-human-replication
gap/needs-replication
Aug 31, 2026
lin28
gap/needs-replication
gap/unsourced
gap/no-mechanism
gap/needs-human-replication
gap/long-term-unknown
gap/needs-canonical-id
Aug 31, 2026
lipa
gap/dose-response-unclear
gap/needs-human-replication
gap/no-mechanism
gap/long-term-unknown
gap/needs-canonical-id
gap/unsourced
Aug 31, 2026
lox
gap/needs-human-replication
gap/long-term-unknown
gap/no-fulltext-access
gap/needs-replication
gap/no-mechanism
gap/dose-response-unclear
Aug 31, 2026
lpa
gap/needs-human-replication
gap/dose-response-unclear
gap/no-mechanism
gap/contradictory-evidence
gap/unsourced
Aug 31, 2026
jak2
gap/no-mechanism
gap/needs-human-replication
gap/needs-canonical-id
gap/dose-response-unclear
gap/no-fulltext-access
Aug 31, 2026
kit
gap/contradictory-evidence
gap/needs-replication
gap/no-mechanism
gap/needs-human-replication
stub
gap/needs-canonical-id
gap/no-fulltext-access
Aug 31, 2026
kitlg
gap/contradictory-evidence
gap/needs-replication
gap/needs-human-replication
gap/no-mechanism
gap/long-term-unknown
gap/needs-canonical-id
Aug 31, 2026
klf4
gap/needs-human-replication
gap/needs-replication
gap/unsourced
gap/contradictory-evidence
gap/no-mechanism
Aug 31, 2026
klotho
gap/needs-replication
gap/no-fulltext-access
gap/needs-human-replication
gap/no-mechanism
gap/contradictory-evidence
gap/dose-response-unclear
gap/no-opentargets-entry
stub
Aug 31, 2026
ku70-ku80
gap/unsourced
stub
gap/contradictory-evidence
gap/needs-human-replication
gap/no-fulltext-access
gap/no-mechanism
gap/needs-replication
Aug 31, 2026
lamp2
gap/needs-canonical-id
gap/unsourced
gap/needs-replication
gap/needs-human-replication
gap/no-mechanism
gap/long-term-unknown
Aug 31, 2026
lc3
gap/unsourced
gap/needs-human-replication
gap/needs-replication
gap/no-mechanism
Aug 31, 2026
insr
gap/needs-replication
gap/unsourced
gap/needs-canonical-id
gap/no-mechanism
gap/needs-human-replication
gap/contradictory-evidence
gap/long-term-unknown
Aug 31, 2026
insulin
gap/needs-replication
gap/unsourced
gap/needs-human-replication
gap/no-mechanism
gap/contradictory-evidence
gap/needs-canonical-id
gap/no-fulltext-access
Aug 31, 2026
irak4
gap/unsourced
gap/needs-human-replication
gap/needs-replication
gap/no-fulltext-access
gap/needs-gtex-lookup
Aug 31, 2026
irf3
gap/needs-canonical-id
gap/needs-human-replication
gap/long-term-unknown
gap/needs-mechanism-clarity
gap/needs-gtex-query
gap/needs-replication
Aug 31, 2026
irf7
gap/needs-replication
gap/no-mechanism
Aug 31, 2026
irf9
gap/no-mechanism
gap/needs-replication
gap/needs-human-replication
gap/needs-canonical-id
Aug 31, 2026
irs-1
gap/needs-canonical-id
gap/unsourced
gap/contradictory-evidence
gap/no-fulltext-access
gap/needs-replication
gap/needs-human-replication
gap/no-mechanism
Aug 31, 2026
irs2
gap/needs-canonical-id
gap/needs-human-replication
gap/no-fulltext-access
gap/no-mechanism
gap/needs-replication
Aug 31, 2026
jak1
gap/needs-human-replication
gap/long-term-unknown
gap/no-mechanism
gap/dose-response-unclear
gap/needs-canonical-id
gap/no-fulltext-access
Aug 31, 2026
il-11-receptor-alpha-1
gap/long-term-unknown
gap/needs-human-replication
gap/needs-gtex-aging-correlation
Aug 31, 2026
il-11
gap/contradictory-evidence
gap/needs-replication
gap/needs-human-replication
gap/long-term-unknown
gap/needs-gtex-aging-correlation
Aug 31, 2026
il-18
gap/needs-replication
gap/no-mechanism
gap/no-fulltext-access
Aug 31, 2026
il-1a
gap/needs-human-replication
gap/needs-replication
gap/contradictory-evidence
gap/needs-gtex-data
gap/needs-canonical-id
gap/no-fulltext-access
Aug 31, 2026
il-1b
gap/needs-replication
gap/needs-human-replication
gap/unsourced
gap/contradictory-evidence
gap/dose-response-unclear
gap/no-fulltext-access
Aug 31, 2026
il-1r1
gap/needs-replication
gap/needs-citation
gap/unsourced
Aug 31, 2026
il-1ra
gap/no-mechanism
gap/needs-replication
gap/not-queried
gap/needs-canonical-id
gap/unsourced
gap/no-fulltext-access
Aug 31, 2026
il-6
gap/needs-human-replication
gap/needs-gtex-aging-correlation
gap/no-mechanism
gap/contradictory-evidence
gap/dose-response-unclear
gap/needs-full-pdf-verification
Aug 31, 2026
inhba
gap/needs-human-replication
gap/needs-replication
gap/no-mechanism
gap/dose-response-unclear
gap/contradictory-evidence
gap/needs-tissue-expression-data
gap/no-fulltext-access
Aug 31, 2026
hsp70
gap/needs-canonical-id
gap/unsourced
gap/needs-human-replication
gap/no-fulltext-access
gap/needs-replication
gap/no-mechanism
gap/dose-response-unclear
gap/long-term-unknown
Aug 31, 2026
hsp90
stub
gap/needs-human-replication
gap/no-mechanism
gap/needs-citation
gap/long-term-unknown
gap/needs-replication
gap/no-fulltext-access
Aug 31, 2026
hyal2
gap/needs-human-replication
gap/contradictory-evidence
gap/needs-selective-inhibitor
gap/needs-tissue-expression-check
gap/needs-replication
Aug 31, 2026
ifnar1
gap/needs-replication
gap/unsourced
gap/needs-human-replication
Aug 31, 2026
ifnar2
gap/needs-replication
gap/no-mechanism
gap/needs-human-replication
gap/no-fulltext-access
gap/not-populated
Aug 31, 2026
igf-1
gap/needs-replication
gap/contradictory-evidence
gap/long-term-unknown
gap/needs-human-replication
gap/dose-response-unclear
gap/unsourced
gap/no-fulltext-access
Aug 31, 2026
igf1r
gap/needs-replication
gap/no-mechanism
gap/dose-response-unclear
gap/needs-human-replication
gap/contradictory-evidence
gap/no-fulltext-access
Aug 31, 2026
ikbke
gap/needs-human-replication
gap/needs-replication
gap/no-mechanism
gap/dose-response-unclear
gap/long-term-unknown
Aug 31, 2026
has2
gap/needs-canonical-id
gap/needs-verification
gap/contradictory-evidence
gap/needs-human-replication
gap/unsourced
gap/no-mechanism
gap/dose-response-unclear
gap/needs-replication
Aug 31, 2026
hdac
gap/needs-human-replication
gap/needs-replication
gap/needs-canonical-id
gap/contradictory-evidence
gap/no-mechanism
gap/long-term-unknown
Aug 31, 2026
hepcidin
gap/needs-canonical-id
gap/no-mechanism
gap/unsourced
gap/needs-replication
gap/long-term-unknown
gap/needs-human-replication
gap/no-fulltext-access
Aug 31, 2026
hgf
gap/needs-canonical-id
gap/needs-replication
gap/needs-human-replication
gap/no-fulltext-access
Aug 31, 2026
hmgb1
gap/needs-replication
gap/dose-response-unclear
Aug 31, 2026
hmgcr
gap/dose-response-unclear
gap/contradictory-evidence
gap/no-mechanism
gap/needs-human-replication
gap/long-term-unknown
Aug 31, 2026
hsc70
gap/unsourced
gap/needs-replication
gap/contradictory-evidence
gap/needs-human-replication
gap/dose-response-unclear
gap/no-mechanism
gap/needs-canonical-id
Aug 31, 2026
hsd11b1-hsd11b2
gap/needs-canonical-id
gap/needs-replication
gap/needs-human-replication
gap/unsourced
Aug 31, 2026
hsf1
gap/no-mechanism
gap/needs-human-replication
gap/needs-replication
gap/dose-response-unclear
gap/unsourced
gap/needs-canonical-id
gap/contradictory-evidence
gap/no-fulltext-access
Aug 31, 2026
gpr109a
gap/needs-human-replication
gap/needs-replication
gap/contradictory-evidence
gap/no-mechanism
gap/unsourced
Aug 31, 2026
gpr41
gap/needs-replication
gap/contradictory-evidence
gap/unsourced
gap/needs-human-replication
gap/no-mechanism
gap/no-fulltext-access
Aug 31, 2026
gpr43
gap/no-fulltext-access
gap/unsourced
gap/needs-human-replication
gap/needs-replication
gap/no-mechanism
gap/no-opentargets-entry
gap/long-term-unknown
gap/dose-response-unclear
Aug 31, 2026
grb2
gap/no-mechanism
gap/needs-human-replication
gap/dose-response-unclear
gap/needs-canonical-id
Aug 31, 2026
grk2
gap/needs-human-replication
gap/needs-replication
gap/no-mechanism
gap/needs-canonical-id
gap/dose-response-unclear
Aug 31, 2026
growth-hormone-receptor
gap/needs-citation
gap/needs-replication
gap/contradictory-evidence
gap/stub
gap/no-mechanism
gap/needs-human-replication
gap/not-queried
Aug 31, 2026
growth-hormone
gap/needs-replication
gap/needs-human-replication
gap/long-term-unknown
gap/dose-response-unclear
gap/no-mechanism
gap/unsourced
gap/needs-canonical-id
gap/no-fulltext-access
Aug 31, 2026
gsdmd
gap/no-mechanism
gap/needs-human-replication
gap/needs-replication
gap/long-term-unknown
gap/needs-canonical-id
gap/no-fulltext-access
Aug 31, 2026
gcn2
gap/no-mechanism
gap/contradictory-evidence
gap/needs-human-replication
gap/needs-replication
gap/unsourced
gap/long-term-unknown
gap/dose-response-unclear
gap/no-fulltext-access
Aug 31, 2026
gdf11
gap/contradictory-evidence
gap/needs-human-replication
gap/no-fulltext-access
gap/no-mechanism
gap/needs-replication
gap/no-opentargets-entry
Aug 31, 2026
gdf15
gap/needs-replication
gap/no-mechanism
gap/unsourced
gap/long-term-unknown
gap/needs-human-replication
gap/needs-canonical-id
gap/dose-response-unclear
gap/no-fulltext-access
Aug 31, 2026
ggcx
gap/needs-gtex-aging-correlation
gap/needs-human-replication
gap/no-fulltext-access
Aug 31, 2026
ghsr
gap/no-mechanism
gap/no-fulltext-access
gap/contradictory-evidence
gap/needs-human-replication
Aug 31, 2026
glo1
gap/dose-response-unclear
gap/needs-replication
gap/no-mechanism
gap/needs-human-replication
gap/long-term-unknown
gap/no-fulltext-access
Aug 31, 2026
glut4
gap/no-fulltext-access
gap/needs-replication
gap/needs-human-replication
gap/no-mechanism
gap/dose-response-unclear
gap/long-term-unknown
gap/contradictory-evidence
gap/unsourced
Aug 31, 2026
gp130
gap/needs-gtex-aging-correlation
Aug 31, 2026
gper
gap/contradictory-evidence
gap/unsourced
gap/needs-human-replication
gap/long-term-unknown
Aug 31, 2026
gpnmb
gap/needs-genage-check
gap/needs-human-replication
gap/no-aging-validated-probe
gap/needs-clinical-trials-recheck
gap/contradictory-evidence
gap/no-mechanism
gap/needs-gtex-age-stratified
Aug 31, 2026
foxo3
gap/needs-replication
gap/unsourced
gap/contradictory-evidence
gap/no-mechanism
gap/no-fulltext-access
gap/needs-human-replication
gap/dose-response-unclear
gap/long-term-unknown
Aug 31, 2026
foxo4
gap/needs-canonical-id
gap/unsourced
gap/needs-replication
gap/needs-human-replication
gap/long-term-unknown
gap/no-fulltext-access
Aug 31, 2026
fpr2
gap/needs-replication
gap/needs-human-replication
gap/needs-aging-trial
gap/contradictory-evidence
gap/needs-canonical-id
gap/no-fulltext-access
Aug 31, 2026
fsh
gap/dose-response-unclear
gap/needs-human-replication
gap/contradictory-evidence
gap/long-term-unknown
gap/needs-replication
gap/no-fulltext-access
Aug 31, 2026
fth1
gap/not-in-genage
gap/needs-human-replication
gap/no-fulltext-access
Aug 31, 2026
ftl1
gap/not-in-genage
gap/long-term-unknown
gap/dose-response-unclear
gap/no-mechanism
Aug 31, 2026
fundc1
gap/no-fulltext-access
gap/no-mechanism
gap/needs-replication
gap/needs-human-replication
gap/needs-canonical-id
gap/long-term-unknown
Aug 31, 2026
fut8
gap/needs-replication
gap/no-fulltext-access
Aug 31, 2026
fgf23
gap/needs-replication
gap/contradictory-evidence
gap/needs-trials-check
gap/needs-druggability-check
stub
gap/needs-gtex-extraction
gap/no-fulltext-access
Aug 31, 2026
fgfr1
gap/needs-human-replication
gap/needs-replication
gap/contradictory-evidence
gap/no-mechanism
gap/needs-tissue-expression-data
gap/long-term-unknown
gap/no-fulltext-access
Aug 31, 2026
fip200
gap/needs-canonical-id
gap/unsourced
gap/needs-replication
gap/needs-human-replication
gap/no-mechanism
Aug 31, 2026
fis1
gap/needs-replication
gap/unsourced
gap/needs-human-replication
gap/no-mechanism
gap/no-fulltext-access
Aug 31, 2026
fkbp12
gap/needs-replication
gap/no-mechanism
gap/contradictory-evidence
gap/long-term-unknown
gap/dose-response-unclear
gap/needs-human-replication
gap/no-fulltext-access
Aug 31, 2026
fn3k
gap/needs-replication
gap/needs-peer-review
gap/no-mechanism
Aug 31, 2026
foxo-transcription-factors
gap/unsourced
gap/needs-replication
gap/needs-canonical-id
gap/no-mechanism
gap/needs-human-replication
gap/dose-response-unclear
gap/no-fulltext-access
Aug 31, 2026
foxo1
gap/unsourced
gap/needs-replication
gap/needs-human-replication
gap/contradictory-evidence
gap/long-term-unknown
Aug 31, 2026
fancd2
gap/needs-canonical-id
gap/needs-verification
gap/needs-human-replication
gap/no-fulltext-access
gap/no-mechanism
gap/needs-replication
stub
gap/long-term-unknown
gap/needs-gtex-query
Aug 31, 2026
fanci
gap/no-fulltext-access
gap/needs-human-replication
gap/needs-replication
gap/unsourced
stub
Aug 31, 2026
fbn1
gap/needs-canonical-id
gap/no-fulltext-access
gap/no-mechanism
gap/unsourced
gap/needs-human-replication
gap/needs-replication
Aug 31, 2026
ferritin
gap/needs-human-replication
gap/dose-response-unclear
gap/contradictory-evidence
gap/unsourced
gap/needs-replication
gap/no-mechanism
gap/no-fulltext-access
Aug 31, 2026
ferroportin
gap/needs-canonical-id
gap/contradictory-evidence
gap/needs-replication
gap/needs-human-replication
gap/long-term-unknown
stub
gap/no-fulltext-access
Aug 31, 2026
fgf2
gap/needs-human-replication
gap/no-mechanism
gap/no-opentargets-entry
gap/needs-replication
gap/needs-tissue-expression-data
gap/contradictory-evidence
gap/no-fulltext-access
Aug 31, 2026
fgf21
gap/needs-canonical-id
gap/needs-replication
gap/needs-human-replication
gap/needs-mechanistic-detail
gap/no-human-aging-trial
gap/long-term-unknown
Aug 31, 2026
drp1
gap/no-fulltext-access
gap/contradictory-evidence
gap/needs-replication
gap/unsourced
gap/no-mechanism
gap/dose-response-unclear
Aug 31, 2026
eda2r
gap/no-fulltext-access
gap/no-aging-probe
gap/no-mechanism
gap/needs-population-evidence
gap/needs-gtex-quantification
gap/unsourced
gap/needs-replication
Aug 31, 2026
eif2alpha
gap/needs-human-replication
gap/contradictory-evidence
Aug 31, 2026
eln
gap/needs-replication
gap/no-mechanism
gap/unsourced
gap/needs-canonical-id
gap/no-fulltext-access
Aug 31, 2026
enos
gap/no-fulltext-access
gap/no-mechanism
gap/needs-replication
gap/needs-human-replication
Aug 31, 2026
ep300
gap/unsourced
gap/needs-replication
gap/needs-human-replication
gap/long-term-unknown
gap/contradictory-evidence
gap/no-mechanism
Aug 31, 2026
ercc1
gap/needs-replication
gap/needs-human-replication
gap/unsourced
gap/no-mechanism
gap/needs-canonical-id
Aug 31, 2026
esr1
gap/contradictory-evidence
gap/needs-human-replication
Aug 31, 2026
esr2
gap/needs-canonical-id
gap/needs-replication
gap/contradictory-evidence
gap/needs-human-replication
gap/no-fulltext-access
Aug 31, 2026
cyp19a1
gap/needs-canonical-id
gap/needs-human-replication
gap/needs-replication
gap/dose-response-unclear
Aug 31, 2026
cytochrome-c
gap/unsourced
gap/needs-replication
gap/needs-human-replication
gap/no-mechanism
gap/needs-canonical-id
gap/no-fulltext-access
Aug 31, 2026
daf-16
gap/needs-canonical-id
gap/needs-replication
gap/needs-human-replication
gap/no-fulltext-access
gap/no-mechanism
Aug 31, 2026
daf-2
gap/needs-canonical-id
gap/needs-replication
gap/no-fulltext-access
gap/needs-human-replication
gap/no-mechanism
gap/long-term-unknown
Aug 31, 2026
deptor
gap/needs-replication
gap/contradictory-evidence
gap/unsourced
gap/needs-human-replication
Aug 31, 2026
dkc1
gap/no-fulltext-access
gap/needs-replication
gap/stub
gap/long-term-unknown
Aug 31, 2026
dkk1
gap/needs-human-replication
gap/needs-current-trial-status
gap/dose-response-unclear
gap/no-fulltext-access
Aug 31, 2026
dna-pkcs
gap/no-genage-entry
gap/needs-replication
gap/needs-human-replication
gap/no-mechanism
gap/long-term-unknown
gap/dose-response-unclear
Aug 31, 2026
dnmt1
gap/no-mechanism
gap/needs-replication
gap/no-fulltext-access
Aug 31, 2026
dnmt3a
gap/needs-replication
gap/needs-human-replication
gap/no-mechanism
Aug 31, 2026
chrna7
gap/needs-human-replication
gap/unsourced
gap/contradictory-evidence
gap/long-term-unknown
gap/needs-stub
gap/no-mechanism
gap/not-queried
Aug 31, 2026
col1a1
gap/needs-replication
gap/unsourced
gap/no-fulltext-access
gap/dose-response-unclear
gap/needs-human-replication
gap/contradictory-evidence
Aug 31, 2026
col3a1
gap/needs-replication
gap/unsourced
gap/dose-response-unclear
gap/needs-human-replication
gap/no-mechanism
Aug 31, 2026
comt
gap/contradictory-evidence
gap/needs-replication
gap/needs-human-replication
gap/needs-canonical-id
Aug 31, 2026
crh
gap/needs-canonical-id
gap/contradictory-evidence
gap/no-mechanism
gap/needs-human-replication
gap/needs-tissue-expression-data
gap/no-fulltext-access
Aug 31, 2026
cst7
gap/needs-verification
gap/needs-human-replication
gap/no-mechanism
gap/dose-response-unclear
Aug 31, 2026
cxcl12
gap/needs-replication
gap/needs-human-replication
gap/no-mechanism
gap/long-term-unknown
gap/no-fulltext-access
Aug 31, 2026
cxcr4
gap/not-populated
gap/needs-replication
gap/no-mechanism
Aug 31, 2026
caspase-3
gap/unsourced
gap/needs-replication
gap/no-mechanism
gap/needs-human-replication
gap/no-fulltext-access
Aug 31, 2026
caspase-7
gap/unsourced
gap/needs-human-replication
gap/needs-replication
gap/no-mechanism
Aug 31, 2026
caspase-8
gap/unsourced
gap/needs-human-replication
gap/no-mechanism
gap/needs-replication
Aug 31, 2026
caspase-9
gap/needs-replication
gap/needs-human-replication
gap/unsourced
gap/no-mechanism
Aug 31, 2026
cbp-p300
gap/needs-replication
gap/needs-human-replication
gap/no-mechanism
gap/long-term-unknown
gap/contradictory-evidence
gap/no-fulltext-access
Aug 31, 2026
ccl11
gap/unsourced
gap/needs-replication
gap/needs-human-replication
gap/no-mechanism
gap/no-fulltext-access
gap/long-term-unknown
Aug 31, 2026
cd44
gap/needs-isoform-resolution
gap/no-mechanism
gap/contradictory-evidence
gap/needs-human-replication
gap/needs-replication
Aug 31, 2026
cgas
gap/needs-replication
gap/no-fulltext-access
gap/needs-human-replication
gap/needs-canonical-id
gap/unsourced
Aug 31, 2026
bim
gap/needs-canonical-id
gap/no-fulltext-access
gap/needs-replication
gap/contradictory-evidence
gap/needs-human-replication
gap/unsourced
gap/no-mechanism
Aug 31, 2026
bmp-2
gap/needs-canonical-id
gap/unsourced
gap/no-mechanism
gap/needs-replication
gap/no-fulltext-access
gap/needs-human-replication
gap/dose-response-unclear
Aug 31, 2026
bnip3
gap/needs-human-replication
gap/needs-replication
gap/no-mechanism
gap/contradictory-evidence
gap/needs-canonical-id
gap/unsourced
gap/no-fulltext-access
Aug 31, 2026
brca1
gap/no-fulltext-access
gap/needs-replication
gap/unsourced
gap/needs-canonical-id
gap/needs-human-replication
gap/contradictory-evidence
gap/dose-response-unclear
Aug 31, 2026
brca2
gap/needs-replication
gap/needs-human-replication
gap/unsourced
gap/no-fulltext-access
gap
gap/needs-gtex-data
Aug 31, 2026
c-met
gap/needs-replication
gap/needs-human-replication
gap/no-mechanism
gap/long-term-unknown
Aug 31, 2026
c-myc
gap/unsourced
gap/needs-replication
gap/needs-human-replication
gap/dose-response-unclear
gap/no-mechanism
gap/no-fulltext-access
Aug 31, 2026
camp
gap/needs-canonical-id
gap/needs-gtex-aging-data
gap/needs-human-replication
gap/contradictory-evidence
gap/needs-replication
gap/no-mechanism
Aug 31, 2026
caspase-1
gap/needs-human-replication
gap/needs-replication
gap/no-mechanism
gap/long-term-unknown
gap/needs-stub
gap/no-fulltext-access
Aug 31, 2026
bcl-2
gap/dose-response-unclear
gap/long-term-unknown
gap/needs-human-replication
gap/needs-replication
gap/no-mechanism
gap/contradictory-evidence
gap/unsourced
gap/no-fulltext-access
Aug 31, 2026
bcl-w
gap/needs-canonical-id
gap/needs-replication
gap/needs-human-replication
gap/unsourced
gap/contradictory-evidence
gap/long-term-unknown
gap/no-fulltext-access
Aug 31, 2026
bcl-xl
gap/needs-canonical-id
gap/needs-replication
gap/no-fulltext-access
gap/long-term-unknown
gap/no-mechanism
gap/needs-human-replication
gap/unsourced
Aug 31, 2026
bcl2l13
gap/no-mechanism
gap/needs-replication
gap/needs-human-replication
gap/no-fulltext-access
gap/needs-canonical-id
Aug 31, 2026
bdnf
gap/needs-replication
gap/needs-human-replication
gap/no-mechanism
gap/needs-gtex-aging-correlation
gap/dose-response-unclear
gap/no-fulltext-access
Aug 31, 2026
beclin-1
gap/needs-human-replication
gap/no-fulltext-access
gap/unsourced
gap/needs-canonical-id
gap/no-mechanism
Aug 31, 2026
beta-arrestin2
gap/not-populated
gap/needs-replication
gap/needs-human-replication
gap/no-mechanism
gap/contradictory-evidence
Aug 31, 2026
bid
gap/needs-replication
gap/unsourced
gap/needs-human-replication
gap/no-mechanism
gap/no-fulltext-access
Aug 31, 2026
atg5
gap/no-fulltext-access
gap/unsourced
gap/needs-human-replication
gap/needs-replication
Aug 31, 2026
atg7
gap/needs-human-replication
gap/needs-replication
gap/no-fulltext-access
Aug 31, 2026
atm
gap/no-fulltext-access
gap/needs-replication
gap/no-mechanism
gap/needs-human-replication
gap/unsourced
Aug 31, 2026
atp6v1b2
stub
gap/needs-canonical-id
gap/no-mechanism
gap/preprint-not-peer-reviewed
gap/needs-replication
Aug 31, 2026
atr
gap/needs-canonical-id
gap/needs-primary-source
gap/needs-human-replication
gap/no-mechanism
gap/unsourced
gap/needs-replication
gap/no-fulltext-access
Aug 31, 2026
b2m
gap/needs-human-replication
gap/dose-response-unclear
gap/needs-replication
gap/no-mechanism
gap/contradictory-evidence
Aug 31, 2026
b4galt1
gap/no-mechanism
gap/needs-replication
gap/needs-human-replication
gap/no-fulltext-access
Aug 31, 2026
bad
gap/needs-canonical-id
gap/needs-primary-source
gap/needs-replication
gap/contradictory-evidence
gap/unsourced
gap/needs-human-replication
gap/no-fulltext-access
gap/long-term-unknown
Aug 31, 2026
bak
gap/unsourced
gap/needs-replication
gap/needs-human-replication
gap/dose-response-unclear
gap/no-mechanism
Aug 31, 2026
bax
gap/needs-human-replication
gap/no-mechanism
gap/dose-response-unclear
gap/needs-replication
Aug 31, 2026
asc
gap/needs-human-replication
gap/needs-replication
gap/needs-canonical-id
gap/unsourced
gap/no-mechanism
gap/dose-response-unclear
gap/no-fulltext-access
Aug 31, 2026
asm
gap/unsourced
Aug 31, 2026
asxl1
gap/no-mechanism
gap/needs-replication
gap/needs-canonical-id
gap/unsourced
gap/no-fulltext-access
Aug 31, 2026
atf4
gap/needs-replication
gap/unsourced
gap/needs-human-replication
gap/dose-response-unclear
Aug 31, 2026
atg10
gap/needs-replication
gap/needs-human-replication
gap/unsourced
Aug 31, 2026
atg101
gap/needs-human-replication
gap/no-mechanism
gap/no-fulltext-access
gap/needs-replication
gap/unsourced
gap/needs-canonical-id
Aug 31, 2026
atg12
gap/needs-replication
gap/no-mechanism
gap/unsourced
gap/no-fulltext-access
Aug 31, 2026
atg13
gap/needs-canonical-id
gap/needs-replication
gap/unsourced
gap/no-mechanism
gap/needs-human-replication
gap/no-fulltext-access
Aug 31, 2026
atg16l1
gap/unsourced
gap/needs-replication
gap/needs-human-replication
gap/no-mechanism
gap/no-fulltext-access
Aug 31, 2026
atg3
gap/needs-human-replication
gap/needs-replication
gap/no-mechanism
gap/no-fulltext-access
Aug 31, 2026
alpha-msh
gap/needs-human-replication
gap/needs-canonical-id
gap/needs-tissue-expression-data
gap/long-term-unknown
gap/no-fulltext-access
Aug 31, 2026
alpha-synuclein
gap/needs-replication
gap/unsourced
gap/contradictory-evidence
gap/needs-human-replication
gap/long-term-unknown
gap/dose-response-unclear
gap/no-mechanism
gap/no-fulltext-access
Aug 31, 2026
amh
gap/needs-human-replication
gap/needs-replication
gap/no-mechanism
gap/needs-canonical-id
Aug 31, 2026
apaf-1
gap/needs-replication
gap/unsourced
gap/no-mechanism
gap/needs-canonical-id
Aug 31, 2026
ape1
gap/unsourced
gap/no-fulltext-access
gap/needs-replication
gap/no-mechanism
gap/needs-human-replication
gap/dose-response-unclear
Aug 31, 2026
apob
gap/needs-human-replication
gap/unsourced
gap/no-fulltext-access
gap/needs-replication
Aug 31, 2026
apoe
gap/needs-replication
gap/contradictory-evidence
gap/no-mechanism
gap/long-term-unknown
gap/needs-human-replication
gap/unsourced
gap/needs-canonical-id
Aug 31, 2026
14-3-3
gap/needs-replication
gap/needs-primary-source
gap/unsourced
gap/long-term-unknown
gap/needs-canonical-id
gap/needs-human-replication
gap/dose-response-unclear
gap/no-fulltext-access
Aug 31, 2026
15-pgdh
gap/no-mechanism
gap/needs-human-replication
gap/needs-pk-data
gap/proprietary-chemistry
gap/long-term-unknown
gap/contradictory-evidence
gap/dose-response-unclear
gap/needs-canonical-id
Aug 31, 2026
4ebp1
gap/needs-canonical-id
gap/unsourced
gap/no-mechanism
gap/needs-human-replication
gap/needs-replication
gap/dose-response-unclear
gap/no-fulltext-access
Aug 31, 2026
ackr3
gap/needs-replication
gap/long-term-unknown
gap/no-mechanism
gap/contradictory-evidence
gap/needs-human-replication
Aug 31, 2026
age-1
gap/needs-replication
gap/needs-human-replication
gap/dose-response-unclear
gap/no-mechanism
gap/no-fulltext-access
Aug 31, 2026
akt
gap/needs-human-replication
gap/needs-replication
gap/contradictory-evidence
gap/long-term-unknown
Aug 31, 2026
aldh1a1
gap/needs-canonical-id
gap/needs-human-replication
gap/contradictory-evidence
gap/no-mechanism
gap/unsourced
gap/no-opentargets-entry
stub
Aug 31, 2026
aldh1a2
gap/no-fulltext-access
gap/needs-epigenetic-aging-citation
gap/no-opentargets-entry
gap/needs-human-replication
gap/needs-aging-expression-data
gap/needs-mouse-aging-expression
gap/dose-response-unclear
Aug 31, 2026
aldh1a3
gap/needs-replication
gap/needs-human-replication
gap/no-mechanism
gap/stub
Aug 31, 2026
vitamin-d
gap/needs-human-replication
gap/contradictory-evidence
gap/no-mechanism
gap/needs-replication
gap/dose-response-unclear
stub
Aug 31, 2026
vitamin-k
gap/contradictory-evidence
gap/needs-human-replication
gap/dose-response-unclear
gap/no-fulltext-access
Aug 31, 2026
vitamin-k2
gap/needs-canonical-id
gap/needs-replication
gap/long-term-unknown
gap/dose-response-unclear
gap/no-mechanism
Aug 31, 2026
zoc2017217
gap/needs-canonical-id
gap/no-mechanism
gap/needs-human-replication
gap/long-term-unknown
gap/dose-response-unclear
Aug 31, 2026
acetylcholine
gap/contradictory-evidence
gap/needs-replication
gap/no-mechanism
gap/long-term-unknown
gap/needs-human-replication
gap/dose-response-unclear
gap/stub
Aug 31, 2026
catecholamines
gap/needs-replication
gap/needs-human-replication
gap/no-mechanism
gap/contradictory-evidence
gap/stub
gap/dose-response-unclear
Aug 31, 2026
iron
gap/needs-replication
gap/unsourced
gap/needs-human-replication
gap/no-mechanism
gap/long-term-unknown
gap/contradictory-evidence
gap/stub
gap/dose-response-unclear
gap/no-fulltext-access
Aug 31, 2026
testosterone
gap/no-mechanism
gap/contradictory-evidence
gap/long-term-unknown
gap/needs-replication
gap/dose-response-unclear
gap/needs-full-text
Aug 31, 2026
tinosorb-a2b
gap/needs-sccs-opinion-reference-confirmed
gap/no-human-rct
gap/no-independent-replication
gap/no-biopsy-endpoint
gap/long-term-unknown
gap/no-fulltext-access
gap/no-mechanism
Aug 31, 2026
tirzepatide
gap/needs-canonical-id
gap/no-mechanism
gap/needs-human-replication
gap/needs-replication
gap/dose-response-unclear
gap/unsourced
Aug 31, 2026
tocilizumab
gap/needs-canonical-id
gap/no-fulltext-access
gap/needs-replication
gap/unsourced
gap/needs-human-replication
gap/long-term-unknown
gap/dose-response-unclear
Aug 31, 2026
tretinoin
gap/needs-replication
gap/no-fulltext-access
gap/long-term-unknown
gap/contradictory-evidence
gap/needs-human-replication
gap/dose-response-unclear
gap/needs-canonical-id
Aug 31, 2026
triasorb
gap/no-independent-replication
gap/no-direct-comparator-rct
gap/long-term-unknown
Aug 31, 2026
urolithin-a
gap/no-fulltext-access
gap/dose-response-unclear
gap/no-mechanism
gap/needs-replication
gap/long-term-unknown
gap/unsourced
Aug 31, 2026
spermidine
gap/needs-replication
gap/no-mechanism
gap/dose-response-unclear
gap/long-term-unknown
gap/needs-human-replication
gap/contradictory-evidence
gap/no-fulltext-access
Aug 31, 2026
sw033291
gap/needs-canonical-id
gap/needs-pdf-verification
gap/needs-replication
gap/contradictory-evidence
gap/needs-human-replication
gap/dose-response-unclear
gap/long-term-unknown
gap/unsourced
Aug 31, 2026
tafamidis
gap/needs-canonical-id
gap/contradictory-evidence
gap/needs-replication
gap/needs-human-replication
Aug 31, 2026
taurine
gap/contradictory-evidence
gap/needs-human-replication
gap/no-fulltext-access
gap/long-term-unknown
gap/needs-replication
theory/unsubstantiated
gap/dose-response-unclear
Aug 31, 2026
tazarotene
gap/needs-replication
gap/long-term-unknown
gap/no-fulltext-access
Aug 31, 2026
tb-500
gap/no-fulltext-access
gap/needs-canonical-id
gap/no-mechanism
gap/dose-response-unclear
gap/needs-replication
gap/needs-human-replication
gap/long-term-unknown
Aug 31, 2026
resveratrol
gap/dose-response-unclear
gap/contradictory-evidence
gap/no-mechanism
gap/needs-replication
gap/long-term-unknown
gap/needs-human-replication
Aug 31, 2026
retinaldehyde
gap/contradictory-evidence
gap/needs-replication
gap/needs-human-replication
gap/no-mechanism
gap/long-term-unknown
stub
Aug 31, 2026
retinol
gap/dose-response-unclear
gap/needs-replication
gap/needs-human-replication
gap/long-term-unknown
Aug 31, 2026
romosozumab
gap/needs-canonical-id
gap/contradictory-evidence
gap/needs-replication
gap/no-mechanism
gap/long-term-unknown
gap/no-fulltext-access
gap/needs-fulltext-verification
Aug 31, 2026
salicylic-acid
gap/needs-replication
gap/contradictory-evidence
gap/long-term-unknown
gap/stub
gap/no-mechanism
Aug 31, 2026
semaglutide
gap/needs-human-replication
gap/unsourced
gap/needs-healthy-population-replication
gap/no-mechanism
gap/needs-pdf-verification
gap/long-term-unknown
gap/dose-response-unclear
Aug 31, 2026
semax
gap/needs-canonical-id
gap/no-fulltext-access
gap/no-mechanism
gap/needs-replication
gap/unsourced
gap/needs-human-replication
gap/dose-response-unclear
Aug 31, 2026
setmelanotide
gap/needs-human-replication
gap/long-term-unknown
gap/needs-canonical-id
Aug 31, 2026
pdrn
gap/needs-human-replication
gap/needs-canonical-id
gap/needs-replication
gap/verify-outcomes
gap/contradictory-evidence
gap/long-term-unknown
gap/stub
gap/dose-response-unclear
Aug 31, 2026
piperlongumine
gap/needs-replication
gap/needs-human-replication
gap/dose-response-unclear
gap/needs-canonical-id
Aug 31, 2026
procyanidin-c1
gap/no-mechanism
gap/needs-replication
gap/needs-human-replication
gap/dose-response-unclear
gap/long-term-unknown
Aug 31, 2026
progesterone
gap/no-mechanism
gap/needs-replication
gap/needs-human-replication
gap/contradictory-evidence
gap/unsourced
gap/dose-response-unclear
Aug 31, 2026
quercetin
gap/needs-replication
gap/unsourced
gap/contradictory-evidence
gap/dose-response-unclear
gap/needs-human-replication
gap/long-term-unknown
gap/no-mechanism
Aug 31, 2026
rapamycin
gap/needs-replication
gap/needs-human-replication
gap/contradictory-evidence
gap/long-term-unknown
gap/dose-response-unclear
gap/no-mechanism
gap/no-fulltext-access
Aug 31, 2026
nmn
gap/needs-replication
gap/contradictory-evidence
gap/needs-human-replication
gap/long-term-unknown
gap/dose-response-unclear
Aug 31, 2026
nr
gap/unsourced
gap/no-mechanism
gap/contradictory-evidence
gap/dose-response-unclear
gap/needs-replication
gap/no-fulltext-access
gap/needs-human-replication
gap/long-term-unknown
gap/needs-canonical-id
stub
Aug 31, 2026
omega-3-fatty-acids
gap/contradictory-evidence
gap/needs-replication
gap/no-mechanism
gap/dose-response-unclear
gap/long-term-unknown
Aug 31, 2026
oxymetazoline
gap/needs-replication
gap/unsourced
gap/no-mechanism
gap/long-term-unknown
gap/stub
Aug 31, 2026
palmitic-acid
gap/needs-canonical-id
gap/needs-replication
gap/needs-human-replication
gap/dose-response-unclear
gap/no-mechanism
Aug 31, 2026
paroxetine
gap/needs-replication
Aug 31, 2026
patisiran
gap/needs-canonical-id
gap/contradictory-evidence
gap/long-term-unknown
Aug 31, 2026
melanotan-ii
gap/no-mechanism
gap/dose-response-unclear
gap/long-term-unknown
gap/needs-replication
gap/unsourced
gap/needs-human-replication
Aug 31, 2026
metformin
gap/no-mechanism
gap/needs-replication
gap/needs-human-replication
gap/contradictory-evidence
gap/long-term-unknown
gap/dose-response-unclear
Aug 31, 2026
methylglyoxal
gap/needs-human-replication
gap/contradictory-evidence
gap/no-mechanism
gap/no-fulltext-access
Aug 31, 2026
mexoryl-400
gap/no-independent-replication
gap/no-biopsy-endpoint
gap/needs-head-to-head-top-stack
gap/no-fulltext-access
Aug 31, 2026
mk-677
gap/dose-response-unclear
gap/needs-replication
gap/contradictory-evidence
gap/long-term-unknown
gap/unsourced
gap/needs-canonical-id
Aug 31, 2026
mots-c
gap/no-mechanism
gap/needs-replication
gap/contradictory-evidence
gap/needs-human-replication
gap/long-term-unknown
gap/dose-response-unclear
Aug 31, 2026
navitoclax
gap/needs-canonical-id
gap/needs-human-replication
gap/unsourced
gap/no-fulltext-access
gap/needs-citation
gap/needs-replication
gap/long-term-unknown
gap/no-mechanism
gap/dose-response-unclear
Aug 31, 2026
niacinamide
gap/needs-replication
gap/contradictory-evidence
gap/long-term-unknown
gap/unsourced
Aug 31, 2026
iscotrizinol
gap/needs-sccs-opinion-ref
gap/needs-human-replication
gap/no-isolated-compound-rct
gap/long-term-unknown
gap/no-fulltext-access
Aug 31, 2026
kpv
gap/needs-canonical-id
gap/no-mechanism
gap/needs-replication
gap/needs-human-replication
gap/unsourced
gap/dose-response-unclear
gap/long-term-unknown
gap/no-fulltext-access
Aug 31, 2026
l-theanine
gap/no-fulltext-access
gap/long-term-unknown
gap/dose-response-unclear
Aug 31, 2026
lactic-acid
gap/needs-replication
gap/dose-response-unclear
gap/needs-canonical-id
gap/long-term-unknown
gap/no-mechanism
gap/no-fulltext-access
Aug 31, 2026
lanosterol
gap/contradictory-evidence
gap/dose-response-unclear
gap/long-term-unknown
gap/needs-human-replication
Aug 31, 2026
lecanemab
gap/no-mechanism
gap/unsourced
gap/needs-replication
gap/long-term-unknown
gap/contradictory-evidence
gap/dose-response-unclear
Aug 31, 2026
ll-37
gap/needs-canonical-id
gap/contradictory-evidence
gap/needs-replication
gap/needs-human-replication
gap/no-fulltext-access
gap/long-term-unknown
gap/dose-response-unclear
Aug 31, 2026
lonafarnib
gap/needs-canonical-id
gap/dose-response-unclear
gap/no-fulltext-access
gap/needs-human-replication
gap/needs-replication
gap/long-term-unknown
gap/no-mechanism
Aug 31, 2026
meclizine
gap/long-term-unknown
gap/contradictory-evidence
gap/needs-replication
gap/no-mechanism
gap/dose-response-unclear
gap/no-fulltext-access
Aug 31, 2026
estradiol
gap/needs-human-replication
gap/contradictory-evidence
Aug 31, 2026
ezetimibe
gap/needs-replication
gap/contradictory-evidence
gap/long-term-unknown
gap/needs-human-replication
Aug 31, 2026
ferulic-acid
gap/no-mechanism
gap/dose-response-unclear
gap/needs-replication
stub
gap/needs-human-replication
Aug 31, 2026
fisetin
gap/no-mechanism
gap/needs-replication
gap/dose-response-unclear
gap/contradictory-evidence
gap/needs-human-replication
gap/long-term-unknown
gap/needs-full-paper-publication
Aug 31, 2026
flavan-3-ols
gap/dose-response-unclear
gap/no-mechanism
gap/contradictory-evidence
gap/needs-replication
gap/long-term-unknown
Aug 31, 2026
ghk-cu
gap/needs-canonical-id
gap/unsourced
gap/needs-replication
gap/contradictory-evidence
gap/needs-human-replication
gap/needs-canonical-hallmark-assignment
gap/dose-response-unclear
gap/long-term-unknown
Aug 31, 2026
glycolic-acid
gap/dose-response-unclear
gap/unsourced
gap/no-mechanism
gap/contradictory-evidence
gap/needs-replication
gap/long-term-unknown
gap/needs-human-replication
Aug 31, 2026
hyaluronic-acid
gap/unsourced
gap/needs-canonical-id
gap/contradictory-evidence
gap/no-mechanism
gap/needs-replication
gap/needs-human-replication
gap/dose-response-unclear
gap/long-term-unknown
Aug 31, 2026
dsip
gap/needs-canonical-id
gap/no-mechanism
gap/needs-human-replication
Aug 31, 2026
ecamsule
gap/no-independent-replication
gap/no-biopsy-endpoint
gap/long-term-unknown
gap/regulatory-gap
gap/no-fulltext-access
Aug 31, 2026
egcg
gap/needs-canonical-id
gap/needs-human-replication
gap/no-mechanism
gap/unsourced
gap/dose-response-unclear
gap/needs-replication
gap/contradictory-evidence
gap/long-term-unknown
Aug 31, 2026
elamipretide
gap/unsourced
gap/needs-replication
gap/needs-human-replication
gap/unverified-archive-failure
gap/dose-response-unclear
gap/no-mechanism
gap/doi-unconfirmed
gap/long-term-unknown
stub
gap/no-fulltext-access
Aug 31, 2026
empagliflozin
gap/unsourced
gap/needs-replication
gap/no-mechanism
gap/needs-human-replication
gap/long-term-unknown
stub
Aug 31, 2026
epitalon
gap/needs-canonical-id
gap/needs-replication
gap/no-mechanism
gap/needs-human-replication
gap/long-term-unknown
gap/unsourced
gap/no-fulltext-access
Aug 31, 2026
escin
gap/long-term-unknown
gap/no-mechanism
gap/needs-human-replication
gap/dose-response-unclear
gap/needs-replication
Aug 31, 2026
coq10
gap/needs-human-replication
gap/contradictory-evidence
gap/no-mechanism
gap/dose-response-unclear
gap/needs-replication
Aug 31, 2026
creatine
gap/no-mechanism
gap/needs-human-replication
gap/no-fulltext-access
gap/dose-response-unclear
gap/long-term-unknown
gap/contradictory-evidence
gap/needs-replication
Aug 31, 2026
dasatinib
gap/needs-replication
gap/dose-response-unclear
gap/needs-human-replication
gap/long-term-unknown
gap/no-mechanism
gap/unsourced
Aug 31, 2026
dihexa
gap/needs-canonical-id
gap/needs-replication
gap/unsourced
gap/no-mechanism
gap/dose-response-unclear
gap/long-term-unknown
gap/needs-human-replication
gap/no-fulltext-access
Aug 31, 2026
dihydromyricetin
gap/no-mechanism
gap/dose-response-unclear
gap/needs-replication
gap/needs-human-replication
gap/long-term-unknown
Aug 31, 2026
donanemab
gap/needs-canonical-id
gap/no-mechanism
gap/unsourced
gap/contradictory-evidence
gap/needs-replication
gap/long-term-unknown
gap/needs-human-replication
Aug 31, 2026
doxycycline
gap/needs-human-replication
gap/no-mechanism
gap/contradictory-evidence
gap/long-term-unknown
Aug 31, 2026
drometrizole-trisiloxane
gap/no-chembl-id
gap/comparative-spectral-data-needed
gap/no-independent-replication
gap/no-drt-isolated-efficacy-data
gap/no-biopsy-endpoint
gap/no-fda-pk-study
gap/long-term-unknown
gap/no-fulltext-access
gap/unverifiable-doi
Aug 31, 2026
berberine
gap/needs-ct-gov-count-refresh
gap/no-mechanism
gap/needs-replication
gap/contradictory-evidence
gap/needs-verification
gap/long-term-unknown
gap/no-fulltext-access
Aug 31, 2026
bisoctrizole
gap/no-direct-comparator-rct
gap/no-biopsy-endpoint
gap/long-term-unknown
gap/needs-canonical-id
gap/no-fulltext-access
Aug 31, 2026
bpc-157
gap/needs-canonical-id
gap/dose-response-unclear
gap/no-mechanism
gap/needs-human-replication
gap/no-fulltext-access
gap/needs-replication
gap/needs-regulatory-update
gap/long-term-unknown
Aug 31, 2026
brimonidine
gap/contradictory-evidence
gap/needs-replication
gap/long-term-unknown
gap/stub
Aug 31, 2026
canakinumab
gap/needs-canonical-id
gap/needs-replication
gap/long-term-unknown
gap/needs-human-replication
gap/dose-response-unclear
gap/contradictory-evidence
gap/unsourced
gap/no-fulltext-access
Aug 31, 2026
cmlase
gap/needs-human-replication
gap/needs-replication
gap/dose-response-unclear
gap/long-term-unknown
Aug 31, 2026
colchicine
gap/needs-canonical-id
gap/needs-human-replication
gap/needs-replication
gap/dose-response-unclear
Aug 31, 2026
amlexanox
gap/unsourced
gap/dose-response-unclear
gap/needs-human-replication
gap/needs-replication
gap/contradictory-evidence
gap/no-mechanism
Aug 31, 2026
anakinra
gap/needs-canonical-id
gap/needs-replication
gap/long-term-unknown
gap/needs-human-replication
gap/contradictory-evidence
gap/needs-verification
gap/unsourced
Aug 31, 2026
ascorbic-acid
gap/needs-replication
gap/dose-response-unclear
gap/needs-human-replication
gap/no-fulltext-access
Aug 31, 2026
astaxanthin
gap/no-mechanism
gap/no-fulltext-access
gap/contradictory-evidence
gap/needs-human-replication
gap/dose-response-unclear
gap/long-term-unknown
gap/unsourced
Aug 31, 2026
azelaic-acid
gap/stub
gap/no-mechanism
gap/needs-replication
gap/dose-response-unclear
gap/long-term-unknown
gap/contradictory-evidence
gap/no-fulltext-access
Aug 31, 2026
bakuchiol
gap/no-mechanism
gap/dose-response-unclear
gap/needs-replication
Aug 31, 2026
bemotrizinol
gap/needs-replication
gap/needs-head-to-head-us-vs-eu-stack
gap/no-biopsy-endpoint
gap/needs-canonical-id
gap/long-term-unknown
gap/no-fulltext-access
Aug 31, 2026
bempedoic-acid
gap/needs-replication
gap/dose-response-unclear
gap/no-mechanism
gap/needs-human-replication
gap/long-term-unknown
Aug 31, 2026
a1331852
gap/needs-replication
gap/no-fulltext-access
gap/long-term-unknown
gap/needs-human-replication
gap/unsourced
Aug 31, 2026
acoramidis
gap/needs-canonical-id
gap/needs-replication
gap/unsourced
gap/long-term-unknown
gap/contradictory-evidence
Aug 31, 2026
adapalene
gap/needs-replication
gap/long-term-unknown
gap/no-mechanism
Aug 31, 2026
akkermansia-supplementation
gap/needs-canonical-id
gap/needs-human-replication
gap/no-mechanism
gap/needs-replication
gap/long-term-unknown
gap/unsourced
gap/dose-response-unclear
gap/no-fulltext-access
Aug 31, 2026
alpha-tocopherol
gap/needs-replication
gap/needs-separate-page
gap/dose-response-unclear
gap/no-mechanism
gap/needs-human-replication
gap/contradictory-evidence
stub
gap/no-fulltext-access
Aug 31, 2026
nothobranchius-furzeri
gap/no-fulltext-access
gap/no-mechanism
gap/unsourced
gap/needs-human-replication
gap/needs-replication
Aug 31, 2026
rattus-norvegicus
gap/no-fulltext-access
gap/needs-replication
gap/unsourced
gap/needs-human-replication
Aug 31, 2026
saccharomyces-cerevisiae
gap/no-fulltext-access
gap/contradictory-evidence
gap/needs-human-replication
gap/no-mechanism
gap/unsourced
Aug 31, 2026
canis-lupus-familiaris
gap/needs-replication
gap/needs-citation-verification
gap/no-disclosure
gap/contradictory-evidence
gap/no-fulltext-access
Aug 31, 2026
drosophila-melanogaster
gap/needs-replication
gap/no-fulltext-access
gap/needs-human-replication
gap/unsourced
gap/contradictory-evidence
gap/no-mechanism
Aug 31, 2026
heterocephalus-glaber
gap/needs-replication
gap/contradictory-evidence
gap/needs-human-replication
gap/no-fulltext-access
gap/no-mechanism
gap/unsourced
Aug 31, 2026
homo-sapiens
gap/unsourced
gap/no-fulltext-access
gap/contradictory-evidence
gap/needs-replication
gap/long-term-unknown
gap/no-mechanism
Aug 31, 2026
loxodonta-africana
gap/contradictory-evidence
gap/needs-replication
gap/no-mechanism
gap/unsourced
gap/needs-canonical-id
Aug 31, 2026
macaca-fascicularis
gap/no-fulltext-access
gap/needs-canonical-id
gap/needs-replication
gap/unsourced
gap/no-mechanism
Aug 31, 2026
mus-musculus
gap/needs-replication
gap/needs-human-replication
gap/unsourced
Aug 31, 2026
malassezia
gap/needs-replication
gap/no-mechanism
gap/dose-response-unclear
gap/contradictory-evidence
gap/needs-human-replication
gap/long-term-unknown
gap/no-fulltext-access
Aug 31, 2026
oral-microbiome-aging-shifts
gap/needs-replication
gap/dose-response-unclear
gap/no-fulltext-access
gap/needs-human-replication
gap/long-term-unknown
gap/no-mechanism
Aug 31, 2026
porphyromonas-gingivalis
gap/needs-human-replication
gap/needs-replication
gap/contradictory-evidence
gap/no-mechanism
gap/long-term-unknown
gap/dose-response-unclear
gap/no-fulltext-access
Aug 31, 2026
skin-microbiome-aging-shifts
gap/contradictory-evidence
gap/no-mechanism
gap/needs-replication
gap/needs-human-replication
gap/unsourced
gap/no-fulltext-access
Aug 31, 2026
staphylococcus-epidermidis
gap/needs-replication
gap/needs-human-replication
gap/long-term-unknown
gap/dose-response-unclear
Aug 31, 2026
balaena-mysticetus
gap/unsourced
gap/needs-replication
gap/needs-human-replication
gap/no-mechanism
gap/dose-response-unclear
gap/long-term-unknown
Aug 31, 2026
caenorhabditis-elegans
gap/no-fulltext-access
gap/needs-human-replication
gap/contradictory-evidence
gap/needs-replication
gap/no-mechanism
gap/unsourced
stub
Aug 31, 2026
akkermansia-muciniphila
gap/no-fulltext-access
gap/needs-human-replication
gap/needs-replication
gap/contradictory-evidence
gap/unsourced
gap/long-term-unknown
gap/no-mechanism
gap/dose-response-unclear
Aug 31, 2026
bifidobacterium
gap/needs-replication
gap/no-fulltext-access
gap/contradictory-evidence
gap/no-mechanism
gap/needs-human-replication
gap/long-term-unknown
gap/dose-response-unclear
gap/unsourced
Aug 31, 2026
cutibacterium-acnes
gap/needs-replication
gap/no-fulltext-access
gap/needs-human-replication
gap/unsourced
gap/no-mechanism
gap/long-term-unknown
Aug 31, 2026
ewingella-americana
gap/needs-replication
gap/needs-strain-genome
gap/unsourced
gap/needs-human-replication
gap/dose-response-unclear
gap/long-term-unknown
gap/no-mechanism
gap/no-fulltext-access
Aug 31, 2026
firmicutes-bacteroidetes-ratio
gap/dose-response-unclear
gap/needs-human-replication
gap/contradictory-evidence
gap/needs-replication
gap/no-mechanism
Aug 31, 2026
gut-microbiome-aging-shifts
gap/contradictory-evidence
gap/needs-replication
gap/needs-human-replication
gap/no-mechanism
Aug 31, 2026
lactobacillus
gap/needs-human-replication
gap/needs-replication
gap/contradictory-evidence
gap/unsourced
gap/no-mechanism
gap/long-term-unknown
gap/dose-response-unclear
gap/no-fulltext-access
Aug 31, 2026
cas12a2-trans-cleavage
gap/no-fulltext-access
gap/long-term-unknown
gap/no-mechanism
Aug 31, 2026
dti-alps
gap/contradictory-evidence
gap/needs-replication
Aug 31, 2026
in-vivo-base-editing
gap/long-term-unknown
gap/needs-replication
gap/no-fulltext-access
Aug 31, 2026
mendelian-randomization
gap/instrument-validity-uncertain
Aug 31, 2026
p16-immunodetection
gap/needs-replication
gap/no-fulltext-access
Aug 31, 2026
single-cell-rna-seq
gap/no-fulltext-access
gap/needs-replication
Aug 31, 2026
wgcna
gap/no-fulltext-access
Aug 31, 2026
R8
gap/no-fulltext-access
gap/unsourced
gap/needs-replication
gap/needs-canonical-id
gap/contradictory-evidence
gap/long-term-unknown
gap/no-mechanism
gap/needs-human-replication
Aug 31, 2026
R9
gap/no-fulltext-access
gap/unsourced
gap/no-mechanism
gap/contradictory-evidence
gap/needs-human-replication
Aug 31, 2026
recency
gap/needs-replication
gap/contradictory-evidence
stub
Aug 31, 2026
R6
gap/no-fulltext-access
gap/unsourced
gap/contradictory-evidence
gap/needs-replication
gap/no-mechanism
gap/needs-human-replication
gap/needs-canonical-id
gap/long-term-unknown
gap/dose-response-unclear
gap/pending
Aug 31, 2026
R7
gap/needs-canonical-id
gap/no-fulltext-access
gap/unsourced
gap/needs-replication
gap/needs-human-replication
gap/long-term-unknown
gap/no-mechanism
gap/dose-response-unclear
gap/contradictory-evidence
Aug 31, 2026
R44
gap/needs-human-replication
gap/no-fulltext-access
gap/needs-replication
gap/needs-fulltext
Aug 31, 2026
R45
gap
gap/needs-tagging
Aug 31, 2026
R5
gap/unsourced
gap/no-mechanism
gap/no-fulltext-access
gap/needs-replication
gap/needs-canonical-id
gap
gap/needs-primary-source
gap/contradictory-evidence
gap/needs-human-replication
gap/long-term-unknown
gap/dose-response-unclear
Aug 31, 2026
R4
gap/no-fulltext-access
gap/needs-human-replication
gap/contradictory-evidence
gap/dose-response-unclear
gap/no-mechanism
gap/needs-replication
gap/unsourced
Aug 31, 2026
R40
gap/no-mechanism
gap/no-fulltext-access
Aug 31, 2026
R41
3
gap/needs-full-text-verification
gap/needs-canonical-id
Aug 31, 2026
R42
gap/unsourced
gap/no-fulltext-access
gap/contradictory-evidence
gap/stub
gap/no-mechanism
Aug 31, 2026
R36
gap/unsourced
gap/no-fulltext-access
gap/contradictory-evidence
gap/needs-replication
gap/needs-human-replication
gap/cutoffs-not-from-primary-source
Aug 31, 2026
R37
gap/no-fulltext-access
gap
gap/needs-verification
gap/needs-replication
gap/unsourced
gap/contradictory-evidence
Aug 31, 2026
R34
gap/unsourced
gap/no-fulltext-access
gap/needs-canonical-id
gap/contradictory-evidence
gap/doi-unconfirmed
gap/needs-pdf-verification
gap/needs-replication
Aug 31, 2026
R35
gap/needs-citation
gap/needs-doi-confirmation
gap/no-fulltext-access
gap/unverified-source
gap/unsourced
gap/needs-replication
gap/stub
gap/dose-response-unclear
Aug 31, 2026
R31
gap/no-fulltext-access
gap/needs-primary-source
gap/needs-replication
gap/unsourced
gap/needs-canonical-id
Aug 31, 2026
R32
gap/no-fulltext-access
gap/unsourced
gap/needs-replication
gap/no-mechanism
gap/needs-canonical-id
Aug 31, 2026
R33
gap/no-fulltext-access
gap/needs-canonical-id
gap/needs-replication
gap/unsourced
gap/no-opentargets-entry
Aug 31, 2026
R25
gap/no-fulltext-access
gap/not-queried
gap/unsourced
gap/no-uniprot-noncoding-rna
gap/needs-citation
unsourced
gap/needs-replication
gap/needs-mechanistic-detail
gap/no-mechanism
Aug 31, 2026
R28
gap/no-fulltext-access
gap/unsourced
Aug 31, 2026
R29
gap/no-fulltext-access
gap/unsourced
gap/needs-replication
gap/needs-human-replication
Aug 31, 2026
R3
gap/no-fulltext-access
gap/unsourced
gap/contradictory-evidence
gap/needs-replication
Aug 31, 2026
R30
gap/needs-replication
Aug 31, 2026
R23
gap/no-fulltext-access
gap/unsourced
Aug 31, 2026
R24
gap/no-fulltext-access
gap/needs-replication
Aug 31, 2026
R12
gap/unsourced
gap/no-fulltext-access
Aug 31, 2026
R17
gap/unsourced
gap/unverified-archive-failure
gap/no-fulltext-access
gap/needs-canonical-id
gap/needs-replication
Aug 31, 2026
R2
gap/no-fulltext-access
gap/unsourced
Aug 31, 2026
R20
gap/no-fulltext-access
gap/needs-replication
gap/unsourced
gap/needs-canonical-id
stub
Aug 31, 2026
R10
gap/no-fulltext-access
gap/unsourced
gap/needs-replication
gap/needs-human-replication
gap/contradictory-evidence
gap/no-mechanism
gap/long-term-unknown
gap/dose-response-unclear
gap/needs-canonical-id
gap/needs-verification
gap
stub
Aug 31, 2026
R11
gap/no-fulltext-access
gap/contradictory-evidence
gap/needs-human-replication
gap/needs-replication
gap/long-term-unknown
gap/dose-response-unclear
Aug 31, 2026
R1
gap/unsourced
gap/no-fulltext-access
gap/needs-replication
Aug 31, 2026
2026-06-14
stub
gap/no-fulltext-access
Aug 31, 2026
2026-06-15
gap-tagged
gap/no-fulltext-access
gap/needs-replication
gap/contradictory-evidence
currentage
Aug 31, 2026
2026-06-24
gap/needs-verification
Aug 31, 2026
2026-06-25
gap/contradictory-evidence
gap/no-fulltext-access
Aug 31, 2026
2026-06-26
gap/needs-human-replication
gap/needs-replication
Aug 31, 2026
2026-06-27
gap/contradictory-evidence
gap/no-fulltext-access
Aug 31, 2026
2026-06-28
gap/contradictory-evidence
Aug 31, 2026
2026-06-30
gap/no-fulltext-access
gap/needs-full-paper-publication
gap/needs-human-replication
gap/contradictory-evidence
Aug 31, 2026
2026-07-11
gap/needs-replication
gap/contradictory-evidence
gap/needs-human-replication
Aug 31, 2026
2026-06-04
gap/no-fulltext-access
gap/contradictory-evidence
gap/not-yet-done
gap/unsourced
gap/needs-replication
gap
gap/needs-canonical-id
3
Aug 31, 2026
2026-06-07
gap/needs-human-replication
stub
Aug 31, 2026
2026-06-09
gap/needs-canonical-id
gap/no-mechanism
gap/needs-fulltext
gap/no-fulltext-access
Aug 31, 2026
2026-06-11
gap
gaps
Aug 31, 2026
2026-06-12
gaps
gap/no-fulltext-access
gap/contradictory-evidence
gap/loop-stability
gap/needs-state-node-migration
gap/intercept-not-reported
Aug 31, 2026
2026-06-13
gap/no-fulltext-access
gap/future-seeding
gap/abstract-unavailable
Aug 31, 2026
2026-05-29
gap/needs-human-replication
gap
gap/no-fulltext-access
gap/needs-extended-data-verification
gap/contradictory-evidence
gap/no-mechanism
Aug 31, 2026
2026-05-31
gap/dose-response-unclear
gap/needs-replication
gap/no-fulltext-access
gap
gap/contradictory-evidence
gap/unsourced
gap/needs-fulltext-verification
gap/needs-pdf
gap/needs-healthy-population-replication
Aug 31, 2026
2026-06-02
gap/no-fulltext-access
gap/unsourced
gap/contradictory-evidence
Aug 31, 2026
2026-06-03
gap/dose-response-unclear
gap/needs-human-replication
gap/unsourced
gap
gap/contradictory-evidence
Aug 31, 2026
2026-05-21
gap/needs-supp-verification
gap/needs-full-extraction
gap/needs-replication
gap/needs-gtex-extraction
gap/unsourced
Aug 31, 2026
2026-05-23
gap/no-fulltext-access
gap/no-mechanism
gap
gap/needs-page
gap/unsourced
gap/contradictory-evidence
gap/needs-replication
Aug 31, 2026
2026-05-25
gap/needs-replication
gap/no-mechanism
gap/contradictory-evidence
gap
gap/needs-verification
gap/no-fulltext-access
Aug 31, 2026
2026-05-26
gap
gap/unsourced
stub
gap/contradictory-evidence
Aug 31, 2026
2026-05-27
gap/needs-canonical-id
gap/needs-verification
gap
gap/no-fulltext-access
Aug 31, 2026
ipsc-derived-cell-therapy
gap/needs-replication
gap/long-term-unknown
gap/no-mechanism
gap/unsourced
gap/needs-human-replication
Aug 31, 2026
mesenchymal-stem-cell-therapy
gap/no-mechanism
gap/needs-replication
gap/dose-response-unclear
gap/no-fulltext-access
gap/contradictory-evidence
gap/long-term-unknown
gap/unsourced
Aug 31, 2026
log
gap/dose-response-unclear
gap/unsourced
gap/no-fulltext-access
gap/needs-canonical-id
gap/needs-pdf-verification
Aug 31, 2026
2026-05-20
gap/no-mechanism
gap/no-fulltext-access
gap/needs-replication
gap/needs-human-replication
gap/dose-response-unclear
gap/not-in-genage
gap/unsourced
gap/needs-canonical-id
gap/needs-peer-review
Aug 31, 2026
testosterone-replacement-therapy
gap/needs-replication
gap/unsourced
gap/needs-human-replication
gap/long-term-unknown
gap/dose-response-unclear
gap/contradictory-evidence
gap/surrogate-endpoint
Aug 31, 2026
topical-estrogens
gap/needs-replication
gap/no-mechanism
gap/dose-response-unclear
gap/long-term-unknown
gap/needs-human-replication
gap/unsourced
Aug 31, 2026
microneedling
gap/needs-fulltext
gap/needs-replication
gap/no-mechanism
gap/long-term-unknown
gap/contradictory-evidence
gap/dose-response-unclear
Aug 31, 2026
vascular-laser
gap/long-term-unknown
gap/needs-replication
gap/no-mechanism
gap/needs-human-replication
gap/no-fulltext-access
Aug 31, 2026
venous-valve-reconstruction
gap/needs-replication
gap/no-mechanism
gap/contradictory-evidence
gap/no-fulltext-access
Aug 31, 2026
hematopoietic-stem-cell-transplantation
gap/needs-human-replication
gap/needs-replication
gap/long-term-unknown
gap/no-mechanism
Aug 31, 2026
in-vivo-partial-reprogramming-therapy
gap/needs-human-replication
gap/needs-replication
gap/contradictory-evidence
gap/unsourced
gap/long-term-unknown
gap/dose-response-unclear
Aug 31, 2026
selective-estrogen-receptor-modulators
gap/needs-human-replication
gap/needs-replication
gap/dose-response-unclear
gap/long-term-unknown
Aug 31, 2026
senolytics
gap/no-fulltext-access
gap/needs-human-replication
gap/preprint-not-peer-reviewed
gap/needs-replication
gap/long-term-unknown
gap/dose-response-unclear
gap/no-mechanism
gap/needs-full-paper-publication
Aug 31, 2026
senomorphics
gap/needs-human-replication
gap/needs-replication
gap/unsourced
gap/dose-response-unclear
gap/no-fulltext-access
gap/long-term-unknown
gap/contradictory-evidence
gap/no-mechanism
Aug 31, 2026
sirtuin-activators
gap/contradictory-evidence
gap/needs-human-replication
gap/unsourced
gap/long-term-unknown
gap/needs-replication
gap/dose-response-unclear
Aug 31, 2026
statins
gap/needs-canonical-id
gap/needs-replication
gap/contradictory-evidence
gap/stub
Aug 31, 2026
telomerase-activators
gap/no-mechanism
gap/needs-replication
gap/long-term-unknown
gap/contradictory-evidence
gap/needs-human-replication
gap/unsourced
gap/dose-response-unclear
Aug 31, 2026
telomeric-antisense-oligonucleotides
gap/long-term-unknown
gap/needs-human-replication
gap/needs-replication
gap/dose-response-unclear
Aug 31, 2026
mtor-inhibitors
gap/no-fulltext-access
gap/needs-human-replication
gap/needs-replication
gap/contradictory-evidence
gap/long-term-unknown
gap/no-mechanism
gap/dose-response-unclear
Aug 31, 2026
nad-precursors
gap/contradictory-evidence
gap/needs-replication
gap/needs-human-replication
gap/dose-response-unclear
gap/no-mechanism
gap/long-term-unknown
Aug 31, 2026
nanoparticle-immunoadjuvants
gap/needs-human-replication
gap/needs-aged-host-validation
gap/long-term-unknown
gap/needs-mechanism
gap/dose-response-unclear
gap/needs-replication
gap/needs-full-extraction
gap/no-fulltext-access
Aug 31, 2026
parp-inhibitors
gap/needs-human-replication
gap/no-mechanism
gap/contradictory-evidence
gap/needs-replication
gap/long-term-unknown
gap/no-fulltext-access
Aug 31, 2026
peptide-therapeutics
gap/needs-canonical-id
gap/no-fulltext-access
Aug 31, 2026
ppara-agonists
gap/needs-human-replication
gap/contradictory-evidence
gap/needs-replication
gap/unsourced
gap/no-disclosure
gap/no-mechanism
gap/no-fulltext-access
non-peer-reviewed-analysis
Aug 31, 2026
retinoids
gap/needs-replication
gap/no-mechanism
gap/long-term-unknown
gap/needs-human-replication
gap/dose-response-unclear
gap/no-fulltext-access
Aug 31, 2026
dna-pkcs-inhibitors
gap/unsourced
gap/needs-human-replication
gap/no-mechanism
gap/needs-replication
gap/dose-response-unclear
gap/no-fulltext-access
Aug 31, 2026
exosome-skin-therapy
gap/needs-mechanism
gap/needs-human-replication
gap/needs-replication
gap/no-mechanism
gap/long-term-unknown
gap/needs-fulltext
Aug 31, 2026
glp1-agonists
gap/no-mechanism
gap/unsourced
gap/needs-human-replication
gap/needs-replication
gap/needs-pdf-verification
gap/contradictory-evidence
gap/dose-response-unclear
gap/long-term-unknown
Aug 31, 2026
hdac-inhibitors
gap/contradictory-evidence
gap/needs-human-replication
gap/needs-replication
gap/long-term-unknown
gap/dose-response-unclear
gap/no-fulltext-access
Aug 31, 2026
hormone-replacement-therapy
gap/contradictory-evidence
gap/needs-replication
gap/needs-human-replication
gap/long-term-unknown
Aug 31, 2026
il-11-gene-silencing
gap/needs-replication
gap/needs-human-replication
gap/dose-response-unclear
gap/long-term-unknown
Aug 31, 2026
injectable-skin-boosters
gap/needs-replication
gap/no-mechanism
gap/needs-human-replication
gap/long-term-unknown
Aug 31, 2026
ampk-activators
gap/contradictory-evidence
gap/needs-replication
gap/needs-human-replication
gap/no-mechanism
gap/long-term-unknown
Aug 31, 2026
anti-il-11-antibodies
gap/needs-replication
gap/needs-human-replication
gap/long-term-unknown
gap/dose-response-unclear
Aug 31, 2026
aromatase-inhibitors
gap/no-fulltext-access
gap/needs-citation-for-oophorectomy-bone-loss-comparison
gap/contradictory-evidence
gap/needs-replication
gap/long-term-unknown
Aug 31, 2026
bacterial-cancer-therapy
gap/needs-primary-citation
gap/aging-context-untested
gap/no-mechanism
gap/needs-replication
gap/needs-human-replication
gap/dose-response-unclear
stub-needed
Aug 31, 2026
biostimulatory-fillers
gap/needs-replication
gap/needs-canonical-id
gap/needs-human-replication
stub
gap/long-term-unknown
gap/contradictory-evidence
gap/no-mechanism
Aug 31, 2026
cgas-modulators
gap/no-fulltext-access
gap/needs-replication
gap/no-mechanism
gap/unsourced
gap/needs-human-replication
gap/long-term-unknown
gap/dose-response-unclear
Aug 31, 2026
chemical-peels
gap/stub
gap/needs-replication
gap/needs-human-replication
gap/long-term-unknown
gap/no-mechanism
gap/no-fulltext-access
Aug 31, 2026
dermatologic-resurfacing
gap/needs-replication
gap/unsourced
gap/contradictory-evidence
gap/dose-response-unclear
gap/long-term-unknown
gap/needs-fulltext
Aug 31, 2026
protein-intake
gap/needs-replication
gap/contradictory-evidence
gap/needs-human-replication
Aug 31, 2026
sleep
gap/contradictory-evidence
gap/needs-human-replication
gap/needs-replication
gap/dose-response-unclear
gap/unsourced
Aug 31, 2026
time-restricted-eating
gap/no-fulltext-access
gap/needs-human-replication
gap/needs-replication
gap/contradictory-evidence
gap/long-term-unknown
Aug 31, 2026
uv-protection
gap/needs-replication
gap/no-independent-replication
gap/long-term-unknown
gap/dose-response-unclear
gap/no-fulltext-access
Aug 31, 2026
age-crosslink-breakers
gap/contradictory-evidence
gap/needs-replication
gap/needs-human-replication
gap/needs-primary-source-verification
gap/no-mechanism
gap/long-term-unknown
gap/no-fulltext-access
Aug 31, 2026
allele-selective-oligonucleotides
gap/needs-replication
gap/needs-human-replication
gap/no-mechanism
gap/dose-response-unclear
gap/long-term-unknown
Aug 31, 2026
exercise
gap/needs-human-replication
gap/needs-replication
gap/dose-response-unclear
gap/no-mechanism
gap/no-fulltext-access
Aug 31, 2026
heat-exposure
gap/needs-replication
gap/needs-human-replication
gap/no-mechanism
unsourced
gap/contradictory-evidence
gap/dose-response-unclear
gap/long-term-unknown
gap/no-fulltext-access
Aug 31, 2026
intermittent-fasting
gap/dose-response-unclear
gap/needs-human-replication
gap/contradictory-evidence
gap/needs-replication
gap/long-term-unknown
gap/no-fulltext-access
gap/unsourced
Aug 31, 2026
ketogenic-diet
gap/needs-human-replication
gap/needs-replication
gap/no-mechanism
gap/contradictory-evidence
gap/long-term-unknown
gap/no-fulltext-access
Aug 31, 2026
methionine-restriction
gap/needs-replication
gap/no-mechanism
gap/contradictory-evidence
gap/needs-human-replication
gap/long-term-unknown
gap/no-fulltext-access
Aug 31, 2026
prolonged-fasting
gap/no-mechanism
gap/needs-human-replication
gap/contradictory-evidence
gap/needs-replication
gap/long-term-unknown
gap/dose-response-unclear
Aug 31, 2026
aav-follistatin
gap/needs-replication
gap/long-term-unknown
gap/no-mechanism
gap/needs-human-replication
gap/contradictory-evidence
gap/dose-response-unclear
Aug 31, 2026
aav-klotho
gap/needs-replication
gap/needs-human-replication
gap/no-fulltext-access
gap/dose-response-unclear
gap/long-term-unknown
gap/no-mechanism
Aug 31, 2026
aav-osk
gap/needs-replication
gap/needs-human-replication
gap/long-term-unknown
gap/unsourced
gap/dose-response-unclear
Aug 31, 2026
aav-tert
gap/needs-replication
gap/needs-human-replication
gap/unsourced
gap/long-term-unknown
gap/no-mechanism
gap/dose-response-unclear
Aug 31, 2026
crispr-base-editing-pcsk9
gap/needs-replication
gap/no-mechanism
gap/long-term-unknown
gap/needs-human-replication
gap/no-fulltext-access
Aug 31, 2026
transcript-activated-cell-ablation
gap/no-mechanism
gap/needs-replication
gap/long-term-unknown
Aug 31, 2026
caloric-restriction
gap/unsourced
gap/no-fulltext-access
gap/needs-human-replication
gap/dose-response-unclear
gap/needs-replication
Aug 31, 2026
mediterranean-diet
gap/needs-replication
gap/dose-response-unclear
gap/needs-human-replication
gap/no-mechanism
gap/contradictory-evidence
gap/post-hoc-subgroup
gap/mrna-only-readout
Aug 31, 2026
multivitamins
gap/contradictory-evidence
Aug 31, 2026
phosphate-additive-reduction
gap/dose-response-unclear
gap/needs-replication
gap/needs-human-replication
gap/unsourced
gap/no-mechanism
Aug 31, 2026
postbiotics
gap/needs-human-replication
gap/needs-replication
gap/contradictory-evidence
gap/no-mechanism
gap/long-term-unknown
Aug 31, 2026
prebiotics
gap/dose-response-unclear
gap/no-mechanism
gap/needs-human-replication
gap/needs-replication
gap/no-fulltext-access
gap/contradictory-evidence
stub
gap/long-term-unknown
Aug 31, 2026
probiotics
gap/needs-human-replication
gap/no-approved-hydrogenotrophic-probiotic
gap/needs-extraction
gap/needs-invitro-gas-data
gap/no-direct-evidence
gap/contradictory-evidence
gap/needs-updated-survey
gap/needs-verification
Aug 31, 2026
resistant-starch
gap/dose-response-unclear
gap/long-term-unknown
gap/no-direct-evidence
Aug 31, 2026
sodium-restriction
gap/needs-replication
gap/contradictory-evidence
gap/no-mechanism
gap/needs-human-replication
Aug 31, 2026
somatic-mutation-theory-of-aging
gap/unsourced
gap/needs-replication
gap/needs-human-replication
gap/contradictory-evidence
gap/no-fulltext-access
Aug 31, 2026
translation-failure-of-aging-interventions
gap/unsourced
gap/no-mechanism
gap/synthesis-needed
gap/needs-replication
gap/no-fulltext-access
Aug 31, 2026
heterochronic-parabiosis
gap/contradictory-evidence
gap/needs-human-replication
gap/needs-replication
gap/long-term-unknown
gap/no-fulltext-access
Aug 31, 2026
plasma-exchange
gap/needs-replication
gap/contradictory-evidence
gap/needs-peer-review
gap/unsourced
gap/needs-human-replication
gap/long-term-unknown
gap/no-mechanism
gap/dose-response-unclear
gap/no-fulltext-access
Aug 31, 2026
fermented-foods
gap/contradictory-evidence
gap/dose-response-unclear
gap/no-mechanism
gap/needs-replication
gap/long-term-unknown
Aug 31, 2026
fmt
gap/unsourced
gap/needs-human-replication
gap/needs-replication
gap/no-fulltext-access
gap/no-mechanism
gap/long-term-unknown
gap/dose-response-unclear
Aug 31, 2026
free-radical-theory-of-aging
gap/unsourced
gap/needs-replication
gap/contradictory-evidence
gap/no-mechanism
gap/no-fulltext-access
Aug 31, 2026
hyperfunction-theory
gap
gap/no-fulltext-access
gap/synthesis-needed
Aug 31, 2026
information-theory-of-aging
gap/needs-replication
gap/needs-human-replication
gap/contradictory-evidence
gap/long-term-unknown
gap/unsourced
Aug 31, 2026
longevity-escape-velocity
gap/no-mechanism
gap/needs-human-replication
gap/contradictory-evidence
gap/unsourced
gap/no-fulltext-access
Aug 31, 2026
mitohormesis
gap/needs-human-replication
gap/needs-replication
gap/unsourced
gap/contradictory-evidence
gap/dose-response-unclear
Aug 31, 2026
mothers-curse
gap/needs-human-replication
gap/contradictory-evidence
gap/needs-replication
gap/no-mechanism
gap/unsourced
gap/no-fulltext-access
Aug 31, 2026
negligible-senescence
gap/needs-replication
gap/no-fulltext-access
gap/unsourced
gap/contradictory-evidence
gap/no-mechanism
Aug 31, 2026
androgen-deprivation-longevity-hypothesis
gap/no-fulltext-access
gap/contradictory-evidence
gap/needs-human-replication
gap/needs-replication
gap/no-mechanism
gap/not-yet-done
gap/stub
Aug 31, 2026
antagonistic-pleiotropy
gap/unsourced
gap/needs-replication
gap/no-fulltext-access
gap/no-mechanism
gap/needs-citation-verification
Aug 31, 2026
d3-k2-calcium-partitioning
gap/needs-human-replication
gap/unsourced
gap/needs-replication
stub
gap/no-fulltext-access
Aug 31, 2026
disposable-soma-theory
gap/unsourced
gap/contradictory-evidence
gap/needs-replication
gap/stub
gap/no-fulltext-access
Aug 31, 2026
dna-damage-theory-of-aging
gap/unsourced
gap/needs-replication
gap/no-fulltext-access
gap/needs-human-replication
gap/contradictory-evidence
Aug 31, 2026
female-longevity-advantage
gap/needs-human-replication
gap/needs-replication
gap/no-mechanism
gap/contradictory-evidence
gap/unsourced
gap/stub
gap/no-fulltext-access
Aug 31, 2026
dysbiosis
gap/contradictory-evidence
gap/unsourced
gap/no-mechanism
gap/needs-replication
gap/needs-human-replication
stub
gap/no-fulltext-access
Aug 31, 2026
epigenetic-alterations
gap/unsourced
gap/contradictory-evidence
gap/needs-replication
gap/needs-human-replication
gap/long-term-unknown
Aug 31, 2026
genomic-instability
gap/unsourced
gap/needs-human-replication
gap/no-fulltext-access
gap/needs-replication
gap/long-term-unknown
gap/no-mechanism
gap/contradictory-evidence
Aug 31, 2026
loss-of-proteostasis
gap/needs-human-replication
gap/needs-replication
gap/long-term-unknown
gap/unsourced
gap/dose-response-unclear
gap/contradictory-evidence
gap/no-fulltext-access
Aug 31, 2026
mitochondrial-dysfunction
gap/no-mechanism
gap/unsourced
gap/contradictory-evidence
gap/long-term-unknown
gap/needs-human-replication
gap/needs-replication
gap/dose-response-unclear
Aug 31, 2026
stem-cell-exhaustion
gap/no-fulltext-access
gap/unsourced
gap/contradictory-evidence
gap/needs-replication
gap/needs-human-replication
gap/long-term-unknown
gap/dose-response-unclear
Aug 31, 2026
telomere-attrition
gap/dose-response-unclear
gap/unsourced
gap/no-mechanism
gap/needs-replication
gap/long-term-unknown
gap/needs-human-replication
gap/no-fulltext-access
Aug 31, 2026
cellular-senescence
gap/needs-replication
gap/no-mechanism
gap/preprint-not-peer-reviewed
gap/no-fulltext-access
gap/needs-human-replication
gap/unsourced
gap/long-term-unknown
gap/contradictory-evidence
Aug 31, 2026
chronic-inflammation
gap/no-mechanism
gap/unsourced
gap/no-fulltext-access
gap/needs-human-replication
gap/contradictory-evidence
gap/needs-replication
gap/needs-peer-review
gap/long-term-unknown
gap/no-fulltext-access-yet
Aug 31, 2026
deregulated-nutrient-sensing
gap/no-fulltext-access
gap/needs-human-replication
gap/unsourced
gap/no-mechanism
Aug 31, 2026
disabled-adaptive-immunity
gap/needs-human-replication
gap/no-fulltext-access
gap/needs-replication
gap/no-mechanism
gap/long-term-unknown
gap/needs-fulltext-verification
Aug 31, 2026
disabled-macroautophagy
gap/needs-human-replication
gap/no-mechanism
gap/unsourced
gap/dose-response-unclear
Aug 31, 2026
intervention-classes
gap/class-normalisation-needed
gap/stub
Aug 31, 2026
interventions-by-hallmark
gap/needs-seeding
gap/needs-tagging
Aug 31, 2026
interventions-testing-program
gap/needs-citation-pass
gap/needs-replication
gap/needs-full-text
gap/needs-study-pages
gap/contradictory-evidence
gap/no-fulltext-access
Aug 31, 2026
sens-damage-categories
gap/needs-primary-source-verification
gap/contradictory-evidence
Aug 31, 2026
altered-intercellular-communication
gap/unsourced
gap/contradictory-evidence
gap/needs-replication
gap/needs-human-replication
gap/no-mechanism
gap/long-term-unknown
gap/no-fulltext-access
Aug 31, 2026
intervention-by-target-immunogenicity
gap/long-term-unknown
gap/stub
Aug 31, 2026
causal-graph-parameters
gap
Aug 31, 2026
engineered-negligible-senescence
gap/stub
Aug 31, 2026
hallmarks-of-aging
gap/contradictory-evidence
gap/no-mechanism
Aug 31, 2026
heart-rate-zones
gap/needs-aging-specific-data
gap/contradictory-evidence
gap/needs-replication
Aug 31, 2026
cancer-aging-tradeoffs
gap/needs-human-replication
gap/no-mechanism
gap/long-term-unknown
Aug 31, 2026
air-pollution
gap/no-mechanism
gap/needs-human-replication
gap/dose-response-unclear
gap/needs-replication
gap/contradictory-evidence
Aug 31, 2026
alcohol
gap/no-fulltext-access
gap/contradictory-evidence
gap/needs-replication
gap/long-term-unknown
gap/dose-response-unclear
gap/needs-human-replication
Aug 31, 2026
dietary-fat-quality
gap/contradictory-evidence
gap/needs-replication
gap/needs-human-replication
gap/dose-response-unclear
gap/no-fulltext-access
Aug 31, 2026
smoking
gap/dose-response-unclear
gap/needs-replication
gap/long-term-unknown
gap/no-mechanism
stub
Aug 31, 2026
apoptosenes
gap/needs-human-replication
gap/unsourced
gap/needs-replication
gap/dose-response-unclear
gap/long-term-unknown
Aug 31, 2026
biological-age-measurement
gap/needs-peer-review
gap/no-fulltext-access
gap/needs-replication
gap/contradictory-evidence
Aug 31, 2026
osteocytes
gap/contradictory-evidence
gap/needs-replication
gap/no-mechanism
gap/needs-sc-aging-data
gap/no-fulltext-access
gap/needs-human-replication
Aug 31, 2026
ovarian-stromal-fibroblasts
gap/no-singlecell-data
gap/needs-human-replication
gap/needs-replication
gap/long-term-unknown
Aug 31, 2026
satellite-cells
gap/contradictory-evidence
gap/needs-replication
gap/needs-human-replication
gap/long-term-unknown
gap/no-fulltext-access
Aug 31, 2026
schwann-cells
gap/needs-human-replication
gap/unsourced
gap/needs-replication
gap/no-mechanism
gap/long-term-unknown
gap/no-fulltext-access
Aug 31, 2026
sertoli-cells
gap/needs-human-replication
gap/needs-replication
gap/no-mechanism
gap/long-term-unknown
gap/no-fulltext-access
Aug 31, 2026
spermatogonial-stem-cells
gap/needs-replication
gap/long-term-unknown
gap/no-mechanism
gap/no-fulltext-access
gap/needs-human-replication
Aug 31, 2026
theca-cells
gap/no-mechanism
gap/needs-replication
gap/dose-response-unclear
gap/needs-human-replication
gap/no-fulltext-access
Aug 31, 2026
vsmc
gap/needs-replication
gap/needs-human-replication
Aug 31, 2026
myofibers
gap/needs-replication
gap/unsourced
gap/needs-human-replication
gap/no-fulltext-access
Aug 31, 2026
neural-stem-cells
gap/unsourced
gap/contradictory-evidence
gap/needs-human-replication
gap/needs-replication
gap/long-term-unknown
Aug 31, 2026
neurons
gap/contradictory-evidence
gap/needs-human-replication
gap/no-fulltext-access
gap/needs-replication
gap/no-mechanism
gap/long-term-unknown
Aug 31, 2026
oligodendrocytes
gap/needs-replication
gap/no-mechanism
gap/needs-human-replication
Aug 31, 2026
oocytes
gap/no-fulltext-access
gap/needs-replication
gap/long-term-unknown
gap/contradictory-evidence
gap/needs-human-replication
gap/unsourced
gap/no-mechanism
Aug 31, 2026
osteoblasts
gap/no-fulltext-access
gap/dose-response-unclear
gap/needs-human-replication
gap/needs-replication
gap/needs-sc-aging-data
Aug 31, 2026
osteoclasts
gap/no-fulltext-access
gap/needs-human-replication
gap/long-term-unknown
gap/needs-sc-aging-data
gap/contradictory-evidence
gap/no-mechanism
gap/needs-replication
gap/needs-page
Aug 31, 2026
langerhans-cells
gap/needs-human-replication
gap/needs-replication
gap/no-mechanism
gap/contradictory-evidence
Aug 31, 2026
leydig-cells
gap/needs-human-replication
gap/contradictory-evidence
gap/long-term-unknown
gap/no-mechanism
gap/needs-replication
gap/no-fulltext-access
Aug 31, 2026
liver-sinusoidal-endothelial-cells
gap/needs-replication
gap/no-mechanism
gap/needs-human-replication
Aug 31, 2026
melanocyte-stem-cells
gap/needs-canonical-id
gap/no-fulltext-access
gap/needs-human-replication
gap/needs-replication
gap/unsourced
gap/no-mechanism
gap/long-term-unknown
Aug 31, 2026
melanocytes
gap/unsourced
gap/needs-replication
gap/no-fulltext-access
Aug 31, 2026
mesenchymal-stem-cells
gap/needs-human-replication
gap/contradictory-evidence
gap/needs-replication
gap/no-mechanism
gap/no-fulltext-access
Aug 31, 2026
microglia
gap/needs-human-replication
gap/unsourced
gap/no-mechanism
gap/no-fulltext-access
gap/needs-replication
gap/contradictory-evidence
gap/long-term-unknown
Aug 31, 2026
hematopoietic-stem-cells
gap/unsourced
gap/needs-human-replication
gap/needs-replication
gap/no-fulltext-access
gap/long-term-unknown
gap/no-mechanism
Aug 31, 2026
hepatic-progenitor-cells
gap/no-mechanism
gap/needs-human-replication
gap/contradictory-evidence
gap/unsourced
gap/no-fulltext-access
Aug 31, 2026
hepatic-stellate-cells
gap/needs-replication
gap/needs-human-replication
gap/unsourced
gap/long-term-unknown
gap/no-fulltext-access
Aug 31, 2026
hepatocytes
gap/needs-replication
gap/needs-human-replication
gap/long-term-unknown
gap/unsourced
stub
Aug 31, 2026
induced-pluripotent-stem-cells
gap/unsourced
gap/needs-replication
gap/no-fulltext-access
Aug 31, 2026
keratinocytes
gap/unsourced
gap/contradictory-evidence
gap/needs-human-replication
gap/needs-replication
gap/no-fulltext-access
Aug 31, 2026
kupffer-cells
gap/needs-human-replication
gap/needs-replication
gap/unsourced
gap/no-mechanism
gap/contradictory-evidence
gap/no-fulltext-access
Aug 31, 2026
cardiac-fibroblasts
gap/no-fulltext-access
gap/needs-human-replication
gap/unsourced
gap/contradictory-evidence
gap/needs-replication
gap/long-term-unknown
gap/no-mechanism
Aug 31, 2026
cardiomyocytes
gap/needs-human-replication
gap/needs-replication
gap/unsourced
gap/contradictory-evidence
gap/long-term-unknown
gap/dose-response-unclear
gap/no-mechanism
gap/no-fulltext-access
Aug 31, 2026
cholangiocytes
gap/no-mechanism
gap/needs-human-replication
Aug 31, 2026
cumulus-cells
gap/needs-replication
gap/needs-human-replication
gap/no-mechanism
gap/long-term-unknown
Aug 31, 2026
dermal-fibroblasts
gap/contradictory-evidence
gap/needs-replication
gap/no-fulltext-access
gap/unsourced
gap/needs-human-replication
gap/no-mechanism
Aug 31, 2026
endothelial-cells
gap/needs-canonical-id
gap/needs-replication
gap/contradictory-evidence
Aug 31, 2026
fibroadipogenic-progenitors
gap/no-fulltext-access
gap/needs-canonical-id
gap/no-mechanism
gap/contradictory-evidence
gap/needs-human-replication
gap/needs-replication
gap/long-term-unknown
Aug 31, 2026
granulosa-cells
gap/needs-human-replication
gap/contradictory-evidence
gap/needs-replication
gap/no-mechanism
gap/long-term-unknown
Aug 31, 2026
skin-autofluorescence-age-reader
gap/needs-replication
gap/contradictory-evidence
gap/no-mechanism
gap/dose-response-unclear
gap/needs-human-replication
stub
Aug 31, 2026
skin-methylation-clocks
gap/no-fulltext-access
gap/needs-replication
gap/needs-human-replication
stub
Aug 31, 2026
symphony-age
gap/needs-replication
gap/no-mechanism
gap/no-fulltext-access
gap/unsourced
Aug 31, 2026
tapelift-clock-2026
gap/long-term-unknown
gap/no-mechanism
gap/needs-replication
Aug 31, 2026
telomere-length-leukocyte
gap/no-fulltext-access
gap/needs-replication
gap/contradictory-evidence
gap/no-mechanism
Aug 31, 2026
thymic-health-score
gap/no-fulltext-access
gap/needs-replication
gap/no-mechanism
gap/dose-response-unclear
Aug 31, 2026
transcriptomic-clock-tage
gap/needs-human-replication
gap/needs-replication
Aug 31, 2026
vo2max-biomarker
gap/dose-response-unclear
gap/needs-replication
gap/no-fulltext-access
gap/long-term-unknown
gap/unsourced
Aug 31, 2026
astrocytes
gap/no-mechanism
gap/no-fulltext-access
gap/contradictory-evidence
gap/needs-human-replication
gap/needs-replication
Aug 31, 2026
mskage-2025
gap/needs-replication
gap/contradictory-evidence
gap/no-mechanism
gap/needs-human-replication
gap/long-term-unknown
Aug 31, 2026
nad-blood-biomarker
gap/no-mechanism
Aug 31, 2026
nfl-biomarker
gap/needs-canonical-id
gap/needs-replication
gap/no-fulltext-access
gap/no-mechanism
gap/unsourced
gap/long-term-unknown
gap/not-tested-mr
stub
Aug 31, 2026
nlr-biomarker
gap/needs-replication
gap/no-fulltext-access
gap/unsourced
gap/long-term-unknown
Aug 31, 2026
omicmage
gap/needs-replication
gap/no-mechanism
gap/long-term-unknown
gap/unsourced
Aug 31, 2026
phenoage-2018
gap/needs-replication
gap/contradictory-evidence
gap/unsourced
Aug 31, 2026
qi-23k-epidermis-clock-2026
gap/needs-pdf-verification
gap/needs-replication
gap/no-mechanism
Aug 31, 2026
resting-heart-rate-biomarker
gap/contradictory-evidence
gap/unsourced
gap/no-mechanism
gap/dose-response-unclear
gap/needs-replication
Aug 31, 2026
heart-rate-variability-biomarker
gap/stub
gap/contradictory-evidence
gap/needs-human-replication
gap/no-mechanism
gap/dose-response-unclear
gap/needs-replication
Aug 31, 2026
homa-ir-biomarker
gap/no-fulltext-access
gap/cutoffs-not-from-primary-source
gap/unsourced
gap/contradictory-evidence
gap/no-mechanism
gap/needs-replication
Aug 31, 2026
horvath-clock-2013
gap/contradictory-evidence
gap/needs-replication
gap/unsourced
gap/no-mechanism
Aug 31, 2026
igf-1-biomarker
gap/needs-replication
gap/contradictory-evidence
gap/long-term-unknown
gap/unsourced
gap/dose-response-unclear
gap/no-fulltext-access
Aug 31, 2026
il-6-biomarker
gap/needs-replication
gap/dose-response-unclear
gap/needs-human-replication
gap/no-fulltext-access
Aug 31, 2026
lbp-biomarker
gap/needs-human-replication
gap/needs-replication
gap/no-mechanism
gap/unsourced
gap/dose-response-unclear
gap/no-fulltext-access
Aug 31, 2026
lehallier-proteomic-clock-2019
gap/needs-replication
gap/unsourced
gap/needs-human-replication
gap/long-term-unknown
gap/no-mechanism
gap/contradictory-evidence
Aug 31, 2026
menendez-vazquez-2025-mitrasolo-mitracluster
gap/needs-replication
gap/long-term-unknown
gap/needs-human-replication
Aug 31, 2026
dunedinpace-2022
gap/needs-replication
gap/contradictory-evidence
Aug 31, 2026
frailty-index
gap/unsourced
gap/needs-replication
gap/contradictory-evidence
gap/needs-human-replication
Aug 31, 2026
gdf-15-biomarker
gap/needs-replication
gap/dose-response-unclear
gap/no-mechanism
gap/contradictory-evidence
gap/unsourced
gap/no-fulltext-access
Aug 31, 2026
glycanage-2017
gap/needs-replication
gap/dose-response-unclear
gap/needs-peer-review
gap/unsourced
gap/needs-canonical-id
Aug 31, 2026
grimage-2019
gap/contradictory-evidence
gap/needs-replication
gap/unsourced
gap/no-mechanism
Aug 31, 2026
grip-strength-biomarker
gap/needs-replication
gap/no-fulltext-access
gap/no-mechanism
Aug 31, 2026
hannum-clock-2013
gap/unsourced
gap/contradictory-evidence
gap/no-mechanism
Aug 31, 2026
bormann-epidermis-clock-2016
gap/needs-canonical-id
gap/needs-replication
Aug 31, 2026
chip-clonal-hematopoiesis-biomarker
gap/dose-response-unclear
gap/needs-replication
gap/unsourced
gap/no-fulltext-access
gap/long-term-unknown
Aug 31, 2026
dnam-alcohol-consumption
gap/no-mechanism
gap/dose-response-unclear
gap/needs-replication
gap/long-term-unknown
gap/needs-human-replication
Aug 31, 2026
dnam-muscle-function-markers
gap/needs-replication
gap/contradictory-evidence
gap/needs-human-replication
gap/no-mechanism
gap/long-term-unknown
gap/no-fulltext-access